IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine releas...
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629359891162 |
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| _version_ | 1832562673332518912 |
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| author | U. Westin E. Lundberg K. Ohlsson |
| author_facet | U. Westin E. Lundberg K. Ohlsson |
| author_sort | U. Westin |
| collection | DOAJ |
| description | The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release. |
| format | Article |
| id | doaj-art-6f13f03a40364647a25a138903ffc189 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6f13f03a40364647a25a138903ffc1892025-02-03T01:22:00ZengWileyMediators of Inflammation0962-93511466-18611998-01-017321722010.1080/09629359891162IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous releaseU. Westin0E. Lundberg1K. Ohlsson2Department of Otolaryngology and Head and Neck Surgery, University Hospital of Malmö, University of Lund, Malmö SE-205 02, SwedenDepartment of Surgical Pathophysiology, University Hospital of Malmö, University of Lund, Malmö SE-205 02, SwedenDepartment of Surgical Pathophysiology, University Hospital of Malmö, University of Lund, Malmö SE-205 02, SwedenThe secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.http://dx.doi.org/10.1080/09629359891162SLPIIgEchymasehistaminenasal mucosa. |
| spellingShingle | U. Westin E. Lundberg K. Ohlsson IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release Mediators of Inflammation SLPI IgE chymase histamine nasal mucosa. |
| title | IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release |
| title_full | IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release |
| title_fullStr | IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release |
| title_full_unstemmed | IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release |
| title_short | IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release |
| title_sort | ige mediated histamine release from nasal mucosa is inhibited by slpi secretory leukocyte protease inhibitor to the level of spontaneous release |
| topic | SLPI IgE chymase histamine nasal mucosa. |
| url | http://dx.doi.org/10.1080/09629359891162 |
| work_keys_str_mv | AT uwestin igemediatedhistaminereleasefromnasalmucosaisinhibitedbyslpisecretoryleukocyteproteaseinhibitortothelevelofspontaneousrelease AT elundberg igemediatedhistaminereleasefromnasalmucosaisinhibitedbyslpisecretoryleukocyteproteaseinhibitortothelevelofspontaneousrelease AT kohlsson igemediatedhistaminereleasefromnasalmucosaisinhibitedbyslpisecretoryleukocyteproteaseinhibitortothelevelofspontaneousrelease |