Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) Complexes
To synthesize new symmetrical macroacyclic Schiff base ligands (L1 and L2), polyamine (A) was condensed with 2-formylpyridine and salicylaldehyde. Furthermore, Ni(ClO4)2.6H2O and Zn(ClO4)2.6H2O in methanol were reacted with the ligands to prepare corresponding metal complexes. The cytotoxicity of th...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2023/6921116 |
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| author | Hassan Keypour Mohammad Taher Rezaei Saadat Hajari Mahdi Jamshidi Seyed Hamed Moazzami Farida |
| author_facet | Hassan Keypour Mohammad Taher Rezaei Saadat Hajari Mahdi Jamshidi Seyed Hamed Moazzami Farida |
| author_sort | Hassan Keypour |
| collection | DOAJ |
| description | To synthesize new symmetrical macroacyclic Schiff base ligands (L1 and L2), polyamine (A) was condensed with 2-formylpyridine and salicylaldehyde. Furthermore, Ni(ClO4)2.6H2O and Zn(ClO4)2.6H2O in methanol were reacted with the ligands to prepare corresponding metal complexes. The cytotoxicity of the synthesized complexes against MCF-7 and A549 adenocarcinoma cells was evaluated, where Zn-complexes displayed greater cytotoxic effects than Ni-complexes. Conductivity measurements, ESI-MS, UV-Vis, molar conductivity, IR, 1H, and 13C NMR spectra were used to characterize the products. Furthermore, molecular docking was performed to assess the biological activity of the complexes, and it was observed that Zn-complexes exhibited the highest inhibition effect against cytotoxic receptors. |
| format | Article |
| id | doaj-art-6e8b993b53794805b60caf785bebd000 |
| institution | Kabale University |
| issn | 2090-9071 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-6e8b993b53794805b60caf785bebd0002025-02-03T06:45:35ZengWileyJournal of Chemistry2090-90712023-01-01202310.1155/2023/6921116Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) ComplexesHassan Keypour0Mohammad Taher Rezaei1Saadat Hajari2Mahdi Jamshidi3Seyed Hamed Moazzami Farida4Faculty of ChemistryFaculty of ChemistryFaculty of ChemistryFaculty of ChemistryDepartment of BiologyTo synthesize new symmetrical macroacyclic Schiff base ligands (L1 and L2), polyamine (A) was condensed with 2-formylpyridine and salicylaldehyde. Furthermore, Ni(ClO4)2.6H2O and Zn(ClO4)2.6H2O in methanol were reacted with the ligands to prepare corresponding metal complexes. The cytotoxicity of the synthesized complexes against MCF-7 and A549 adenocarcinoma cells was evaluated, where Zn-complexes displayed greater cytotoxic effects than Ni-complexes. Conductivity measurements, ESI-MS, UV-Vis, molar conductivity, IR, 1H, and 13C NMR spectra were used to characterize the products. Furthermore, molecular docking was performed to assess the biological activity of the complexes, and it was observed that Zn-complexes exhibited the highest inhibition effect against cytotoxic receptors.http://dx.doi.org/10.1155/2023/6921116 |
| spellingShingle | Hassan Keypour Mohammad Taher Rezaei Saadat Hajari Mahdi Jamshidi Seyed Hamed Moazzami Farida Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) Complexes Journal of Chemistry |
| title | Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) Complexes |
| title_full | Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) Complexes |
| title_fullStr | Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) Complexes |
| title_full_unstemmed | Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) Complexes |
| title_short | Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) Complexes |
| title_sort | synthesis and evaluation of cytotoxicity and molecular docking of new symmetrical macroacyclic schiff base ligands and their ni ii and zn ii complexes |
| url | http://dx.doi.org/10.1155/2023/6921116 |
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