Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature
Systemic sclerosis (SSc) is an uncommon rheumatic disease in which the underlying main histopathologic feature is a thickening of the skin due to excessive accumulation of collagen in the extracellular tissue. Fibrogenesis, chronic inflammation, and ulceration may eventually promote skin neoplasms....
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/6628671 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550144624558080 |
|---|---|
| author | Firdevs Ulutaş Erdem Çomut Veli Çobankara |
| author_facet | Firdevs Ulutaş Erdem Çomut Veli Çobankara |
| author_sort | Firdevs Ulutaş |
| collection | DOAJ |
| description | Systemic sclerosis (SSc) is an uncommon rheumatic disease in which the underlying main histopathologic feature is a thickening of the skin due to excessive accumulation of collagen in the extracellular tissue. Fibrogenesis, chronic inflammation, and ulceration may eventually promote skin neoplasms. Although nonmelanoma skin cancer (NMSC) is the most frequent type, there have been restricted case reports and case series with skin cancers in SSc patients in the literature. Herein, we describe a 78-year-old woman diagnosed with diffuse cutaneous systemic sclerosis thirteen years ago and associated nonspecific interstitial pneumonia that was successfully treated with high cumulative doses of cyclophosphamide. She developed basal cell carcinoma and squamous cell carcinoma of the skin in the follow-up. She is still on rituximab treatment with stable interstitial lung disease as indicated by pulmonary function tests and high-resolution chest computed tomography. To our knowledge and a literature search, this is the first reported patient with SSc with two types of skin cancer. In this review, we also aimed to emphasize the relationship between SSc and skin cancer, and possible risk factors for SSc-related skin cancer. |
| format | Article |
| id | doaj-art-6e44955e6468430aaa41257521e6232e |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-6e44955e6468430aaa41257521e6232e2025-02-03T06:07:40ZengWileyCase Reports in Oncological Medicine2090-67062090-67142021-01-01202110.1155/2021/66286716628671Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the LiteratureFirdevs Ulutaş0Erdem Çomut1Veli Çobankara2Division of Rheumatology, Department of Internal Medicine, Pamukkale University Faculty of Medicine, Denizli, TurkeyDepartment of Pathology, Pamukkale University Faculty of Medicine, Denizli, TurkeyDivision of Rheumatology, Department of Internal Medicine, Pamukkale University Faculty of Medicine, Denizli, TurkeySystemic sclerosis (SSc) is an uncommon rheumatic disease in which the underlying main histopathologic feature is a thickening of the skin due to excessive accumulation of collagen in the extracellular tissue. Fibrogenesis, chronic inflammation, and ulceration may eventually promote skin neoplasms. Although nonmelanoma skin cancer (NMSC) is the most frequent type, there have been restricted case reports and case series with skin cancers in SSc patients in the literature. Herein, we describe a 78-year-old woman diagnosed with diffuse cutaneous systemic sclerosis thirteen years ago and associated nonspecific interstitial pneumonia that was successfully treated with high cumulative doses of cyclophosphamide. She developed basal cell carcinoma and squamous cell carcinoma of the skin in the follow-up. She is still on rituximab treatment with stable interstitial lung disease as indicated by pulmonary function tests and high-resolution chest computed tomography. To our knowledge and a literature search, this is the first reported patient with SSc with two types of skin cancer. In this review, we also aimed to emphasize the relationship between SSc and skin cancer, and possible risk factors for SSc-related skin cancer.http://dx.doi.org/10.1155/2021/6628671 |
| spellingShingle | Firdevs Ulutaş Erdem Çomut Veli Çobankara Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature Case Reports in Oncological Medicine |
| title | Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature |
| title_full | Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature |
| title_fullStr | Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature |
| title_full_unstemmed | Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature |
| title_short | Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature |
| title_sort | development of two types of skin cancer in a patient with systemic sclerosis a case report and overview of the literature |
| url | http://dx.doi.org/10.1155/2021/6628671 |
| work_keys_str_mv | AT firdevsulutas developmentoftwotypesofskincancerinapatientwithsystemicsclerosisacasereportandoverviewoftheliterature AT erdemcomut developmentoftwotypesofskincancerinapatientwithsystemicsclerosisacasereportandoverviewoftheliterature AT velicobankara developmentoftwotypesofskincancerinapatientwithsystemicsclerosisacasereportandoverviewoftheliterature |