Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis
Objective. Atrial Natriuretic Peptide (ANP) has natriuretic and diuretic effects, synthesized and stored in the atrial cells, released in response to stretch of the atrial muscle during increase venous return. Acute gastroenteritis (AGE) causes dehydration. We intend to determine whether the decreas...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2009/623871 |
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| author | A. Klar E. Haver D. Lichtstein H. Hurvitz T. Foah-Shauli |
| author_facet | A. Klar E. Haver D. Lichtstein H. Hurvitz T. Foah-Shauli |
| author_sort | A. Klar |
| collection | DOAJ |
| description | Objective. Atrial Natriuretic Peptide (ANP) has natriuretic and diuretic effects, synthesized and stored in the atrial cells, released in response to stretch of the atrial muscle during increase venous return. Acute gastroenteritis (AGE) causes dehydration. We intend to determine whether the decrease in venous return due to dehydration would lead to a decrease in ANP levels. Patients and Methods. This is a prospective observational controlled study. Blood collected from 30 children with AGE and ANP's levels were compared with 25 controls. ANP levels were determined by radioimmunoassay. Results. The study group was in mild dehydration. As a significant difference was found in ANP levels between children in the 3mo–3y group and older children 3y–14y. We analyzed the results according to age. No difference was found between children with AGE and control, in the 3mo–3y, ANP was 12.1 ± 11 pg/ml versus 13.4 ± 12 pg/ml respectively, and 3 ± 2 versus 3.8 ± 3 pg/ml in the 3y–14y groups, respectively. Conclusion. Dehydration due to AGE does not change the ANP's plasma levels. A weak positive correlation between sodium levels and ANP was found
r=0.29. The significant finding of our study is the difference in ANP levels related to age, in the control as well as the GE group. |
| format | Article |
| id | doaj-art-6e1c22f0315a49c2a5ef325bedd0c121 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-6e1c22f0315a49c2a5ef325bedd0c1212025-02-03T06:06:47ZengWileyGastroenterology Research and Practice1687-61211687-630X2009-01-01200910.1155/2009/623871623871Atrial Natriuretic Peptide in Young and Elderly Children with Mild GastroenteritisA. Klar0E. Haver1D. Lichtstein2H. Hurvitz3T. Foah-Shauli4Pediatric Gastroenterology Unit, Department of Pediatrics, Bikur Cholim General Hospital, P. O. Box 492, Jerusalem 91004, IsraelMedical Administration, Kaplan-Harzfeld Medical Center, Rehovot, IsraelDepartment of Physiology, Hebrew University-Hadassah Medical School, Jerusalem, IsraelDepartment of Pediatrics, Bikur Cholim General Hospital, Hebrew University-Hadassah Medical School, Jerusalem, IsraelDepartment of Pediatrics, Bikur Cholim General Hospital, Hebrew University-Hadassah Medical School, Jerusalem, IsraelObjective. Atrial Natriuretic Peptide (ANP) has natriuretic and diuretic effects, synthesized and stored in the atrial cells, released in response to stretch of the atrial muscle during increase venous return. Acute gastroenteritis (AGE) causes dehydration. We intend to determine whether the decrease in venous return due to dehydration would lead to a decrease in ANP levels. Patients and Methods. This is a prospective observational controlled study. Blood collected from 30 children with AGE and ANP's levels were compared with 25 controls. ANP levels were determined by radioimmunoassay. Results. The study group was in mild dehydration. As a significant difference was found in ANP levels between children in the 3mo–3y group and older children 3y–14y. We analyzed the results according to age. No difference was found between children with AGE and control, in the 3mo–3y, ANP was 12.1 ± 11 pg/ml versus 13.4 ± 12 pg/ml respectively, and 3 ± 2 versus 3.8 ± 3 pg/ml in the 3y–14y groups, respectively. Conclusion. Dehydration due to AGE does not change the ANP's plasma levels. A weak positive correlation between sodium levels and ANP was found r=0.29. The significant finding of our study is the difference in ANP levels related to age, in the control as well as the GE group.http://dx.doi.org/10.1155/2009/623871 |
| spellingShingle | A. Klar E. Haver D. Lichtstein H. Hurvitz T. Foah-Shauli Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis Gastroenterology Research and Practice |
| title | Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis |
| title_full | Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis |
| title_fullStr | Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis |
| title_full_unstemmed | Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis |
| title_short | Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis |
| title_sort | atrial natriuretic peptide in young and elderly children with mild gastroenteritis |
| url | http://dx.doi.org/10.1155/2009/623871 |
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