Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance
Retroviral and lentiviral vectors have proven to be particularly efficient systems to deliver genes of interest into target cells, either in vivo or in cell cultures. They have been used for some time for gene therapy and the development of gene vaccines. Recently retroviral and lentiviral vectors h...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.6064/2012/694137 |
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| author | Inès Dufait Therese Liechtenstein Alessio Lanna Christopher Bricogne Roberta Laranga Antonella Padella Karine Breckpot David Escors |
| author_facet | Inès Dufait Therese Liechtenstein Alessio Lanna Christopher Bricogne Roberta Laranga Antonella Padella Karine Breckpot David Escors |
| author_sort | Inès Dufait |
| collection | DOAJ |
| description | Retroviral and lentiviral vectors have proven to be particularly efficient systems to deliver genes of interest into target cells, either in vivo or in cell cultures. They have been used for some time for gene therapy and the development of gene vaccines. Recently retroviral and lentiviral vectors have been used to generate tolerogenic dendritic cells, key professional antigen presenting cells that regulate immune responses. Thus, three main approaches have been undertaken to induce immunological tolerance; delivery of potent immunosuppressive cytokines and other molecules, modification of intracellular signalling pathways in dendritic cells, and de-targeting transgene expression from dendritic cells using microRNA technology. In this review we briefly describe retroviral and lentiviral vector biology, and their application to induce immunological tolerance. |
| format | Article |
| id | doaj-art-6e07370133f54efe9b873b01b2905146 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-6e07370133f54efe9b873b01b29051462025-02-03T06:08:12ZengWileyScientifica2090-908X2012-01-01201210.6064/2012/694137694137Retroviral and Lentiviral Vectors for the Induction of Immunological ToleranceInès Dufait0Therese Liechtenstein1Alessio Lanna2Christopher Bricogne3Roberta Laranga4Antonella Padella5Karine Breckpot6David Escors7Division of Infection and Immunity, Rayne Institute, University College London, 5 University Street, London, WC1E 6JF, UKDivision of Infection and Immunity, Rayne Institute, University College London, 5 University Street, London, WC1E 6JF, UKDivision of Infection and Immunity, Rayne Institute, University College London, 5 University Street, London, WC1E 6JF, UKDivision of Infection and Immunity, Rayne Institute, University College London, 5 University Street, London, WC1E 6JF, UKDivision of Infection and Immunity, Rayne Institute, University College London, 5 University Street, London, WC1E 6JF, UKDivision of Infection and Immunity, Rayne Institute, University College London, 5 University Street, London, WC1E 6JF, UKDepartment of Physiology and Immunology, Medical School, Free University of Brussels, Laarbeeklaan 103, 1090 Jette, BelgiumDivision of Infection and Immunity, Rayne Institute, University College London, 5 University Street, London, WC1E 6JF, UKRetroviral and lentiviral vectors have proven to be particularly efficient systems to deliver genes of interest into target cells, either in vivo or in cell cultures. They have been used for some time for gene therapy and the development of gene vaccines. Recently retroviral and lentiviral vectors have been used to generate tolerogenic dendritic cells, key professional antigen presenting cells that regulate immune responses. Thus, three main approaches have been undertaken to induce immunological tolerance; delivery of potent immunosuppressive cytokines and other molecules, modification of intracellular signalling pathways in dendritic cells, and de-targeting transgene expression from dendritic cells using microRNA technology. In this review we briefly describe retroviral and lentiviral vector biology, and their application to induce immunological tolerance.http://dx.doi.org/10.6064/2012/694137 |
| spellingShingle | Inès Dufait Therese Liechtenstein Alessio Lanna Christopher Bricogne Roberta Laranga Antonella Padella Karine Breckpot David Escors Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance Scientifica |
| title | Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance |
| title_full | Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance |
| title_fullStr | Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance |
| title_full_unstemmed | Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance |
| title_short | Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance |
| title_sort | retroviral and lentiviral vectors for the induction of immunological tolerance |
| url | http://dx.doi.org/10.6064/2012/694137 |
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