Effect of Glycine on Lead Mobilization, Lead-Induced Oxidative Stress, and Hepatic Toxicity in Rats
The effectiveness of glycine in treating experimental lead intoxication was examined in rats. Male Wistar rats were exposed to 3 g/L lead acetate in drinking water for 5 weeks and treated thereafter with glycin...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2011/430539 |
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| Summary: | The effectiveness of glycine in treating experimental lead intoxication
was examined in rats. Male Wistar rats were exposed to 3 g/L
lead acetate in drinking water for 5 weeks and treated thereafter with
glycine (100 and 500 mg/kg, orally) once daily for
5 days or glycine (1000 mg/kg, orally) once daily for
28 days. The effect of these treatments on parameters
indicative of oxidative stress (glutathione and malondialdehyde
levels), the activity of blood 𝛿-aminolevulinic acid dehydratase, and lead concentration in
blood, liver, kidney, brain, and bone were investigated. Liver samples
were observed for histopathological changes. Glycine was found to be
effective in (1) increasing glutathione levels; (2) reducing
malondialdehyde levels; (3) decreasing lead levels in bone with the
highest dose. However, glycine had no effect on lead mobilization when
100 and 500 mg/kg glycine were administered. In
microscopic examination, glycine showed a protective effect against
lead intoxication. |
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| ISSN: | 1687-8191 1687-8205 |