Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus: Case Report and Review of the Literature
Pancreatic neuroendocrine tumors (NETs) are extremely rare, and although insulinomas are the commonest, less than 10% of insulinomas are malignant. Most patients with insulinomas present with neuroglycopenic symptoms and weight gain attributable to insulin excess. Here, we report a case where a 67-y...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2011/124078 |
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| author | Noormuhammad Oosman Abbasakoor Marie Louise Healy Donal O'Shea Donal Maguire Cian Muldoon Kieran Sheahan Dermot O'Toole |
| author_facet | Noormuhammad Oosman Abbasakoor Marie Louise Healy Donal O'Shea Donal Maguire Cian Muldoon Kieran Sheahan Dermot O'Toole |
| author_sort | Noormuhammad Oosman Abbasakoor |
| collection | DOAJ |
| description | Pancreatic neuroendocrine tumors (NETs) are extremely rare, and although insulinomas are the commonest, less than 10% of insulinomas are malignant. Most patients with insulinomas present with neuroglycopenic symptoms and weight gain attributable to insulin excess. Here, we report a case where a 67-year-old lady with a background history of type 2 diabetes mellitus and breakthrough hyperinsulinism who presented with coma. The biochemical profile revealed features typical of insulinoma, and CT and endosonography confirmed a pancreatic tumor with large volume right-sided liver metastases (biopsy confirming a neuroendocrine tumor). The patient underwent successful one-step RO surgical resection, distal pancreatectomy, splenectomy, and right hepatectomy, and 9 months postoperatively, she remains free of recurrent disease. She remains a diabetic. |
| format | Article |
| id | doaj-art-6efce231850e4aebb8c2a2e08d302259 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6efce231850e4aebb8c2a2e08d3022592025-02-03T01:30:59ZengWileyInternational Journal of Endocrinology1687-83371687-83452011-01-01201110.1155/2011/124078124078Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus: Case Report and Review of the LiteratureNoormuhammad Oosman Abbasakoor0Marie Louise Healy1Donal O'Shea2Donal Maguire3Cian Muldoon4Kieran Sheahan5Dermot O'Toole6Department of Endocrinology, St. James' Hospital, Dublin 8, IrelandDepartment of Endocrinology, St. James' Hospital, Dublin 8, IrelandDepartment of Endocrinology, St. Vincent's University Hospital, Dublin 4, IrelandDepartment of Surgery, St. Vincent's University Hospital, Dublin 4, IrelandDepartment of Pathology, St. James' Hospital, Dublin 8, IrelandDepartment of Pathology, St. Vincent's University Hospital, Dublin 4, IrelandDepartment of Gastroenterology, St. James' Hospital, Dublin 8, IrelandPancreatic neuroendocrine tumors (NETs) are extremely rare, and although insulinomas are the commonest, less than 10% of insulinomas are malignant. Most patients with insulinomas present with neuroglycopenic symptoms and weight gain attributable to insulin excess. Here, we report a case where a 67-year-old lady with a background history of type 2 diabetes mellitus and breakthrough hyperinsulinism who presented with coma. The biochemical profile revealed features typical of insulinoma, and CT and endosonography confirmed a pancreatic tumor with large volume right-sided liver metastases (biopsy confirming a neuroendocrine tumor). The patient underwent successful one-step RO surgical resection, distal pancreatectomy, splenectomy, and right hepatectomy, and 9 months postoperatively, she remains free of recurrent disease. She remains a diabetic.http://dx.doi.org/10.1155/2011/124078 |
| spellingShingle | Noormuhammad Oosman Abbasakoor Marie Louise Healy Donal O'Shea Donal Maguire Cian Muldoon Kieran Sheahan Dermot O'Toole Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus: Case Report and Review of the Literature International Journal of Endocrinology |
| title | Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus: Case Report and Review of the Literature |
| title_full | Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus: Case Report and Review of the Literature |
| title_fullStr | Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus: Case Report and Review of the Literature |
| title_full_unstemmed | Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus: Case Report and Review of the Literature |
| title_short | Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus: Case Report and Review of the Literature |
| title_sort | metastatic insulinoma in a patient with type 2 diabetes mellitus case report and review of the literature |
| url | http://dx.doi.org/10.1155/2011/124078 |
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