Effect of Glycine on Lead Mobilization, Lead-Induced Oxidative Stress, and Hepatic Toxicity in Rats
The effectiveness of glycine in treating experimental lead intoxication was examined in rats. Male Wistar rats were exposed to 3 g/L lead acetate in drinking water for 5 weeks and treated thereafter with glycin...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2011/430539 |
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| author | Yolanda Alcaraz-Contreras Lourdes Garza-Ocañas Katya Carcaño-Díaz Xóchitl Sofía Ramírez-Gómez |
| author_facet | Yolanda Alcaraz-Contreras Lourdes Garza-Ocañas Katya Carcaño-Díaz Xóchitl Sofía Ramírez-Gómez |
| author_sort | Yolanda Alcaraz-Contreras |
| collection | DOAJ |
| description | The effectiveness of glycine in treating experimental lead intoxication
was examined in rats. Male Wistar rats were exposed to 3 g/L
lead acetate in drinking water for 5 weeks and treated thereafter with
glycine (100 and 500 mg/kg, orally) once daily for
5 days or glycine (1000 mg/kg, orally) once daily for
28 days. The effect of these treatments on parameters
indicative of oxidative stress (glutathione and malondialdehyde
levels), the activity of blood 𝛿-aminolevulinic acid dehydratase, and lead concentration in
blood, liver, kidney, brain, and bone were investigated. Liver samples
were observed for histopathological changes. Glycine was found to be
effective in (1) increasing glutathione levels; (2) reducing
malondialdehyde levels; (3) decreasing lead levels in bone with the
highest dose. However, glycine had no effect on lead mobilization when
100 and 500 mg/kg glycine were administered. In
microscopic examination, glycine showed a protective effect against
lead intoxication. |
| format | Article |
| id | doaj-art-6f06169f6f254634b4ebbfb8aff8df40 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-6f06169f6f254634b4ebbfb8aff8df402025-02-03T01:26:28ZengWileyJournal of Toxicology1687-81911687-82052011-01-01201110.1155/2011/430539430539Effect of Glycine on Lead Mobilization, Lead-Induced Oxidative Stress, and Hepatic Toxicity in RatsYolanda Alcaraz-Contreras0Lourdes Garza-Ocañas1Katya Carcaño-Díaz2Xóchitl Sofía Ramírez-Gómez3División de Ciencias Naturales y Exactas, Departamento de Farmacia, Universidad de Guanajuato, Noria Alta s/n, 36050 Guanajuato, Gto., MexicoDepartamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Gonzalitos 235 Norte, Col Mitras Centro, 64460 Monterrey Nuevo León, MexicoDepartamento de Histología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey Nuevo León, MexicoDepartamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Gonzalitos 235 Norte, Col Mitras Centro, 64460 Monterrey Nuevo León, MexicoThe effectiveness of glycine in treating experimental lead intoxication was examined in rats. Male Wistar rats were exposed to 3 g/L lead acetate in drinking water for 5 weeks and treated thereafter with glycine (100 and 500 mg/kg, orally) once daily for 5 days or glycine (1000 mg/kg, orally) once daily for 28 days. The effect of these treatments on parameters indicative of oxidative stress (glutathione and malondialdehyde levels), the activity of blood 𝛿-aminolevulinic acid dehydratase, and lead concentration in blood, liver, kidney, brain, and bone were investigated. Liver samples were observed for histopathological changes. Glycine was found to be effective in (1) increasing glutathione levels; (2) reducing malondialdehyde levels; (3) decreasing lead levels in bone with the highest dose. However, glycine had no effect on lead mobilization when 100 and 500 mg/kg glycine were administered. In microscopic examination, glycine showed a protective effect against lead intoxication.http://dx.doi.org/10.1155/2011/430539 |
| spellingShingle | Yolanda Alcaraz-Contreras Lourdes Garza-Ocañas Katya Carcaño-Díaz Xóchitl Sofía Ramírez-Gómez Effect of Glycine on Lead Mobilization, Lead-Induced Oxidative Stress, and Hepatic Toxicity in Rats Journal of Toxicology |
| title | Effect of Glycine on Lead Mobilization, Lead-Induced
Oxidative Stress, and Hepatic Toxicity in Rats |
| title_full | Effect of Glycine on Lead Mobilization, Lead-Induced
Oxidative Stress, and Hepatic Toxicity in Rats |
| title_fullStr | Effect of Glycine on Lead Mobilization, Lead-Induced
Oxidative Stress, and Hepatic Toxicity in Rats |
| title_full_unstemmed | Effect of Glycine on Lead Mobilization, Lead-Induced
Oxidative Stress, and Hepatic Toxicity in Rats |
| title_short | Effect of Glycine on Lead Mobilization, Lead-Induced
Oxidative Stress, and Hepatic Toxicity in Rats |
| title_sort | effect of glycine on lead mobilization lead induced oxidative stress and hepatic toxicity in rats |
| url | http://dx.doi.org/10.1155/2011/430539 |
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