Competitive binding between DDX21 and SIRT7 enhances NAT10-mediated ac4C modification to promote colorectal cancer metastasis and angiogenesis– DDX21 promotes colorectal cancer metastasis

Competitive binding between DDX21 and SIRT7 enhances NAT10-mediated ac4C modification to promote colorectal cancer metastasis and angiogenesis– DDX21 promotes colorectal cancer metastasis

Abstract DExD- box helicase 21 (DDX21) is overexpressed in colorectal cancer (CRC) and is positively correlated with poor prognosis and the malignant phenotype of CRC. Functional characterization indicated that DDX21 promotes CRC metastasis and angiogenesis both in vitro and in vivo. N-acetyltransfe...

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Main Authors: Angxi Song, Bowen Liu, Wenjing Li, Bingyuan Chen, Pengkun Gui, Hao Zhang, Can Zhu, Yixin Xu, Tao Jiang, Jun Song
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07656-3
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