Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.

Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.

Melanin protects the skin and eyes from the harmful effects of UV irradiation, protects neural cells from toxic insults, and is required for sound conduction in the inner ear. Aberrant regulation of melanogenesis underlies skin disorders (melasma and vitiligo), neurologic disorders (Parkinson's...

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Bibliographic Details
Main Authors: Anand K Ganesan, Hsiang Ho, Brian Bodemann, Sean Petersen, Jayavani Aruri, Shiney Koshy, Zachary Richardson, Lu Q Le, Tatiana Krasieva, Michael G Roth, Pat Farmer, Michael A White
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-12-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000298&type=printable
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