An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass
<italic>Objective:</italic> Brain-body interfaces (BBIs) have emerged as a very promising solution for restoring voluntary hand control in people with upper-limb paralysis. The BBI module decoding motor commands from brain signals should provide the user with intuitive, accurate, and sta...
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IEEE
2024-01-01
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| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
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| Online Access: | https://ieeexplore.ieee.org/document/10478790/ |
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| author | E. Losanno M. Badi E. Roussinova A. Bogaard M. Delacombaz S. Shokur S. Micera |
| author_facet | E. Losanno M. Badi E. Roussinova A. Bogaard M. Delacombaz S. Shokur S. Micera |
| author_sort | E. Losanno |
| collection | DOAJ |
| description | <italic>Objective:</italic> Brain-body interfaces (BBIs) have emerged as a very promising solution for restoring voluntary hand control in people with upper-limb paralysis. The BBI module decoding motor commands from brain signals should provide the user with intuitive, accurate, and stable control. Here, we present a preliminary investigation in a monkey of a brain decoding strategy based on the direct coupling between the activity of intrinsic neural ensembles and output variables, aiming at achieving ease of learning and long-term robustness. <italic>Results:</italic> We identified an intrinsic low-dimensional space (called manifold) capturing the co-variation patterns of the monkey's neural activity associated to reach-to-grasp movements. We then tested the animal's ability to directly control a computer cursor using cortical activation along the manifold axes. By daily recalibrating only scaling factors, we achieved rapid learning and stable high performance in simple, incremental 2D tasks over more than 12 weeks of experiments. Finally, we showed that this brain decoding strategy can be effectively coupled to peripheral nerve stimulation to trigger voluntary hand movements. <italic>Conclusions:</italic> These results represent a proof of concept of manifold-based direct control for BBI applications. |
| format | Article |
| id | doaj-art-6ee5a9d5b0c04efab0f54e8a818f208b |
| institution | Kabale University |
| issn | 2644-1276 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj-art-6ee5a9d5b0c04efab0f54e8a818f208b2025-01-30T00:03:33ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762024-01-01527128010.1109/OJEMB.2024.338147510478790An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural BypassE. Losanno0https://orcid.org/0000-0002-6234-375XM. Badi1https://orcid.org/0000-0002-5757-7367E. Roussinova2https://orcid.org/0009-0000-4387-6027A. Bogaard3https://orcid.org/0000-0002-3081-4633M. Delacombaz4S. Shokur5https://orcid.org/0000-0003-2251-7142S. Micera6https://orcid.org/0000-0003-4396-8217The Biorobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, ItalyBertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, SwitzerlandBertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, SwitzerlandDepartment of Neuroscience and Movement Sciences, Platform of Translational Neurosciences, Section of Medicine, Faculty of Sciences and Medicine, University of Fribourg, Fribourg, SwitzerlandDepartment of Neuroscience and Movement Sciences, Platform of Translational Neurosciences, Section of Medicine, Faculty of Sciences and Medicine, University of Fribourg, Fribourg, SwitzerlandBertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, SwitzerlandThe Biorobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy<italic>Objective:</italic> Brain-body interfaces (BBIs) have emerged as a very promising solution for restoring voluntary hand control in people with upper-limb paralysis. The BBI module decoding motor commands from brain signals should provide the user with intuitive, accurate, and stable control. Here, we present a preliminary investigation in a monkey of a brain decoding strategy based on the direct coupling between the activity of intrinsic neural ensembles and output variables, aiming at achieving ease of learning and long-term robustness. <italic>Results:</italic> We identified an intrinsic low-dimensional space (called manifold) capturing the co-variation patterns of the monkey's neural activity associated to reach-to-grasp movements. We then tested the animal's ability to directly control a computer cursor using cortical activation along the manifold axes. By daily recalibrating only scaling factors, we achieved rapid learning and stable high performance in simple, incremental 2D tasks over more than 12 weeks of experiments. Finally, we showed that this brain decoding strategy can be effectively coupled to peripheral nerve stimulation to trigger voluntary hand movements. <italic>Conclusions:</italic> These results represent a proof of concept of manifold-based direct control for BBI applications.https://ieeexplore.ieee.org/document/10478790/Brain-body interfacesdirect controlhand movement controlneural manifoldperipheral neurostimulation |
| spellingShingle | E. Losanno M. Badi E. Roussinova A. Bogaard M. Delacombaz S. Shokur S. Micera An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass IEEE Open Journal of Engineering in Medicine and Biology Brain-body interfaces direct control hand movement control neural manifold peripheral neurostimulation |
| title | An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass |
| title_full | An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass |
| title_fullStr | An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass |
| title_full_unstemmed | An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass |
| title_short | An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass |
| title_sort | investigation of manifold based direct control for a brain to body neural bypass |
| topic | Brain-body interfaces direct control hand movement control neural manifold peripheral neurostimulation |
| url | https://ieeexplore.ieee.org/document/10478790/ |
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