Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness
Aim. GCK-MODY is an autosomal dominant form of diabetes caused by heterozygous mutations in the glucokinase gene leading to a lifelong mild hyperglycemia. The risk of macrovascular complications is considered low, but studies are limited. We, therefore, investigated the carotid intima-media thicknes...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/718254 |
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| author | Stepanka Pruhova Petra Dusatkova Pavel J. Kraml Michal Kulich Zdena Prochazkova Jan Broz Jaroslav Zikmund Ondrej Cinek Michal Andel Oluf Pedersen Torben Hansen Jan Lebl |
| author_facet | Stepanka Pruhova Petra Dusatkova Pavel J. Kraml Michal Kulich Zdena Prochazkova Jan Broz Jaroslav Zikmund Ondrej Cinek Michal Andel Oluf Pedersen Torben Hansen Jan Lebl |
| author_sort | Stepanka Pruhova |
| collection | DOAJ |
| description | Aim. GCK-MODY is an autosomal dominant form of diabetes caused by heterozygous mutations in the glucokinase gene leading to a lifelong mild hyperglycemia. The risk of macrovascular complications is considered low, but studies are limited. We, therefore, investigated the carotid intima-media thickness (CIMT) as an indicator of macrovascular complications in a group of patients with GCK-MODY. Methods. Twenty-seven GCK mutation carriers and 24 controls recruited among their first-degree relatives were compared, all aging over 35 years. The CIMT was tested using a high-resolution B-mode carotid ultrasonography. Medical history, anthropometry, and biochemical blood workup were obtained. Results. The mean CIMT was 0.707 ± 0.215 mm (mean ± SD) in GCK mutation carriers and 0.690 ± 0.180 mm in control individuals. When adjusted for age, gender, and family status, the estimated mean difference in CIMT between the two groups increased to 0.049 mm (P=0.19). No difference was detected for other characteristics, with the exception of fasting blood glucose (GCK-MODY 7.6 mmol/L ± 1.2 (136.4 mg/dL); controls 5.3 mmol/L ± 0.3 (95.4 mg/dL); P<0.0001) and glycated hemoglobin HbA1c (GCK-MODY 6.9% ± 1.0%, 52 mmol/mol ± 10; controls 5.7% ± 0.4%, 39 mmol/mol ± 3; P<0.0001). The frequency of myocardial infarction and ischemic stroke did not differ between groups. Conclusion. Our data indicate that the persistent hyperglycemia in GCK-MODY is associated with a low risk of developing diabetic macrovascular complications. |
| format | Article |
| id | doaj-art-6e64715ebc0d4de5a9a37b9e9200fbca |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6e64715ebc0d4de5a9a37b9e9200fbca2025-02-03T01:23:04ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/718254718254Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media ThicknessStepanka Pruhova0Petra Dusatkova1Pavel J. Kraml2Michal Kulich3Zdena Prochazkova4Jan Broz5Jaroslav Zikmund6Ondrej Cinek7Michal Andel8Oluf Pedersen9Torben Hansen10Jan Lebl11Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, 150 06 Prague, Czech RepublicDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, 150 06 Prague, Czech Republic2nd Department of Internal Medicine, 3rd Faculty of Medicine, Charles University in Prague and University Hospital Kralovské Vinohrady, 100 81 Prague, Czech RepublicDepartment of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University in Prague, 186 75 Prague, Czech Republic2nd Department of Internal Medicine, 3rd Faculty of Medicine, Charles University in Prague and University Hospital Kralovské Vinohrady, 100 81 Prague, Czech RepublicDepartment of Internal Medicine, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, 150 06 Prague, Czech RepublicDepartment of Pediatrics, 3rd Faculty of Medicine, Charles University in Prague and University Hospital Kralovské Vinohrady, 100 81 Prague, Czech RepublicDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, 150 06 Prague, Czech Republic2nd Department of Internal Medicine, 3rd Faculty of Medicine, Charles University in Prague and University Hospital Kralovské Vinohrady, 100 81 Prague, Czech RepublicHagedorn Research Institute, 2820 Gentofte, DenmarkThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, 150 06 Prague, Czech RepublicAim. GCK-MODY is an autosomal dominant form of diabetes caused by heterozygous mutations in the glucokinase gene leading to a lifelong mild hyperglycemia. The risk of macrovascular complications is considered low, but studies are limited. We, therefore, investigated the carotid intima-media thickness (CIMT) as an indicator of macrovascular complications in a group of patients with GCK-MODY. Methods. Twenty-seven GCK mutation carriers and 24 controls recruited among their first-degree relatives were compared, all aging over 35 years. The CIMT was tested using a high-resolution B-mode carotid ultrasonography. Medical history, anthropometry, and biochemical blood workup were obtained. Results. The mean CIMT was 0.707 ± 0.215 mm (mean ± SD) in GCK mutation carriers and 0.690 ± 0.180 mm in control individuals. When adjusted for age, gender, and family status, the estimated mean difference in CIMT between the two groups increased to 0.049 mm (P=0.19). No difference was detected for other characteristics, with the exception of fasting blood glucose (GCK-MODY 7.6 mmol/L ± 1.2 (136.4 mg/dL); controls 5.3 mmol/L ± 0.3 (95.4 mg/dL); P<0.0001) and glycated hemoglobin HbA1c (GCK-MODY 6.9% ± 1.0%, 52 mmol/mol ± 10; controls 5.7% ± 0.4%, 39 mmol/mol ± 3; P<0.0001). The frequency of myocardial infarction and ischemic stroke did not differ between groups. Conclusion. Our data indicate that the persistent hyperglycemia in GCK-MODY is associated with a low risk of developing diabetic macrovascular complications.http://dx.doi.org/10.1155/2013/718254 |
| spellingShingle | Stepanka Pruhova Petra Dusatkova Pavel J. Kraml Michal Kulich Zdena Prochazkova Jan Broz Jaroslav Zikmund Ondrej Cinek Michal Andel Oluf Pedersen Torben Hansen Jan Lebl Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness International Journal of Endocrinology |
| title | Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness |
| title_full | Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness |
| title_fullStr | Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness |
| title_full_unstemmed | Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness |
| title_short | Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness |
| title_sort | chronic mild hyperglycemia in gck mody patients does not increase carotid intima media thickness |
| url | http://dx.doi.org/10.1155/2013/718254 |
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