Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis
The present study was undertaken to find out the ability of black tea extract (BTE) as a suitable alternative of adjunct for calcium supplementation in treating an ovariectomized rat model of early osteoporosis. Female Wistar rats weighing 140–150 g were divided into four groups consisting of six an...
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| Format: | Article |
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Wiley
2013-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2013/760586 |
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| author | Asankur Sekhar Das Maitrayee Banerjee Dolan Das Sandip Mukherjee Chandan Mitra |
| author_facet | Asankur Sekhar Das Maitrayee Banerjee Dolan Das Sandip Mukherjee Chandan Mitra |
| author_sort | Asankur Sekhar Das |
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| description | The present study was undertaken to find out the ability of black tea extract (BTE) as a suitable alternative of adjunct for calcium supplementation in treating an ovariectomized rat model of early osteoporosis. Female Wistar rats weighing 140–150 g were divided into four groups consisting of six animals in each group: (A) sham-operated control; (B) bilaterally ovariectomized; (C) bilaterally ovariectomized + BTE; (D) bilaterally ovariectomized + 17β-estradiol. Results suggest that BTE could promote intestinal absorption of calcium significantly (P<0.01 for duodenum and ileum; and P<0.05 for jejunum). This was found associated with enhanced activities of two relevant intestinal mucosal enzymes alkaline phosphatase (P<0.01 for duodenum, jejunum, and ileum) and Ca2+ activated ATPase (P<0.01 for duodenum, jejunum, and ileum). Such BTE-mediated promotion of calcium absorption was coupled with increase in serum estrogen titer (P<0.01) and recovery of all urinary, bone, and serum osteoporotic marker parameters, including bone histological features. Serum parathyroid hormone level, however, was not altered in these animals (P>0.05). A comparative study with 17β-estradiol, a well-known adjunct for calcium supplementation, indicated that efficacy of BTE in maintaining skeletal health is close to that of 17β-estradiol. This study suggests that simultaneous use of BTE is promising as a prospective candidate for adjunctive therapies for calcium supplementation in the early stage of menopausal bone changes. |
| format | Article |
| id | doaj-art-6e2f31d2cfa645fb9634c6551638b6fb |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | Journal of Osteoporosis |
| spelling | doaj-art-6e2f31d2cfa645fb9634c6551638b6fb2025-02-03T01:11:05ZengWileyJournal of Osteoporosis2090-80592042-00642013-01-01201310.1155/2013/760586760586Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of OsteoporosisAsankur Sekhar Das0Maitrayee Banerjee1Dolan Das2Sandip Mukherjee3Chandan Mitra4Pre-Clinical Physiology Laboratory, Tripura Institute of Paramedical Sciences, Hapania, Amtali, Tripura 799 130, IndiaFormerly Department of Physiology, Presidency College, Kolkata, West Bengal, IndiaFormerly Department of Physiology, Presidency College, Kolkata, West Bengal, IndiaFormerly Department of Physiology, Presidency College, Kolkata, West Bengal, IndiaPre-Clinical Physiology Laboratory, Tripura Institute of Paramedical Sciences, Hapania, Amtali, Tripura 799 130, IndiaThe present study was undertaken to find out the ability of black tea extract (BTE) as a suitable alternative of adjunct for calcium supplementation in treating an ovariectomized rat model of early osteoporosis. Female Wistar rats weighing 140–150 g were divided into four groups consisting of six animals in each group: (A) sham-operated control; (B) bilaterally ovariectomized; (C) bilaterally ovariectomized + BTE; (D) bilaterally ovariectomized + 17β-estradiol. Results suggest that BTE could promote intestinal absorption of calcium significantly (P<0.01 for duodenum and ileum; and P<0.05 for jejunum). This was found associated with enhanced activities of two relevant intestinal mucosal enzymes alkaline phosphatase (P<0.01 for duodenum, jejunum, and ileum) and Ca2+ activated ATPase (P<0.01 for duodenum, jejunum, and ileum). Such BTE-mediated promotion of calcium absorption was coupled with increase in serum estrogen titer (P<0.01) and recovery of all urinary, bone, and serum osteoporotic marker parameters, including bone histological features. Serum parathyroid hormone level, however, was not altered in these animals (P>0.05). A comparative study with 17β-estradiol, a well-known adjunct for calcium supplementation, indicated that efficacy of BTE in maintaining skeletal health is close to that of 17β-estradiol. This study suggests that simultaneous use of BTE is promising as a prospective candidate for adjunctive therapies for calcium supplementation in the early stage of menopausal bone changes.http://dx.doi.org/10.1155/2013/760586 |
| spellingShingle | Asankur Sekhar Das Maitrayee Banerjee Dolan Das Sandip Mukherjee Chandan Mitra Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis Journal of Osteoporosis |
| title | Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis |
| title_full | Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis |
| title_fullStr | Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis |
| title_full_unstemmed | Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis |
| title_short | Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis |
| title_sort | black tea may be a prospective adjunct for calcium supplementation to prevent early menopausal bone loss in a rat model of osteoporosis |
| url | http://dx.doi.org/10.1155/2013/760586 |
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