HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s Macroglobulinemia
Ibrutinib is a major new addition to the therapeutic armamentarium for chronic lymphocytic leukemia, mantle cell lymphoma, Waldenstrom’s macroglobulinemia, and chronic graft versus host disease. Though ibrutinib has proven to be a revolutionary new small molecule agent, and has relatively minimal to...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2020/6516037 |
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| _version_ | 1832553947553857536 |
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| author | Mark R. Wallace |
| author_facet | Mark R. Wallace |
| author_sort | Mark R. Wallace |
| collection | DOAJ |
| description | Ibrutinib is a major new addition to the therapeutic armamentarium for chronic lymphocytic leukemia, mantle cell lymphoma, Waldenstrom’s macroglobulinemia, and chronic graft versus host disease. Though ibrutinib has proven to be a revolutionary new small molecule agent, and has relatively minimal toxicity as compared to traditional chemotherapy, infections have emerged as a major complication of therapy. While fungal infections have been the most problematic (including CNS aspergillosis), zoster, hepatitis B reactivation, and chronic hepatitis E have been reported in association with ibrutinib therapy. This report describes a case of herpes encephalitis in an 86-year-old Waldenstrom’s patient receiving ibrutinib and speculates as to whether this late life encephalitis may have been related to ibrutinib. |
| format | Article |
| id | doaj-art-6f1e12cd5cba45edbb5c56c9d6ec7bc7 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-6f1e12cd5cba45edbb5c56c9d6ec7bc72025-02-03T05:52:44ZengWileyCase Reports in Infectious Diseases2090-66252090-66332020-01-01202010.1155/2020/65160376516037HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s MacroglobulinemiaMark R. Wallace0Skagit Valley Hospital, 360 Hospital Parkway, My Vernon, WA 98273, USAIbrutinib is a major new addition to the therapeutic armamentarium for chronic lymphocytic leukemia, mantle cell lymphoma, Waldenstrom’s macroglobulinemia, and chronic graft versus host disease. Though ibrutinib has proven to be a revolutionary new small molecule agent, and has relatively minimal toxicity as compared to traditional chemotherapy, infections have emerged as a major complication of therapy. While fungal infections have been the most problematic (including CNS aspergillosis), zoster, hepatitis B reactivation, and chronic hepatitis E have been reported in association with ibrutinib therapy. This report describes a case of herpes encephalitis in an 86-year-old Waldenstrom’s patient receiving ibrutinib and speculates as to whether this late life encephalitis may have been related to ibrutinib.http://dx.doi.org/10.1155/2020/6516037 |
| spellingShingle | Mark R. Wallace HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s Macroglobulinemia Case Reports in Infectious Diseases |
| title | HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s Macroglobulinemia |
| title_full | HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s Macroglobulinemia |
| title_fullStr | HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s Macroglobulinemia |
| title_full_unstemmed | HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s Macroglobulinemia |
| title_short | HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s Macroglobulinemia |
| title_sort | hsv 1 encephalitis in an elderly man receiving ibrutinib for waldenstrom s macroglobulinemia |
| url | http://dx.doi.org/10.1155/2020/6516037 |
| work_keys_str_mv | AT markrwallace hsv1encephalitisinanelderlymanreceivingibrutinibforwaldenstromsmacroglobulinemia |