Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke

BackgroundThe prognostic significance of hemoglobin glycation index (HGI) on acute ischemic stroke (AIS) patients treated with endovascular thrombectomy (EVT) remained unclear. This study aimed to investigate the association between HGI and the risk of poor outcome after EVT.MethodsWe retrospectivel...

Full description

Saved in:
Bibliographic Details
Main Authors: Yan Yang, Mei Liu, Shungui Huang, Chen Zhu, Guangzong Li, Bin Wang, Xiaojing Luo, Lingwen Zhang, Weizheng Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1533584/full
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832542311572045824
author Yan Yang
Mei Liu
Shungui Huang
Chen Zhu
Guangzong Li
Bin Wang
Xiaojing Luo
Lingwen Zhang
Weizheng Song
author_facet Yan Yang
Mei Liu
Shungui Huang
Chen Zhu
Guangzong Li
Bin Wang
Xiaojing Luo
Lingwen Zhang
Weizheng Song
author_sort Yan Yang
collection DOAJ
description BackgroundThe prognostic significance of hemoglobin glycation index (HGI) on acute ischemic stroke (AIS) patients treated with endovascular thrombectomy (EVT) remained unclear. This study aimed to investigate the association between HGI and the risk of poor outcome after EVT.MethodsWe retrospectively enrolled AIS patients with large vessel occlusion in the anterior circulation treated with EVT from a multicenter study. Poor outcome was defined as a modified Rankin scale score > 2 points at 90 days after EVT. We used multivariable logistic regression models to investigate the association between HGI and poor outcome. We employed the restricted cubic spline curve to visualize the association between HGI and the risk of poor outcome after EVT.ResultsAmong the 403 enrolled patients (median age, 72 years; 63.8% male), a total of 198 (49.1%) patients had poor outcome at 90 days. The restricted cubic spline curve showed that there was a U-shape relationship between HGI and the risk of poor outcome (P for non-linearity < 0.001). After divided patients into three groups based on HGI tertiles, HGI (tertile 1 vs. 2) was significantly associated with poor outcome [odds ratio (OR), 3.84; 95% confidence interval (CI), 2.08–7.22; P < 0.001] and early neurological deterioration (OR, 3.11; 95% CI, 1.55–6.44; P = 0.002) in multivariable analyses. Adding HGI into models improved the discriminative ability for poor outcome (P < 0.001).ConclusionIn conclusion, our study identified a U-shaped relationship between HGI and poor outcome, with low HGI levels significantly associated with poor outcome after EVT.
format Article
id doaj-art-6e158b29a4b44a83ab0cb2902441bbd0
institution Kabale University
issn 1663-4365
language English
publishDate 2025-02-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Aging Neuroscience
spelling doaj-art-6e158b29a4b44a83ab0cb2902441bbd02025-02-04T06:31:52ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-02-011710.3389/fnagi.2025.15335841533584Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic strokeYan Yang0Mei Liu1Shungui Huang2Chen Zhu3Guangzong Li4Bin Wang5Xiaojing Luo6Lingwen Zhang7Weizheng Song8Department of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, Affiliated Hospital of Panzhihua University, Panzhihua, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaBackgroundThe prognostic significance of hemoglobin glycation index (HGI) on acute ischemic stroke (AIS) patients treated with endovascular thrombectomy (EVT) remained unclear. This study aimed to investigate the association between HGI and the risk of poor outcome after EVT.MethodsWe retrospectively enrolled AIS patients with large vessel occlusion in the anterior circulation treated with EVT from a multicenter study. Poor outcome was defined as a modified Rankin scale score > 2 points at 90 days after EVT. We used multivariable logistic regression models to investigate the association between HGI and poor outcome. We employed the restricted cubic spline curve to visualize the association between HGI and the risk of poor outcome after EVT.ResultsAmong the 403 enrolled patients (median age, 72 years; 63.8% male), a total of 198 (49.1%) patients had poor outcome at 90 days. The restricted cubic spline curve showed that there was a U-shape relationship between HGI and the risk of poor outcome (P for non-linearity < 0.001). After divided patients into three groups based on HGI tertiles, HGI (tertile 1 vs. 2) was significantly associated with poor outcome [odds ratio (OR), 3.84; 95% confidence interval (CI), 2.08–7.22; P < 0.001] and early neurological deterioration (OR, 3.11; 95% CI, 1.55–6.44; P = 0.002) in multivariable analyses. Adding HGI into models improved the discriminative ability for poor outcome (P < 0.001).ConclusionIn conclusion, our study identified a U-shaped relationship between HGI and poor outcome, with low HGI levels significantly associated with poor outcome after EVT.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1533584/fullhemoglobinstrokethrombectomyHbA1coutcome
spellingShingle Yan Yang
Mei Liu
Shungui Huang
Chen Zhu
Guangzong Li
Bin Wang
Xiaojing Luo
Lingwen Zhang
Weizheng Song
Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke
Frontiers in Aging Neuroscience
hemoglobin
stroke
thrombectomy
HbA1c
outcome
title Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke
title_full Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke
title_fullStr Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke
title_full_unstemmed Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke
title_short Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke
title_sort association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke
topic hemoglobin
stroke
thrombectomy
HbA1c
outcome
url https://www.frontiersin.org/articles/10.3389/fnagi.2025.1533584/full
work_keys_str_mv AT yanyang associationbetweenhemoglobinglycationindexandpooroutcomeafterendovascularthrombectomyinacuteischemicstroke
AT meiliu associationbetweenhemoglobinglycationindexandpooroutcomeafterendovascularthrombectomyinacuteischemicstroke
AT shunguihuang associationbetweenhemoglobinglycationindexandpooroutcomeafterendovascularthrombectomyinacuteischemicstroke
AT chenzhu associationbetweenhemoglobinglycationindexandpooroutcomeafterendovascularthrombectomyinacuteischemicstroke
AT guangzongli associationbetweenhemoglobinglycationindexandpooroutcomeafterendovascularthrombectomyinacuteischemicstroke
AT binwang associationbetweenhemoglobinglycationindexandpooroutcomeafterendovascularthrombectomyinacuteischemicstroke
AT xiaojingluo associationbetweenhemoglobinglycationindexandpooroutcomeafterendovascularthrombectomyinacuteischemicstroke
AT lingwenzhang associationbetweenhemoglobinglycationindexandpooroutcomeafterendovascularthrombectomyinacuteischemicstroke
AT weizhengsong associationbetweenhemoglobinglycationindexandpooroutcomeafterendovascularthrombectomyinacuteischemicstroke