Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy
Multiple myeloma is a type of plasma cell neoplasm that produces monoclonal immunoglobulin. Multiple myeloma is known to cause immunoglobulin light-chain (AL) amyloidosis, which frequently involves the kidney and heart. Bone pain or fractures caused by osteolytic lesions and physical disorders relat...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/5533993 |
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| author | Katsuya Endo Takehito Ito Jun Nomura Keigo Murakami Shiho Kondo Tomonori Satoh Daisuke Fukushi Yuki Yoshino Yoshiteru Sasaki Atsuko Takasu Takayuki Kogure Morihisa Hirota Takayoshi Meguro Kazuhiro Murakami Junichi Kameoka Kennichi Satoh |
| author_facet | Katsuya Endo Takehito Ito Jun Nomura Keigo Murakami Shiho Kondo Tomonori Satoh Daisuke Fukushi Yuki Yoshino Yoshiteru Sasaki Atsuko Takasu Takayuki Kogure Morihisa Hirota Takayoshi Meguro Kazuhiro Murakami Junichi Kameoka Kennichi Satoh |
| author_sort | Katsuya Endo |
| collection | DOAJ |
| description | Multiple myeloma is a type of plasma cell neoplasm that produces monoclonal immunoglobulin. Multiple myeloma is known to cause immunoglobulin light-chain (AL) amyloidosis, which frequently involves the kidney and heart. Bone pain or fractures caused by osteolytic lesions and physical disorders related to renal or cardiac AL amyloidosis are major initial symptoms in multiple myeloma. Multiple myeloma diagnosed from the gastrointestinal symptoms is rare. We report a case of an 80-year-old man with multiple myeloma accompanied by gastrointestinal AL amyloidosis and secondary protein-losing enteropathy. The diagnostic process was suggestive, in that diarrhea and refractory leg edema related to protein-losing enteropathy were the primary symptoms and the trigger for making a sequential diagnosis of gastrointestinal AL amyloidosis and underlying multiple myeloma. This case is highly suggestive, in that multiple myeloma with gastrointestinal AL amyloidosis should be considered one of the background diseases of protein-losing enteropathy. |
| format | Article |
| id | doaj-art-6f02059977ac476e8b36d6612adb6b66 |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-6f02059977ac476e8b36d6612adb6b662025-02-03T06:43:34ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362021-01-01202110.1155/2021/55339935533993Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing EnteropathyKatsuya Endo0Takehito Ito1Jun Nomura2Keigo Murakami3Shiho Kondo4Tomonori Satoh5Daisuke Fukushi6Yuki Yoshino7Yoshiteru Sasaki8Atsuko Takasu9Takayuki Kogure10Morihisa Hirota11Takayoshi Meguro12Kazuhiro Murakami13Junichi Kameoka14Kennichi Satoh15Division of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Hematology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Pathology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Pathology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Hematology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, JapanMultiple myeloma is a type of plasma cell neoplasm that produces monoclonal immunoglobulin. Multiple myeloma is known to cause immunoglobulin light-chain (AL) amyloidosis, which frequently involves the kidney and heart. Bone pain or fractures caused by osteolytic lesions and physical disorders related to renal or cardiac AL amyloidosis are major initial symptoms in multiple myeloma. Multiple myeloma diagnosed from the gastrointestinal symptoms is rare. We report a case of an 80-year-old man with multiple myeloma accompanied by gastrointestinal AL amyloidosis and secondary protein-losing enteropathy. The diagnostic process was suggestive, in that diarrhea and refractory leg edema related to protein-losing enteropathy were the primary symptoms and the trigger for making a sequential diagnosis of gastrointestinal AL amyloidosis and underlying multiple myeloma. This case is highly suggestive, in that multiple myeloma with gastrointestinal AL amyloidosis should be considered one of the background diseases of protein-losing enteropathy.http://dx.doi.org/10.1155/2021/5533993 |
| spellingShingle | Katsuya Endo Takehito Ito Jun Nomura Keigo Murakami Shiho Kondo Tomonori Satoh Daisuke Fukushi Yuki Yoshino Yoshiteru Sasaki Atsuko Takasu Takayuki Kogure Morihisa Hirota Takayoshi Meguro Kazuhiro Murakami Junichi Kameoka Kennichi Satoh Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy Case Reports in Gastrointestinal Medicine |
| title | Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy |
| title_full | Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy |
| title_fullStr | Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy |
| title_full_unstemmed | Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy |
| title_short | Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy |
| title_sort | suggestive diagnostic process in a case of multiple myeloma with gastrointestinal immunoglobulin light chain amyloidosis accompanied by protein losing enteropathy |
| url | http://dx.doi.org/10.1155/2021/5533993 |
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