Serum Cytokine Profiles in Children with Crohn’s Disease
Crohn’s disease (CD) is a chronic inflammatory bowel disease that can be diagnosed at any age. There are two major patient groups based on diagnosis of this disease, before or after the age of 20 (juvenile/adolescent or adult), with disease progression in adults usually milder than in juvenile CD pa...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/7420127 |
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| _version_ | 1832566212733698048 |
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| author | Ekaterina Vasilyeva Sayar Abdulkhakov Georgi Cherepnev Ekaterina Martynova Irina Mayanskaya Alina Valeeva Rustam Abdulkhakov Dilyara Safina Svetlana Khaiboullina Albert Rizvanov |
| author_facet | Ekaterina Vasilyeva Sayar Abdulkhakov Georgi Cherepnev Ekaterina Martynova Irina Mayanskaya Alina Valeeva Rustam Abdulkhakov Dilyara Safina Svetlana Khaiboullina Albert Rizvanov |
| author_sort | Ekaterina Vasilyeva |
| collection | DOAJ |
| description | Crohn’s disease (CD) is a chronic inflammatory bowel disease that can be diagnosed at any age. There are two major patient groups based on diagnosis of this disease, before or after the age of 20 (juvenile/adolescent or adult), with disease progression in adults usually milder than in juvenile CD patients. Immune mechanisms have been suggested to play an important role in CD pathogenesis, with cytokines governing the development of the immune response. Upregulation of inflammatory cytokines in serum of juvenile and adult CD patients has been documented; still little is known about age-dependent differences in serum cytokine profiles of CD patients. We applied multiplex technology to analyze serum levels of 12 cytokines in juveniles and adults. We show that during the acute stage of the disease all CD patients have high serum levels of CXCL10, which remains upregulated during remission. Increased serum levels of TNF-α and IL-6 during the acute stage was characteristic of juvenile CD patients, whereas adult CD patients had upregulated levels of GM-CSF and IFN-γ. Taken together, these results demonstrate age-dependent differences in cytokine profiles, which may affect the pathogenesis of CD in patients at different ages of disease onset. |
| format | Article |
| id | doaj-art-6f0b155e70f144a4b30b889867bb1920 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6f0b155e70f144a4b30b889867bb19202025-02-03T01:04:50ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/74201277420127Serum Cytokine Profiles in Children with Crohn’s DiseaseEkaterina Vasilyeva0Sayar Abdulkhakov1Georgi Cherepnev2Ekaterina Martynova3Irina Mayanskaya4Alina Valeeva5Rustam Abdulkhakov6Dilyara Safina7Svetlana Khaiboullina8Albert Rizvanov9Volga Region Federal Medical Research Center of the Ministry of Public Health, Nizhny Novgorod, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, RussiaVolga Region Federal Medical Research Center of the Ministry of Public Health, Nizhny Novgorod, RussiaKazan State Medical University, Kazan, RussiaKazan State Medical University, Kazan, RussiaKazan State Medical University, Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, RussiaCrohn’s disease (CD) is a chronic inflammatory bowel disease that can be diagnosed at any age. There are two major patient groups based on diagnosis of this disease, before or after the age of 20 (juvenile/adolescent or adult), with disease progression in adults usually milder than in juvenile CD patients. Immune mechanisms have been suggested to play an important role in CD pathogenesis, with cytokines governing the development of the immune response. Upregulation of inflammatory cytokines in serum of juvenile and adult CD patients has been documented; still little is known about age-dependent differences in serum cytokine profiles of CD patients. We applied multiplex technology to analyze serum levels of 12 cytokines in juveniles and adults. We show that during the acute stage of the disease all CD patients have high serum levels of CXCL10, which remains upregulated during remission. Increased serum levels of TNF-α and IL-6 during the acute stage was characteristic of juvenile CD patients, whereas adult CD patients had upregulated levels of GM-CSF and IFN-γ. Taken together, these results demonstrate age-dependent differences in cytokine profiles, which may affect the pathogenesis of CD in patients at different ages of disease onset.http://dx.doi.org/10.1155/2016/7420127 |
| spellingShingle | Ekaterina Vasilyeva Sayar Abdulkhakov Georgi Cherepnev Ekaterina Martynova Irina Mayanskaya Alina Valeeva Rustam Abdulkhakov Dilyara Safina Svetlana Khaiboullina Albert Rizvanov Serum Cytokine Profiles in Children with Crohn’s Disease Mediators of Inflammation |
| title | Serum Cytokine Profiles in Children with Crohn’s Disease |
| title_full | Serum Cytokine Profiles in Children with Crohn’s Disease |
| title_fullStr | Serum Cytokine Profiles in Children with Crohn’s Disease |
| title_full_unstemmed | Serum Cytokine Profiles in Children with Crohn’s Disease |
| title_short | Serum Cytokine Profiles in Children with Crohn’s Disease |
| title_sort | serum cytokine profiles in children with crohn s disease |
| url | http://dx.doi.org/10.1155/2016/7420127 |
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