Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome
Background. Toxic shock syndrome is a potentially fatal toxin-mediated disease. The role of toxins in this clinical entity made us hypothesize that extracorporeal blood purification with CytoSorb® could play a beneficial role in the clinical management of toxic shock syndrome. This case report descr...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2017/3818407 |
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| author | Andrea Berkes Edit Szikszay János Kappelmayer Adrienne Kerényi Tamás Szabó László Ujhelyi Krisztina Bari György Balla József Balla |
| author_facet | Andrea Berkes Edit Szikszay János Kappelmayer Adrienne Kerényi Tamás Szabó László Ujhelyi Krisztina Bari György Balla József Balla |
| author_sort | Andrea Berkes |
| collection | DOAJ |
| description | Background. Toxic shock syndrome is a potentially fatal toxin-mediated disease. The role of toxins in this clinical entity made us hypothesize that extracorporeal blood purification with CytoSorb® could play a beneficial role in the clinical management of toxic shock syndrome. This case report describes the successful treatment of toxic shock syndrome using a combination of renal replacement therapy and hemadsorption in a pediatric patient. Case Presentation. A 5-year-old girl with Down’s syndrome presented with an inflamed area surrounding an insect bite, signs of systemic inflammation, and multiple organ failure. As previous attempts of immune modulation therapy were unsuccessful, renal replacement therapy was supplemented by the cytokine absorber CytoSorb. Treatment using this combination was associated with a rapid and significant stabilization in the hemodynamic situation and a decrease in inflammatory mediators within hours after the initiation of therapy. The application of CytoSorb therapy was simple and safe. Conclusion. The use of extracorporeal blood purification with CytoSorb proved potentially beneficial by removing toxins and inflammatory mediators in this case and could therefore play a role in the clinical management of toxic shock syndrome. Whether CytoSorb has the potential to even positively influence mortality in patients with toxic shock syndrome still needs to be confirmed. |
| format | Article |
| id | doaj-art-6ec0dd4bf6db477f8d8306a7350124fb |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-6ec0dd4bf6db477f8d8306a7350124fb2025-02-03T01:07:51ZengWileyCase Reports in Critical Care2090-64202090-64392017-01-01201710.1155/2017/38184073818407Use of Hemadsorption in a Case of Pediatric Toxic Shock SyndromeAndrea Berkes0Edit Szikszay1János Kappelmayer2Adrienne Kerényi3Tamás Szabó4László Ujhelyi5Krisztina Bari6György Balla7József Balla8Department of Pediatrics, University of Debrecen, Debrecen 4012, HungaryDepartment of Pediatrics, University of Debrecen, Debrecen 4012, HungaryInstitute of Laboratory Medicine, University of Debrecen, Debrecen 4012, HungaryInstitute of Laboratory Medicine, University of Debrecen, Debrecen 4012, HungaryDepartment of Pediatrics, University of Debrecen, Debrecen 4012, HungaryDepartment of Medicine, Faculty of Medicine, University of Debrecen, Debrecen 4012, HungaryFresenius Medical Care, NephroCare University of Debrecen, Debrecen 4012, HungaryDepartment of Pediatrics, University of Debrecen, Debrecen 4012, HungaryDepartment of Medicine, Faculty of Medicine, University of Debrecen, Debrecen 4012, HungaryBackground. Toxic shock syndrome is a potentially fatal toxin-mediated disease. The role of toxins in this clinical entity made us hypothesize that extracorporeal blood purification with CytoSorb® could play a beneficial role in the clinical management of toxic shock syndrome. This case report describes the successful treatment of toxic shock syndrome using a combination of renal replacement therapy and hemadsorption in a pediatric patient. Case Presentation. A 5-year-old girl with Down’s syndrome presented with an inflamed area surrounding an insect bite, signs of systemic inflammation, and multiple organ failure. As previous attempts of immune modulation therapy were unsuccessful, renal replacement therapy was supplemented by the cytokine absorber CytoSorb. Treatment using this combination was associated with a rapid and significant stabilization in the hemodynamic situation and a decrease in inflammatory mediators within hours after the initiation of therapy. The application of CytoSorb therapy was simple and safe. Conclusion. The use of extracorporeal blood purification with CytoSorb proved potentially beneficial by removing toxins and inflammatory mediators in this case and could therefore play a role in the clinical management of toxic shock syndrome. Whether CytoSorb has the potential to even positively influence mortality in patients with toxic shock syndrome still needs to be confirmed.http://dx.doi.org/10.1155/2017/3818407 |
| spellingShingle | Andrea Berkes Edit Szikszay János Kappelmayer Adrienne Kerényi Tamás Szabó László Ujhelyi Krisztina Bari György Balla József Balla Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome Case Reports in Critical Care |
| title | Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome |
| title_full | Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome |
| title_fullStr | Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome |
| title_full_unstemmed | Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome |
| title_short | Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome |
| title_sort | use of hemadsorption in a case of pediatric toxic shock syndrome |
| url | http://dx.doi.org/10.1155/2017/3818407 |
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