Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst)
PurposeTo present the clinical characteristics and management outcomes of Coats disease with retinoschisis (retinal cyst).MethodsThis was a retrospective review of 13 eyes from 13 consecutive Coats disease patients with retinal cyst. Clinical findings from multimodal ophthalmic imaging were recorded...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1369479/full |
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| author | Tingyi Liang Shaochi Zhang Xiang Zhang Xiaohan Wang Xunda Ji Peiquan Zhao |
| author_facet | Tingyi Liang Shaochi Zhang Xiang Zhang Xiaohan Wang Xunda Ji Peiquan Zhao |
| author_sort | Tingyi Liang |
| collection | DOAJ |
| description | PurposeTo present the clinical characteristics and management outcomes of Coats disease with retinoschisis (retinal cyst).MethodsThis was a retrospective review of 13 eyes from 13 consecutive Coats disease patients with retinal cyst. Clinical findings from multimodal ophthalmic imaging were recorded to characterize retinal cyst in Coats disease. All eyes were initially treated with endolaser photocoagulation combined with external drainage of cystic fluid and intravitreal ranibizumab injection. Patients were subsequently followed up to analyze anatomic and visual outcomes.ResultsAll retinal cysts were associated with extensive retinal exudation; 3 eyes (23.1%) presented with exudative retinal detachment. A total of 92.3% (12/13) of the retinal cysts were located in the inferotemporal quadrant. Fluorescein angiography demonstrated telangiectasia surrounding and/or at the edge of the retinal cyst. Eleven eyes (84.6%) underwent endolaser photocoagulation via a nonvitrectomy approach, and 2 eyes (15.4%) underwent endolaser photocoagulation after vitrectomy due to the presence of epiretinal membrane. An average of 1.5 additional laser photocoagulation sessions was performed per patient. After a median follow-up of 23 months (range, 11–33 months), all eyes demonstrated retinal cyst resolution and no active disease. Subretinal fibrosis was observed in 9 eyes (69.2%); of these, 8 had macular subretinal nodules. In total, 30.8% of the eyes had a final vision ≥20/200.ConclusionThe presence of retinoschisis (retinal cyst) in Coats disease is strongly associated with retinal telangiectasia and exudation and is indicative of active vascular disease requiring effective ablative treatment. We propose a novel approach, endolaser photocoagulation combined with external drainage of cystic fluid and intravitreal ranibizumab injection, which was effective in achieving final anatomic improvement with retinal cyst resolution. |
| format | Article |
| id | doaj-art-6e0b108020294a3188df38d311c7c705 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-6e0b108020294a3188df38d311c7c7052025-02-05T07:32:25ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.13694791369479Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst)Tingyi Liang0Shaochi Zhang1Xiang Zhang2Xiaohan Wang3Xunda Ji4Peiquan Zhao5Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Ningxia Eye Hospital, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, ChinaDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaPurposeTo present the clinical characteristics and management outcomes of Coats disease with retinoschisis (retinal cyst).MethodsThis was a retrospective review of 13 eyes from 13 consecutive Coats disease patients with retinal cyst. Clinical findings from multimodal ophthalmic imaging were recorded to characterize retinal cyst in Coats disease. All eyes were initially treated with endolaser photocoagulation combined with external drainage of cystic fluid and intravitreal ranibizumab injection. Patients were subsequently followed up to analyze anatomic and visual outcomes.ResultsAll retinal cysts were associated with extensive retinal exudation; 3 eyes (23.1%) presented with exudative retinal detachment. A total of 92.3% (12/13) of the retinal cysts were located in the inferotemporal quadrant. Fluorescein angiography demonstrated telangiectasia surrounding and/or at the edge of the retinal cyst. Eleven eyes (84.6%) underwent endolaser photocoagulation via a nonvitrectomy approach, and 2 eyes (15.4%) underwent endolaser photocoagulation after vitrectomy due to the presence of epiretinal membrane. An average of 1.5 additional laser photocoagulation sessions was performed per patient. After a median follow-up of 23 months (range, 11–33 months), all eyes demonstrated retinal cyst resolution and no active disease. Subretinal fibrosis was observed in 9 eyes (69.2%); of these, 8 had macular subretinal nodules. In total, 30.8% of the eyes had a final vision ≥20/200.ConclusionThe presence of retinoschisis (retinal cyst) in Coats disease is strongly associated with retinal telangiectasia and exudation and is indicative of active vascular disease requiring effective ablative treatment. We propose a novel approach, endolaser photocoagulation combined with external drainage of cystic fluid and intravitreal ranibizumab injection, which was effective in achieving final anatomic improvement with retinal cyst resolution.https://www.frontiersin.org/articles/10.3389/fmed.2025.1369479/fullCoats diseaseretinoschisisretinal cystclinical characteristicssurgical management |
| spellingShingle | Tingyi Liang Shaochi Zhang Xiang Zhang Xiaohan Wang Xunda Ji Peiquan Zhao Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst) Frontiers in Medicine Coats disease retinoschisis retinal cyst clinical characteristics surgical management |
| title | Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst) |
| title_full | Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst) |
| title_fullStr | Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst) |
| title_full_unstemmed | Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst) |
| title_short | Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst) |
| title_sort | clinical characteristics and management outcomes of pediatric patients with coats disease complicated with retinoschisis retinal cyst |
| topic | Coats disease retinoschisis retinal cyst clinical characteristics surgical management |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1369479/full |
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