Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke
BackgroundThe prognostic significance of hemoglobin glycation index (HGI) on acute ischemic stroke (AIS) patients treated with endovascular thrombectomy (EVT) remained unclear. This study aimed to investigate the association between HGI and the risk of poor outcome after EVT.MethodsWe retrospectivel...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1533584/full |
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| author | Yan Yang Mei Liu Shungui Huang Chen Zhu Guangzong Li Bin Wang Xiaojing Luo Lingwen Zhang Weizheng Song |
| author_facet | Yan Yang Mei Liu Shungui Huang Chen Zhu Guangzong Li Bin Wang Xiaojing Luo Lingwen Zhang Weizheng Song |
| author_sort | Yan Yang |
| collection | DOAJ |
| description | BackgroundThe prognostic significance of hemoglobin glycation index (HGI) on acute ischemic stroke (AIS) patients treated with endovascular thrombectomy (EVT) remained unclear. This study aimed to investigate the association between HGI and the risk of poor outcome after EVT.MethodsWe retrospectively enrolled AIS patients with large vessel occlusion in the anterior circulation treated with EVT from a multicenter study. Poor outcome was defined as a modified Rankin scale score > 2 points at 90 days after EVT. We used multivariable logistic regression models to investigate the association between HGI and poor outcome. We employed the restricted cubic spline curve to visualize the association between HGI and the risk of poor outcome after EVT.ResultsAmong the 403 enrolled patients (median age, 72 years; 63.8% male), a total of 198 (49.1%) patients had poor outcome at 90 days. The restricted cubic spline curve showed that there was a U-shape relationship between HGI and the risk of poor outcome (P for non-linearity < 0.001). After divided patients into three groups based on HGI tertiles, HGI (tertile 1 vs. 2) was significantly associated with poor outcome [odds ratio (OR), 3.84; 95% confidence interval (CI), 2.08–7.22; P < 0.001] and early neurological deterioration (OR, 3.11; 95% CI, 1.55–6.44; P = 0.002) in multivariable analyses. Adding HGI into models improved the discriminative ability for poor outcome (P < 0.001).ConclusionIn conclusion, our study identified a U-shaped relationship between HGI and poor outcome, with low HGI levels significantly associated with poor outcome after EVT. |
| format | Article |
| id | doaj-art-6e158b29a4b44a83ab0cb2902441bbd0 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-6e158b29a4b44a83ab0cb2902441bbd02025-02-04T06:31:52ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-02-011710.3389/fnagi.2025.15335841533584Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic strokeYan Yang0Mei Liu1Shungui Huang2Chen Zhu3Guangzong Li4Bin Wang5Xiaojing Luo6Lingwen Zhang7Weizheng Song8Department of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, Affiliated Hospital of Panzhihua University, Panzhihua, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu, ChinaBackgroundThe prognostic significance of hemoglobin glycation index (HGI) on acute ischemic stroke (AIS) patients treated with endovascular thrombectomy (EVT) remained unclear. This study aimed to investigate the association between HGI and the risk of poor outcome after EVT.MethodsWe retrospectively enrolled AIS patients with large vessel occlusion in the anterior circulation treated with EVT from a multicenter study. Poor outcome was defined as a modified Rankin scale score > 2 points at 90 days after EVT. We used multivariable logistic regression models to investigate the association between HGI and poor outcome. We employed the restricted cubic spline curve to visualize the association between HGI and the risk of poor outcome after EVT.ResultsAmong the 403 enrolled patients (median age, 72 years; 63.8% male), a total of 198 (49.1%) patients had poor outcome at 90 days. The restricted cubic spline curve showed that there was a U-shape relationship between HGI and the risk of poor outcome (P for non-linearity < 0.001). After divided patients into three groups based on HGI tertiles, HGI (tertile 1 vs. 2) was significantly associated with poor outcome [odds ratio (OR), 3.84; 95% confidence interval (CI), 2.08–7.22; P < 0.001] and early neurological deterioration (OR, 3.11; 95% CI, 1.55–6.44; P = 0.002) in multivariable analyses. Adding HGI into models improved the discriminative ability for poor outcome (P < 0.001).ConclusionIn conclusion, our study identified a U-shaped relationship between HGI and poor outcome, with low HGI levels significantly associated with poor outcome after EVT.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1533584/fullhemoglobinstrokethrombectomyHbA1coutcome |
| spellingShingle | Yan Yang Mei Liu Shungui Huang Chen Zhu Guangzong Li Bin Wang Xiaojing Luo Lingwen Zhang Weizheng Song Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke Frontiers in Aging Neuroscience hemoglobin stroke thrombectomy HbA1c outcome |
| title | Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke |
| title_full | Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke |
| title_fullStr | Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke |
| title_full_unstemmed | Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke |
| title_short | Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke |
| title_sort | association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke |
| topic | hemoglobin stroke thrombectomy HbA1c outcome |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1533584/full |
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