Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis

Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis

Abstract The caseinolytic protease (Clp) system has recently emerged as a promising anti-tuberculosis target. The anti-cancer drug bortezomib exhibits potent anti-mycobacterial activity and binds to Mycobacterium tuberculosis (Mtb) Clp protease complexes. We determine cryo-EM structures of Mtb ClpP1...

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Main Authors: Biao Zhou, Yamin Gao, Heyu Zhao, Banghui Liu, Han Zhang, Cuiting Fang, Hang Yuan, Jingjing Wang, Zimu Li, Yi Zhao, Xiaodong Huang, Xiyue Wang, A. Sofia. F. Oliveira, James Spencer, Adrian J. Mulholland, Steven G. Burston, Jinxing Hu, Ning Su, Xinwen Chen, Jun He, Tianyu Zhang, Xiaoli Xiong
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58410-4
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