Clinical Thyrotoxicosis Resulting from Liothyronine Augmentation of Antidepressant Therapy in an Adolescent
Background/Objective. Thyrotoxicosis, a condition resulting from excessive peripheral thyroid hormone, is typically accompanied by thyroid function tests demonstrating a high free thyroxine (free T4) with appropriate suppression of thyroid-stimulating hormone (TSH). Case report. We describe a 17-yea...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2022/2270202 |
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| _version_ | 1832553472468189184 |
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| author | Benjamin A. Pallant Claire E. Moore Lisa Swartz Topor |
| author_facet | Benjamin A. Pallant Claire E. Moore Lisa Swartz Topor |
| author_sort | Benjamin A. Pallant |
| collection | DOAJ |
| description | Background/Objective. Thyrotoxicosis, a condition resulting from excessive peripheral thyroid hormone, is typically accompanied by thyroid function tests demonstrating a high free thyroxine (free T4) with appropriate suppression of thyroid-stimulating hormone (TSH). Case report. We describe a 17-year-old female presenting with symptoms of thyrotoxicosis along with suppressed TSH and low free T4, a laboratory pattern concerning for central hypothyroidism. Further history revealed that she was prescribed liothyronine as an adjunct therapy for depression. Discussion. Due to the short half-life of liothyronine, clinical signs and symptoms of thyrotoxicosis may develop before detection by interval lab monitoring. Conclusion. This case highlights the need for close monitoring and caution when treating adolescents with liothyronine and the importance of interpreting atypical laboratory findings within clinical context. |
| format | Article |
| id | doaj-art-6e87ce8a56cc4a8a9645194bd393fc2d |
| institution | Kabale University |
| issn | 2090-6838 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-6e87ce8a56cc4a8a9645194bd393fc2d2025-02-03T05:53:50ZengWileyCase Reports in Psychiatry2090-68382022-01-01202210.1155/2022/2270202Clinical Thyrotoxicosis Resulting from Liothyronine Augmentation of Antidepressant Therapy in an AdolescentBenjamin A. Pallant0Claire E. Moore1Lisa Swartz Topor2Warren Alpert Medical School of Brown UniversityDepartment of PediatricsDepartment of PediatricsBackground/Objective. Thyrotoxicosis, a condition resulting from excessive peripheral thyroid hormone, is typically accompanied by thyroid function tests demonstrating a high free thyroxine (free T4) with appropriate suppression of thyroid-stimulating hormone (TSH). Case report. We describe a 17-year-old female presenting with symptoms of thyrotoxicosis along with suppressed TSH and low free T4, a laboratory pattern concerning for central hypothyroidism. Further history revealed that she was prescribed liothyronine as an adjunct therapy for depression. Discussion. Due to the short half-life of liothyronine, clinical signs and symptoms of thyrotoxicosis may develop before detection by interval lab monitoring. Conclusion. This case highlights the need for close monitoring and caution when treating adolescents with liothyronine and the importance of interpreting atypical laboratory findings within clinical context.http://dx.doi.org/10.1155/2022/2270202 |
| spellingShingle | Benjamin A. Pallant Claire E. Moore Lisa Swartz Topor Clinical Thyrotoxicosis Resulting from Liothyronine Augmentation of Antidepressant Therapy in an Adolescent Case Reports in Psychiatry |
| title | Clinical Thyrotoxicosis Resulting from Liothyronine Augmentation of Antidepressant Therapy in an Adolescent |
| title_full | Clinical Thyrotoxicosis Resulting from Liothyronine Augmentation of Antidepressant Therapy in an Adolescent |
| title_fullStr | Clinical Thyrotoxicosis Resulting from Liothyronine Augmentation of Antidepressant Therapy in an Adolescent |
| title_full_unstemmed | Clinical Thyrotoxicosis Resulting from Liothyronine Augmentation of Antidepressant Therapy in an Adolescent |
| title_short | Clinical Thyrotoxicosis Resulting from Liothyronine Augmentation of Antidepressant Therapy in an Adolescent |
| title_sort | clinical thyrotoxicosis resulting from liothyronine augmentation of antidepressant therapy in an adolescent |
| url | http://dx.doi.org/10.1155/2022/2270202 |
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