A double dissociation between semantic and spatial cognition in visual to default network pathways
Processing pathways between sensory and default mode network (DMN) regions support recognition, navigation, and memory but their organisation is not well understood. We show that functional subdivisions of visual cortex and DMN sit at opposing ends of parallel streams of information processing that...
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eLife Sciences Publications Ltd
2025-01-01
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| Online Access: | https://elifesciences.org/articles/94902 |
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| author | Tirso RJ Gonzalez Alam Katya Krieger-Redwood Dominika Varga Zhiyao Gao Aidan J Horner Tom Hartley Michel Thiebaut de Schotten Magdalena Sliwinska David Pitcher Daniel S Margulies Jonathan Smallwood Elizabeth Jefferies |
| author_facet | Tirso RJ Gonzalez Alam Katya Krieger-Redwood Dominika Varga Zhiyao Gao Aidan J Horner Tom Hartley Michel Thiebaut de Schotten Magdalena Sliwinska David Pitcher Daniel S Margulies Jonathan Smallwood Elizabeth Jefferies |
| author_sort | Tirso RJ Gonzalez Alam |
| collection | DOAJ |
| description | Processing pathways between sensory and default mode network (DMN) regions support recognition, navigation, and memory but their organisation is not well understood. We show that functional subdivisions of visual cortex and DMN sit at opposing ends of parallel streams of information processing that support visually mediated semantic and spatial cognition, providing convergent evidence from univariate and multivariate task responses, intrinsic functional and structural connectivity. Participants learned virtual environments consisting of buildings populated with objects, drawn from either a single semantic category or multiple categories. Later, they made semantic and spatial context decisions about these objects and buildings during functional magnetic resonance imaging. A lateral ventral occipital to fronto-temporal DMN pathway was primarily engaged by semantic judgements, while a medial visual to medial temporal DMN pathway supported spatial context judgements. These pathways had distinctive locations in functional connectivity space: the semantic pathway was both further from unimodal systems and more balanced between visual and auditory-motor regions compared with the spatial pathway. When semantic and spatial context information could be integrated (in buildings containing objects from a single category), regions at the intersection of these pathways responded, suggesting that parallel processing streams interact at multiple levels of the cortical hierarchy to produce coherent memory-guided cognition. |
| format | Article |
| id | doaj-art-6ed1db2f2439484da117fab2b53d7b44 |
| institution | Kabale University |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | eLife Sciences Publications Ltd |
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| series | eLife |
| spelling | doaj-art-6ed1db2f2439484da117fab2b53d7b442025-01-22T15:04:45ZengeLife Sciences Publications LtdeLife2050-084X2025-01-011310.7554/eLife.94902A double dissociation between semantic and spatial cognition in visual to default network pathwaysTirso RJ Gonzalez Alam0https://orcid.org/0000-0003-4510-2441Katya Krieger-Redwood1Dominika Varga2Zhiyao Gao3https://orcid.org/0000-0002-8909-8096Aidan J Horner4https://orcid.org/0000-0003-0882-9756Tom Hartley5Michel Thiebaut de Schotten6https://orcid.org/0000-0002-0329-1814Magdalena Sliwinska7David Pitcher8Daniel S Margulies9Jonathan Smallwood10Elizabeth Jefferies11Department of Psychology, University of York, North Yorkshire, United Kingdom; York Neuroimaging Centre, Innovation Way, Heslington, North Yorkshire, United Kingdom; School of Human and Behavioural Sciences, Bangor University, Gwynedd, Wales, UK, York, United KingdomDepartment of Psychology, University of York, North Yorkshire, United Kingdom; York Neuroimaging Centre, Innovation Way, Heslington, North Yorkshire, United KingdomSussex Neuroscience, School of Psychology, University of Sussex, Brighton and Hove, United StatesDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine Stanford, Stanford, United KingdomDepartment of Psychology, University of York, North Yorkshire, United Kingdom; York Neuroimaging Centre, Innovation Way, Heslington, North Yorkshire, United KingdomDepartment of Psychology, University of York, North Yorkshire, United Kingdom; York Neuroimaging Centre, Innovation Way, Heslington, North Yorkshire, United KingdomUniversity of Bordeaux, CNRS, CEA, IMN, Bordeaux, France; Brain Connectivity and Behaviour Laboratory, Sorbonne Universities, Paris, FranceDepartment of Psychology, Liverpool John Moores University, Liverpool, United KingdomDepartment of Psychology, University of York, North Yorkshire, United Kingdom; York Neuroimaging Centre, Innovation Way, Heslington, North Yorkshire, United KingdomIntegrative Neuroscience and Cognition Center (UMR 8002), Centre National de la Recherche Scientifique (CNRS) and Université de Paris, Paris, FranceDepartment of Psychology, Queen’s University, Kingston, Kingston, CanadaDepartment of Psychology, University of York, North Yorkshire, United Kingdom; York Neuroimaging Centre, Innovation Way, Heslington, North Yorkshire, United KingdomProcessing pathways between sensory and default mode network (DMN) regions support recognition, navigation, and memory but their organisation is not well understood. We show that functional subdivisions of visual cortex and DMN sit at opposing ends of parallel streams of information processing that support visually mediated semantic and spatial cognition, providing convergent evidence from univariate and multivariate task responses, intrinsic functional and structural connectivity. Participants learned virtual environments consisting of buildings populated with objects, drawn from either a single semantic category or multiple categories. Later, they made semantic and spatial context decisions about these objects and buildings during functional magnetic resonance imaging. A lateral ventral occipital to fronto-temporal DMN pathway was primarily engaged by semantic judgements, while a medial visual to medial temporal DMN pathway supported spatial context judgements. These pathways had distinctive locations in functional connectivity space: the semantic pathway was both further from unimodal systems and more balanced between visual and auditory-motor regions compared with the spatial pathway. When semantic and spatial context information could be integrated (in buildings containing objects from a single category), regions at the intersection of these pathways responded, suggesting that parallel processing streams interact at multiple levels of the cortical hierarchy to produce coherent memory-guided cognition.https://elifesciences.org/articles/94902default mode networkfMRInetworksvisionsemanticDMN |
| spellingShingle | Tirso RJ Gonzalez Alam Katya Krieger-Redwood Dominika Varga Zhiyao Gao Aidan J Horner Tom Hartley Michel Thiebaut de Schotten Magdalena Sliwinska David Pitcher Daniel S Margulies Jonathan Smallwood Elizabeth Jefferies A double dissociation between semantic and spatial cognition in visual to default network pathways eLife default mode network fMRI networks vision semantic DMN |
| title | A double dissociation between semantic and spatial cognition in visual to default network pathways |
| title_full | A double dissociation between semantic and spatial cognition in visual to default network pathways |
| title_fullStr | A double dissociation between semantic and spatial cognition in visual to default network pathways |
| title_full_unstemmed | A double dissociation between semantic and spatial cognition in visual to default network pathways |
| title_short | A double dissociation between semantic and spatial cognition in visual to default network pathways |
| title_sort | double dissociation between semantic and spatial cognition in visual to default network pathways |
| topic | default mode network fMRI networks vision semantic DMN |
| url | https://elifesciences.org/articles/94902 |
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