In Situ Transformable Nanoparticle Effectively Suppresses Bladder Cancer by Damaging Mitochondria and Blocking Mitochondrial Autophagy Flux

In Situ Transformable Nanoparticle Effectively Suppresses Bladder Cancer by Damaging Mitochondria and Blocking Mitochondrial Autophagy Flux

Abstract Tumor therapeutic strategies based on mitochondrial damage have become an emerging trend. However, the low drug delivery efficiency caused by lysosomal sequestration and the activation of protective mitochondrial autophagy severely restricts the therapeutic efficacy. Herein, an in situ tran...

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Bibliographic Details
Main Authors: Yulin Lv, Benli Song, Guang Yang, Yuting Wang, Zeyu Wu, Minggui Si, Zongzheng Yang, Huilin Chen, Chen Liu, Min Li, Yinshi Zhang, Zengying Qiao, Lu Wang, Wanhai Xu
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
lysosomal escape
mitochondria damage
mitochondrial autophagy
self‐assembly
sonodynamic therapy
Online Access:https://doi.org/10.1002/advs.202409425
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