Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia
The development of acute lymphoblastic leukemia in an existing myeloproliferative neoplasm is rare with historical cases unable to differentiate between concomitant malignancies or leukemic transformation. Molecular studies of coexisting JAK2 V617F-positive myeloproliferative neoplasms and mature B...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/6545861 |
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| _version_ | 1832551883365941248 |
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| author | Stephen E. Langabeer Karl Haslam David O’Brien Johanna Kelly Claire Andrews Ciara Ryan Richard Flavin Patrick J. Hayden Christopher L. Bacon |
| author_facet | Stephen E. Langabeer Karl Haslam David O’Brien Johanna Kelly Claire Andrews Ciara Ryan Richard Flavin Patrick J. Hayden Christopher L. Bacon |
| author_sort | Stephen E. Langabeer |
| collection | DOAJ |
| description | The development of acute lymphoblastic leukemia in an existing myeloproliferative neoplasm is rare with historical cases unable to differentiate between concomitant malignancies or leukemic transformation. Molecular studies of coexisting JAK2 V617F-positive myeloproliferative neoplasms and mature B cell malignancies indicate distinct disease entities arising in myeloid and lymphoid committed hematopoietic progenitor cells, respectively. Mutations of CALR in essential thrombocythemia appear to be associated with a distinct phenotype and a lower risk of thrombosis yet their impact on disease progression is less well defined. The as yet undescribed scenario of pro-B cell acute lymphoblastic leukemia arising in CALR mutated essential thrombocythemia is presented. Intensive treatment for the leukemia allowed for expansion of the original CALR mutated clone. Whether CALR mutations in myeloproliferative neoplasms predispose to the acquisition of additional malignancies, particularly lymphoproliferative disorders, is not yet known. |
| format | Article |
| id | doaj-art-6e7474b03b2c455185d6e7c45669da52 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-6e7474b03b2c455185d6e7c45669da522025-02-03T06:00:18ZengWileyCase Reports in Hematology2090-65602090-65792016-01-01201610.1155/2016/65458616545861Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential ThrombocythemiaStephen E. Langabeer0Karl Haslam1David O’Brien2Johanna Kelly3Claire Andrews4Ciara Ryan5Richard Flavin6Patrick J. Hayden7Christopher L. Bacon8Cancer Molecular Diagnostics, St. James’s Hospital, Dublin 8, IrelandCancer Molecular Diagnostics, St. James’s Hospital, Dublin 8, IrelandDepartment of Haematology, St. James’s Hospital, Dublin 8, IrelandDepartment of Clinical Genetics, Our Lady’s Children’s Hospital, Dublin 12, IrelandDepartment of Haematology, St. James’s Hospital, Dublin 8, IrelandDepartment of Histopathology, St. James’s Hospital, Dublin 8, IrelandDepartment of Histopathology, St. James’s Hospital, Dublin 8, IrelandDepartment of Haematology, St. James’s Hospital, Dublin 8, IrelandDepartment of Haematology, St. James’s Hospital, Dublin 8, IrelandThe development of acute lymphoblastic leukemia in an existing myeloproliferative neoplasm is rare with historical cases unable to differentiate between concomitant malignancies or leukemic transformation. Molecular studies of coexisting JAK2 V617F-positive myeloproliferative neoplasms and mature B cell malignancies indicate distinct disease entities arising in myeloid and lymphoid committed hematopoietic progenitor cells, respectively. Mutations of CALR in essential thrombocythemia appear to be associated with a distinct phenotype and a lower risk of thrombosis yet their impact on disease progression is less well defined. The as yet undescribed scenario of pro-B cell acute lymphoblastic leukemia arising in CALR mutated essential thrombocythemia is presented. Intensive treatment for the leukemia allowed for expansion of the original CALR mutated clone. Whether CALR mutations in myeloproliferative neoplasms predispose to the acquisition of additional malignancies, particularly lymphoproliferative disorders, is not yet known.http://dx.doi.org/10.1155/2016/6545861 |
| spellingShingle | Stephen E. Langabeer Karl Haslam David O’Brien Johanna Kelly Claire Andrews Ciara Ryan Richard Flavin Patrick J. Hayden Christopher L. Bacon Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia Case Reports in Hematology |
| title | Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia |
| title_full | Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia |
| title_fullStr | Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia |
| title_full_unstemmed | Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia |
| title_short | Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia |
| title_sort | acute lymphoblastic leukemia arising in calr mutated essential thrombocythemia |
| url | http://dx.doi.org/10.1155/2016/6545861 |
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