A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial
Abstract Healthy dietary patterns rich in legumes can improve metabolic health, although their additional benefits in conjunction with calorie restriction have not been well-established. We investigated effects of a calorie-restricted, legume-enriched, multicomponent intervention diet compared with...
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2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56084-6 |
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| author | Xiaorong Wu Alvin Surya Tjahyo Vera Sergeyevna Brok Volchanskaya Long Hui Wong Xianning Lai Yi Ning Yong Farhana Osman Shia Lyn Tay Priya Govindharajulu Shalini Ponnalagu Rachel Tso Hwee Sze Teo Kaijie Khoo Huan Fan Chew Chan Goh Clara Poh Lian Yap Melvin Khee-Shing Leow Christiani Jeyakumar Henry Sumanto Haldar Kevin Junliang Lim |
| author_facet | Xiaorong Wu Alvin Surya Tjahyo Vera Sergeyevna Brok Volchanskaya Long Hui Wong Xianning Lai Yi Ning Yong Farhana Osman Shia Lyn Tay Priya Govindharajulu Shalini Ponnalagu Rachel Tso Hwee Sze Teo Kaijie Khoo Huan Fan Chew Chan Goh Clara Poh Lian Yap Melvin Khee-Shing Leow Christiani Jeyakumar Henry Sumanto Haldar Kevin Junliang Lim |
| author_sort | Xiaorong Wu |
| collection | DOAJ |
| description | Abstract Healthy dietary patterns rich in legumes can improve metabolic health, although their additional benefits in conjunction with calorie restriction have not been well-established. We investigated effects of a calorie-restricted, legume-enriched, multicomponent intervention diet compared with a calorie-restricted control diet in 127 Chinese prediabetes participants, living in Singapore. The study was a 16-week, single-blind, parallel-design, randomized controlled trial (n = 63 intervention group (IG), n = 64 control group (CG); mean ± SD age 62.2 ± 6.3 years, BMI 23.8 ± 2.6 kg/m2). Primary outcomes were markers of glycemia and all measurements were taken at 2 or 4-weekly intervals. At the end of 16 weeks, both groups had significantly lower BMI (q (Time) = 1.92 ×10-42, β = -0.02) compared with baseline, with minimal difference between groups. The IG had significantly greater reductions in LDL cholesterol (q (Treatment×Time) = 0.01, β = -0.16), total cholesterol (q (Treatment×Time) = 0.02, β = -0.3) and HbA1c (q (Treatment×Time) = 0.04, β = -0.004) compared with CG, alongside increases in fiber degrading species in IG, mediated through metabolites such as bile acids and amino acids. A legume-enriched, multicomponent intervention diet can improve metabolic health in a prediabetes population, in addition to benefits obtained from calorie restriction alone, partially mediated through changes in gut microbial composition and function. Trial registration: Clinical Trials NCT04745702. |
| format | Article |
| id | doaj-art-6f3c33c2f50640be8bc27dfe15b72d57 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Nature Communications |
| spelling | doaj-art-6f3c33c2f50640be8bc27dfe15b72d572025-01-26T12:42:37ZengNature PortfolioNature Communications2041-17232025-01-0116112010.1038/s41467-025-56084-6A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trialXiaorong Wu0Alvin Surya Tjahyo1Vera Sergeyevna Brok Volchanskaya2Long Hui Wong3Xianning Lai4Yi Ning Yong5Farhana Osman6Shia Lyn Tay7Priya Govindharajulu8Shalini Ponnalagu9Rachel Tso10Hwee Sze Teo11Kaijie Khoo12Huan Fan13Chew Chan Goh14Clara Poh Lian Yap15Melvin Khee-Shing Leow16Christiani Jeyakumar Henry17Sumanto Haldar18Kevin Junliang Lim19WIL@NUS Corporate Laboratory, National University of Singapore, Centre for Translational MedicineClinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR)WIL@NUS Corporate Laboratory, National University of Singapore, Centre for Translational MedicineWIL@NUS Corporate Laboratory, National University of Singapore, Centre for Translational MedicineWIL@NUS Corporate Laboratory, National University of Singapore, Centre for Translational MedicineClinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR)Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR)Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR)Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR)Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR)Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR)Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR)WIL@NUS Corporate Laboratory, National University of Singapore, Centre for Translational MedicineWIL@NUS Corporate Laboratory, National University of Singapore, Centre for Translational MedicineWIL@NUS Corporate Laboratory, National University of Singapore, Centre for Translational MedicineWIL@NUS Corporate Laboratory, National University of Singapore, Centre for Translational MedicineClinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR)Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR)Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR)WIL@NUS Corporate Laboratory, National University of Singapore, Centre for Translational MedicineAbstract Healthy dietary patterns rich in legumes can improve metabolic health, although their additional benefits in conjunction with calorie restriction have not been well-established. We investigated effects of a calorie-restricted, legume-enriched, multicomponent intervention diet compared with a calorie-restricted control diet in 127 Chinese prediabetes participants, living in Singapore. The study was a 16-week, single-blind, parallel-design, randomized controlled trial (n = 63 intervention group (IG), n = 64 control group (CG); mean ± SD age 62.2 ± 6.3 years, BMI 23.8 ± 2.6 kg/m2). Primary outcomes were markers of glycemia and all measurements were taken at 2 or 4-weekly intervals. At the end of 16 weeks, both groups had significantly lower BMI (q (Time) = 1.92 ×10-42, β = -0.02) compared with baseline, with minimal difference between groups. The IG had significantly greater reductions in LDL cholesterol (q (Treatment×Time) = 0.01, β = -0.16), total cholesterol (q (Treatment×Time) = 0.02, β = -0.3) and HbA1c (q (Treatment×Time) = 0.04, β = -0.004) compared with CG, alongside increases in fiber degrading species in IG, mediated through metabolites such as bile acids and amino acids. A legume-enriched, multicomponent intervention diet can improve metabolic health in a prediabetes population, in addition to benefits obtained from calorie restriction alone, partially mediated through changes in gut microbial composition and function. Trial registration: Clinical Trials NCT04745702.https://doi.org/10.1038/s41467-025-56084-6 |
| spellingShingle | Xiaorong Wu Alvin Surya Tjahyo Vera Sergeyevna Brok Volchanskaya Long Hui Wong Xianning Lai Yi Ning Yong Farhana Osman Shia Lyn Tay Priya Govindharajulu Shalini Ponnalagu Rachel Tso Hwee Sze Teo Kaijie Khoo Huan Fan Chew Chan Goh Clara Poh Lian Yap Melvin Khee-Shing Leow Christiani Jeyakumar Henry Sumanto Haldar Kevin Junliang Lim A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial Nature Communications |
| title | A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial |
| title_full | A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial |
| title_fullStr | A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial |
| title_full_unstemmed | A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial |
| title_short | A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial |
| title_sort | legume enriched diet improves metabolic health in prediabetes mediated through gut microbiome a randomized controlled trial |
| url | https://doi.org/10.1038/s41467-025-56084-6 |
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