Ilex paraguariensis extract as an alternative to pain medications
Pain is a common and distressing symptom of many diseases and its clinical treatment generally involves analgesics and anti-inflammatory drugs. This study evaluated the toxicity of Ilex paraguariensis A. St.-Hil. (Aquifoliaceae) aqueous extract (leaves, petioles and branches) and its performance in...
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| Format: | Article |
| Language: | English |
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Sciendo
2021-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2021-0029 |
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| author | Nowacki Luciana C. Stechman-Neto José Schiefer Elberth M. Santos Andressa F. Stinghen Andréa E. M. Sassaki Guilherme L. De Souza Lauro M. Cristoff Killian E. De Souza Wesley M. |
| author_facet | Nowacki Luciana C. Stechman-Neto José Schiefer Elberth M. Santos Andressa F. Stinghen Andréa E. M. Sassaki Guilherme L. De Souza Lauro M. Cristoff Killian E. De Souza Wesley M. |
| author_sort | Nowacki Luciana C. |
| collection | DOAJ |
| description | Pain is a common and distressing symptom of many diseases and its clinical treatment generally involves analgesics and anti-inflammatory drugs. This study evaluated the toxicity of Ilex paraguariensis A. St.-Hil. (Aquifoliaceae) aqueous extract (leaves, petioles and branches) and its performance in a nociceptive response. Hepatotoxicity, psycho-stimulant test and evaluation of enzyme markers for liver damage were also tested. Chromatographic analysis by UPLC-MS demonstrated a series of isomeric monocaffeoylquinic acids, isomers of dicaffeoylquinic acid, flavonol glycosides, and saponins. Phase I and II of nociception were obtained for meloxicam, dexamethasone and aqueous Ilex paraguariensis extract. Ilex paraguariensis extract concentration was negatively correlated (R = –0.887) with alanine aminotransferase (p < 0.05) in acetaminophen-induced hepatotoxicity test, indicating hepatoprotective activity of this extract. Ilex paraguariensis extract also presented analgesic properties equivalent to drugs that already have proven efficacy. Notably, the administration of multiple doses of Ilex paraguariensis extract was considered safe from the therapeutic point of view. |
| format | Article |
| id | doaj-art-6ec79dfbfbd144fcbabc0a4a7a0097f6 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-6ec79dfbfbd144fcbabc0a4a7a0097f62025-02-02T17:46:44ZengSciendoActa Pharmaceutica1846-95582021-09-0171338339810.2478/acph-2021-0029acph-2021-0029Ilex paraguariensis extract as an alternative to pain medicationsNowacki Luciana C.0Stechman-Neto José1Schiefer Elberth M.2Santos Andressa F.3Stinghen Andréa E. M.4Sassaki Guilherme L.5De Souza Lauro M.6Cristoff Killian E.7De Souza Wesley M.8Pharmacology Department, Tuiuti University of Paraná, Curitiba, PR, BrazilPostgraduate Program in Communication Disorders, Tuiuti University of Paraná, CuritibaPR, BrazilGraduate Program in Electrical and Computer Engineering, Federal Technological University of Paraná Curitiba, PR, BrazilClinical Analysis Department, Federal University of Paraná, Curitiba, PR, BrazilBasic Pathology Department, Federal University of Paraná, Curitiba, PR, BrazilBiochemistry Department, Federal University of Paraná, Curitiba, PR, BrazilPequeno Principe College, Pelé Pequeno Principe Research Institute, Curitiba, PR, BrazilPostgraduate Program in Communication Disorders, Tuiuti University of Paraná, CuritibaPR, BrazilClinical Analysis Department, Federal University of Paraná, Curitiba, PR, BrazilPain is a common and distressing symptom of many diseases and its clinical treatment generally involves analgesics and anti-inflammatory drugs. This study evaluated the toxicity of Ilex paraguariensis A. St.-Hil. (Aquifoliaceae) aqueous extract (leaves, petioles and branches) and its performance in a nociceptive response. Hepatotoxicity, psycho-stimulant test and evaluation of enzyme markers for liver damage were also tested. Chromatographic analysis by UPLC-MS demonstrated a series of isomeric monocaffeoylquinic acids, isomers of dicaffeoylquinic acid, flavonol glycosides, and saponins. Phase I and II of nociception were obtained for meloxicam, dexamethasone and aqueous Ilex paraguariensis extract. Ilex paraguariensis extract concentration was negatively correlated (R = –0.887) with alanine aminotransferase (p < 0.05) in acetaminophen-induced hepatotoxicity test, indicating hepatoprotective activity of this extract. Ilex paraguariensis extract also presented analgesic properties equivalent to drugs that already have proven efficacy. Notably, the administration of multiple doses of Ilex paraguariensis extract was considered safe from the therapeutic point of view.https://doi.org/10.2478/acph-2021-0029nociceptionpainhepatoprotectiontoxicityilex paraguariensisaqueous extractuplcms |
| spellingShingle | Nowacki Luciana C. Stechman-Neto José Schiefer Elberth M. Santos Andressa F. Stinghen Andréa E. M. Sassaki Guilherme L. De Souza Lauro M. Cristoff Killian E. De Souza Wesley M. Ilex paraguariensis extract as an alternative to pain medications Acta Pharmaceutica nociception pain hepatoprotection toxicity ilex paraguariensis aqueous extract uplcms |
| title | Ilex paraguariensis extract as an alternative to pain medications |
| title_full | Ilex paraguariensis extract as an alternative to pain medications |
| title_fullStr | Ilex paraguariensis extract as an alternative to pain medications |
| title_full_unstemmed | Ilex paraguariensis extract as an alternative to pain medications |
| title_short | Ilex paraguariensis extract as an alternative to pain medications |
| title_sort | ilex paraguariensis extract as an alternative to pain medications |
| topic | nociception pain hepatoprotection toxicity ilex paraguariensis aqueous extract uplcms |
| url | https://doi.org/10.2478/acph-2021-0029 |
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