Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors.

Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors.

Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, is responsible for spinocerebellar ataxia type 1. Requirements for developing the disease are polyQ expansion, nuclear localization and phosphorylation of S776. Using a combination of bioinformatics, cell and structural...

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Bibliographic Details
Main Authors: Cesira de Chiara, Rajesh P Menon, Molly Strom, Toby J Gibson, Annalisa Pastore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0008372&type=printable
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