Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer Immunotherapy
Dendritic cells (DC) represent a diverse group of professional antigen-presenting cells that serve to link the innate and adaptive immune systems. Their capacity to initiate a robust and antigen-specific immune response has made them the ideal candidates for cancer immunotherapies. To date, the clin...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/624123 |
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| author | Valerie R. Yanofsky Hiroshi Mitsui Diane Felsen John A. Carucci |
| author_facet | Valerie R. Yanofsky Hiroshi Mitsui Diane Felsen John A. Carucci |
| author_sort | Valerie R. Yanofsky |
| collection | DOAJ |
| description | Dendritic cells (DC) represent a diverse group of professional antigen-presenting cells that serve to link the innate and adaptive immune systems. Their capacity to initiate a robust and antigen-specific immune response has made them the ideal candidates for cancer immunotherapies. To date, the clinical impact of DC immunotherapy has been limited, which may, in part, be explained by the complex nature of DC biology. Multiple distinct subsets of DCs have been identified in the skin, where they can be broadly subcategorized into epidermal Langerhans cells (LC), myeloid-derived dermal dendritic cells (mDC) and plasmacytoid dendritic cells (pDC). Each subset is functionally unique and may activate alternate branches of the immune system. This may be relevant for the treatment of squamous cell carcinoma, where we have shown that the tumor microenvironment may preferentially suppress the activity of mDCs, while LCs remain potent stimulators of immunity. Here, we provide an in depth analysis of DC biology, with a particular focus on skin DCs and their role in cutaneous carcinoma. We further explore the current approaches to DC immunotherapy and provide evidence for the targeting of LCs as a promising new strategy in the treatment of skin cancer. |
| format | Article |
| id | doaj-art-6e36bd317cb545acb51cf36ef7fad91c |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-6e36bd317cb545acb51cf36ef7fad91c2025-08-20T03:33:54ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/624123624123Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer ImmunotherapyValerie R. Yanofsky0Hiroshi Mitsui1Diane Felsen2John A. Carucci3Department of Dermatology, NYU Langone Medical Center, New York, NY 10016, USALab for Investigative Dermatology, Rockefeller University, New York, NY 10065, USAInstitute for Pediatric Urology, Weill Cornell Medical Center, New York, NY 10021, USADepartment of Dermatology, NYU Langone Medical Center, New York, NY 10016, USADendritic cells (DC) represent a diverse group of professional antigen-presenting cells that serve to link the innate and adaptive immune systems. Their capacity to initiate a robust and antigen-specific immune response has made them the ideal candidates for cancer immunotherapies. To date, the clinical impact of DC immunotherapy has been limited, which may, in part, be explained by the complex nature of DC biology. Multiple distinct subsets of DCs have been identified in the skin, where they can be broadly subcategorized into epidermal Langerhans cells (LC), myeloid-derived dermal dendritic cells (mDC) and plasmacytoid dendritic cells (pDC). Each subset is functionally unique and may activate alternate branches of the immune system. This may be relevant for the treatment of squamous cell carcinoma, where we have shown that the tumor microenvironment may preferentially suppress the activity of mDCs, while LCs remain potent stimulators of immunity. Here, we provide an in depth analysis of DC biology, with a particular focus on skin DCs and their role in cutaneous carcinoma. We further explore the current approaches to DC immunotherapy and provide evidence for the targeting of LCs as a promising new strategy in the treatment of skin cancer.http://dx.doi.org/10.1155/2013/624123 |
| spellingShingle | Valerie R. Yanofsky Hiroshi Mitsui Diane Felsen John A. Carucci Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer Immunotherapy Clinical and Developmental Immunology |
| title | Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer Immunotherapy |
| title_full | Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer Immunotherapy |
| title_fullStr | Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer Immunotherapy |
| title_full_unstemmed | Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer Immunotherapy |
| title_short | Understanding Dendritic Cells and Their Role in Cutaneous Carcinoma and Cancer Immunotherapy |
| title_sort | understanding dendritic cells and their role in cutaneous carcinoma and cancer immunotherapy |
| url | http://dx.doi.org/10.1155/2013/624123 |
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