Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation
Objective. Inflammation and pain are involved in the pathophysiology of various clinical conditions. This investigation aims to probe the analgesic and anti-inflammatory activity of Maltoamide F. Methods. The possible toxicity of Maltoamide F was evaluated by an acute toxicity test. To assess the an...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2021/4919391 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549659086684160 |
|---|---|
| author | Zhuocheng Li Lei Zhang Zhichao Zhao |
| author_facet | Zhuocheng Li Lei Zhang Zhichao Zhao |
| author_sort | Zhuocheng Li |
| collection | DOAJ |
| description | Objective. Inflammation and pain are involved in the pathophysiology of various clinical conditions. This investigation aims to probe the analgesic and anti-inflammatory activity of Maltoamide F. Methods. The possible toxicity of Maltoamide F was evaluated by an acute toxicity test. To assess the anti-inflammatory and antinociceptive effects of Maltoamide F on rats, the models of carrageenan-caused paw edema, xylene-induced ear edema, arachidonic-acid- (AA-) induced ear edema, formalin-caused plantar edema, and cotton-pellet-induced granuloma were established. Levels of TNF-α, PGE-2, and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA). Results. Maltoamide F was safe at oral doses of 1–10 mg/kg for rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) notably reduced carrageenan-induced edema percentage of paws in rats and decreased levels of PGE-2, IL-6, and TNF-α in homogenates of foot tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-α in foot tissues of formalin-induced rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) repressed AA-induced increase of ear thickness in rats and reduced levels of PGE-2, IL-6, and TNF-α in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced xylene-induced weight of ear edema in rats and reduced levels of PGE-2, IL-6, and TNF-α in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-α in homogenates of cotton ball granuloma of cotton-pellet-induced rats. Conclusions. Maltoamide F possessed anti-inflammatory and analgesic activity in inflammatory models of rats. |
| format | Article |
| id | doaj-art-6e8eb891569b46559a8ae48d8a29d9e0 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-6e8eb891569b46559a8ae48d8a29d9e02025-02-03T06:10:47ZengWileyPain Research and Management1203-67651918-15232021-01-01202110.1155/2021/49193914919391Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of InflammationZhuocheng Li0Lei Zhang1Zhichao Zhao2Department of Anesthesiology, Heilongjiang Provincial Hospital, No. 82 Zhongshan Road, Xiangfang District, Harbin City, Heilongjiang Province 150036, ChinaDepartment of Anesthesiology, Harbin Chest Hospital, No. 417 Xianfeng Road, Daowai District, Harbin City, Heilongjiang Province 150026, ChinaOperation Room, Heilongjiang Provincial Hospital, No. 82 Zhongshan Road, Xiangfang District, Harbin City, Heilongjiang Province 150036, ChinaObjective. Inflammation and pain are involved in the pathophysiology of various clinical conditions. This investigation aims to probe the analgesic and anti-inflammatory activity of Maltoamide F. Methods. The possible toxicity of Maltoamide F was evaluated by an acute toxicity test. To assess the anti-inflammatory and antinociceptive effects of Maltoamide F on rats, the models of carrageenan-caused paw edema, xylene-induced ear edema, arachidonic-acid- (AA-) induced ear edema, formalin-caused plantar edema, and cotton-pellet-induced granuloma were established. Levels of TNF-α, PGE-2, and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA). Results. Maltoamide F was safe at oral doses of 1–10 mg/kg for rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) notably reduced carrageenan-induced edema percentage of paws in rats and decreased levels of PGE-2, IL-6, and TNF-α in homogenates of foot tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-α in foot tissues of formalin-induced rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) repressed AA-induced increase of ear thickness in rats and reduced levels of PGE-2, IL-6, and TNF-α in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced xylene-induced weight of ear edema in rats and reduced levels of PGE-2, IL-6, and TNF-α in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-α in homogenates of cotton ball granuloma of cotton-pellet-induced rats. Conclusions. Maltoamide F possessed anti-inflammatory and analgesic activity in inflammatory models of rats.http://dx.doi.org/10.1155/2021/4919391 |
| spellingShingle | Zhuocheng Li Lei Zhang Zhichao Zhao Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation Pain Research and Management |
| title | Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation |
| title_full | Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation |
| title_fullStr | Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation |
| title_full_unstemmed | Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation |
| title_short | Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation |
| title_sort | malyngamide f possesses anti inflammatory and antinociceptive activity in rat models of inflammation |
| url | http://dx.doi.org/10.1155/2021/4919391 |
| work_keys_str_mv | AT zhuochengli malyngamidefpossessesantiinflammatoryandantinociceptiveactivityinratmodelsofinflammation AT leizhang malyngamidefpossessesantiinflammatoryandantinociceptiveactivityinratmodelsofinflammation AT zhichaozhao malyngamidefpossessesantiinflammatoryandantinociceptiveactivityinratmodelsofinflammation |