Understanding glioblastoma at the single-cell level: Recent advances and future challenges.
Glioblastoma, the most aggressive and prevalent form of primary brain tumor, is characterized by rapid growth, diffuse infiltration, and resistance to therapies. Intrinsic heterogeneity and cellular plasticity contribute to its rapid progression under therapy; therefore, there is a need to fully und...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-05-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002640 |
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| author | Yahaya A Yabo Dieter Henrik Heiland |
| author_facet | Yahaya A Yabo Dieter Henrik Heiland |
| author_sort | Yahaya A Yabo |
| collection | DOAJ |
| description | Glioblastoma, the most aggressive and prevalent form of primary brain tumor, is characterized by rapid growth, diffuse infiltration, and resistance to therapies. Intrinsic heterogeneity and cellular plasticity contribute to its rapid progression under therapy; therefore, there is a need to fully understand these tumors at a single-cell level. Over the past decade, single-cell transcriptomics has enabled the molecular characterization of individual cells within glioblastomas, providing previously unattainable insights into the genetic and molecular features that drive tumorigenesis, disease progression, and therapy resistance. However, despite advances in single-cell technologies, challenges such as high costs, complex data analysis and interpretation, and difficulties in translating findings into clinical practice persist. As single-cell technologies are developed further, more insights into the cellular and molecular heterogeneity of glioblastomas are expected, which will help guide the development of personalized and effective therapies, thereby improving prognosis and quality of life for patients. |
| format | Article |
| id | doaj-art-6e25a2af75634933afc145003ed5b73c |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-6e25a2af75634933afc145003ed5b73c2025-01-21T05:30:41ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852024-05-01225e300264010.1371/journal.pbio.3002640Understanding glioblastoma at the single-cell level: Recent advances and future challenges.Yahaya A YaboDieter Henrik HeilandGlioblastoma, the most aggressive and prevalent form of primary brain tumor, is characterized by rapid growth, diffuse infiltration, and resistance to therapies. Intrinsic heterogeneity and cellular plasticity contribute to its rapid progression under therapy; therefore, there is a need to fully understand these tumors at a single-cell level. Over the past decade, single-cell transcriptomics has enabled the molecular characterization of individual cells within glioblastomas, providing previously unattainable insights into the genetic and molecular features that drive tumorigenesis, disease progression, and therapy resistance. However, despite advances in single-cell technologies, challenges such as high costs, complex data analysis and interpretation, and difficulties in translating findings into clinical practice persist. As single-cell technologies are developed further, more insights into the cellular and molecular heterogeneity of glioblastomas are expected, which will help guide the development of personalized and effective therapies, thereby improving prognosis and quality of life for patients.https://doi.org/10.1371/journal.pbio.3002640 |
| spellingShingle | Yahaya A Yabo Dieter Henrik Heiland Understanding glioblastoma at the single-cell level: Recent advances and future challenges. PLoS Biology |
| title | Understanding glioblastoma at the single-cell level: Recent advances and future challenges. |
| title_full | Understanding glioblastoma at the single-cell level: Recent advances and future challenges. |
| title_fullStr | Understanding glioblastoma at the single-cell level: Recent advances and future challenges. |
| title_full_unstemmed | Understanding glioblastoma at the single-cell level: Recent advances and future challenges. |
| title_short | Understanding glioblastoma at the single-cell level: Recent advances and future challenges. |
| title_sort | understanding glioblastoma at the single cell level recent advances and future challenges |
| url | https://doi.org/10.1371/journal.pbio.3002640 |
| work_keys_str_mv | AT yahayaayabo understandingglioblastomaatthesinglecelllevelrecentadvancesandfuturechallenges AT dieterhenrikheiland understandingglioblastomaatthesinglecelllevelrecentadvancesandfuturechallenges |