Neuroprotective effects of ethanol extraction from Rubia yunnanensis Diels on chronic cerebral hypoperfusion: modulation of the System Xc-/GSH/GPX4 axis to alleviate oxidative stress and ferroptosis

Neuroprotective effects of ethanol extraction from Rubia yunnanensis Diels on chronic cerebral hypoperfusion: modulation of the System Xc-/GSH/GPX4 axis to alleviate oxidative stress and ferroptosis

IntroductionVascular dementia (VD) is a neurodegenerative disease caused by chronic cerebral hypoperfusion (CCH), which considerably impact patients’ quality of life. Ethanol extraction from Rubia yunnanensis (RY-A) has gained attention for its potential neuroprotective effects, but its effects and...

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Bibliographic Details
Main Authors:	Jianghao Cheng, Xiaoxia Ma, Jie Tao, Xiaoli Jiang, Pu Chen, Xiaohua Duan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Pharmacology
Subjects:	Rubia yunnanensis chronic cerebral hypoperfusion System Xc-/GSH/Gpx4 serum pharmacochemistry metabolomic transcriptomic
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1552228/full
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