High and Low Annealing Temperatures Increase Both Specificity and Yield in Touchdown and Stepdown PCR

Touchdown (TD) PCR represents a versatile one-step procedure for optimizing PCRs even if the degree of primer-template complementarity is not fully known. The protocol relies on incremental annealing temperature decreases in progressive cycles designed to bracket the melting temperature (Tm) of the...

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Bibliographic Details
Main Authors: Karl H. Hecker, Kenneth H. Roux
Format: Article
Language:English
Published: Taylor & Francis Group 1996-03-01
Series:BioTechniques
Online Access:https://www.future-science.com/doi/10.2144/19962003478
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