Collagen XVII: A Shared Antigen in Neurodermatological Interactions?
Collagen XVII is a nonfibril-forming transmembrane collagen, which functions as both a matrix protein and a cell-surface receptor. It is particularly copious in the skin, where it is known to be a structural component of hemidesmosomes. In addition, collagen XVII has been found to be present in the...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/240570 |
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| _version_ | 1832563918729379840 |
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| author | Allan Seppänen |
| author_facet | Allan Seppänen |
| author_sort | Allan Seppänen |
| collection | DOAJ |
| description | Collagen XVII is a nonfibril-forming transmembrane collagen, which functions as both a matrix protein and a cell-surface receptor. It is particularly copious in the skin, where it is known to be a structural component of hemidesmosomes. In addition, collagen XVII has been found to be present in the central nervous system, thus offering an explanation for the statistical association between bullous pemphigoid, in which autoimmunity is directed against dermal collagen XVII, and neurological diseases. In support of the hypothesis that collagen XVII serves as a shared antigen mediating an immune response between skin and brain, research on animal and human tissue, as well as numerous epidemiological and case studies, is presented. |
| format | Article |
| id | doaj-art-6eb2c3f9a72745f7b4743e58ef376bc1 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-6eb2c3f9a72745f7b4743e58ef376bc12025-02-03T01:12:18ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/240570240570Collagen XVII: A Shared Antigen in Neurodermatological Interactions?Allan Seppänen0Vanha Vaasa Hospital, 65380 Vaasa, FinlandCollagen XVII is a nonfibril-forming transmembrane collagen, which functions as both a matrix protein and a cell-surface receptor. It is particularly copious in the skin, where it is known to be a structural component of hemidesmosomes. In addition, collagen XVII has been found to be present in the central nervous system, thus offering an explanation for the statistical association between bullous pemphigoid, in which autoimmunity is directed against dermal collagen XVII, and neurological diseases. In support of the hypothesis that collagen XVII serves as a shared antigen mediating an immune response between skin and brain, research on animal and human tissue, as well as numerous epidemiological and case studies, is presented.http://dx.doi.org/10.1155/2013/240570 |
| spellingShingle | Allan Seppänen Collagen XVII: A Shared Antigen in Neurodermatological Interactions? Clinical and Developmental Immunology |
| title | Collagen XVII: A Shared Antigen in Neurodermatological Interactions? |
| title_full | Collagen XVII: A Shared Antigen in Neurodermatological Interactions? |
| title_fullStr | Collagen XVII: A Shared Antigen in Neurodermatological Interactions? |
| title_full_unstemmed | Collagen XVII: A Shared Antigen in Neurodermatological Interactions? |
| title_short | Collagen XVII: A Shared Antigen in Neurodermatological Interactions? |
| title_sort | collagen xvii a shared antigen in neurodermatological interactions |
| url | http://dx.doi.org/10.1155/2013/240570 |
| work_keys_str_mv | AT allanseppanen collagenxviiasharedantigeninneurodermatologicalinteractions |