Solid Indeterminate Nodules with a Radiological Stability Suggesting Benignity: A Texture Analysis of Computed Tomography Images Based on the Kurtosis and Skewness of the Nodule Volume Density Histogram
Background. The number of incidental findings of pulmonary nodules using imaging methods to diagnose other thoracic or extrathoracic conditions has increased, suggesting the need for in-depth radiological image analyses to identify nodule type and avoid unnecessary invasive procedures. Objectives. T...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/4071762 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554224363241472 |
|---|---|
| author | Bruno Max Borguezan Agnaldo José Lopes Eduardo Haruo Saito Claudio Higa Aristófanes Corrêa Silva Rodolfo Acatauassú Nunes |
| author_facet | Bruno Max Borguezan Agnaldo José Lopes Eduardo Haruo Saito Claudio Higa Aristófanes Corrêa Silva Rodolfo Acatauassú Nunes |
| author_sort | Bruno Max Borguezan |
| collection | DOAJ |
| description | Background. The number of incidental findings of pulmonary nodules using imaging methods to diagnose other thoracic or extrathoracic conditions has increased, suggesting the need for in-depth radiological image analyses to identify nodule type and avoid unnecessary invasive procedures. Objectives. The present study evaluated solid indeterminate nodules with a radiological stability suggesting benignity (SINRSBs) through a texture analysis of computed tomography (CT) images. Methods. A total of 100 chest CT scans were evaluated, including 50 cases of SINRSBs and 50 cases of malignant nodules. SINRSB CT scans were performed using the same noncontrast enhanced CT protocol and equipment; the malignant nodule data were acquired from several databases. The kurtosis (KUR) and skewness (SKW) values of these tests were determined for the whole volume of each nodule, and the histograms were classified into two basic patterns: peaks or plateaus. Results. The mean (MEN) KUR values of the SINRSBs and malignant nodules were 3.37 ± 3.88 and 5.88 ± 5.11, respectively. The receiver operating characteristic (ROC) curve showed that the sensitivity and specificity for distinguishing SINRSBs from malignant nodules were 65% and 66% for KUR values >6, respectively, with an area under the curve (AUC) of 0.709 (p<0.0001). The MEN SKW values of the SINRSBs and malignant nodules were 1.73 ± 0.94 and 2.07 ± 1.01, respectively. The ROC curve showed that the sensitivity and specificity for distinguishing malignant nodules from SINRSBs were 65% and 66% for SKW values >3.1, respectively, with an AUC of 0.709 (p<0.0001). An analysis of the peak and plateau histograms revealed sensitivity, specificity, and accuracy values of 84%, 74%, and 79%, respectively. Conclusions. KUR, SKW, and histogram shape can help to noninvasively diagnose SINRSBs but should not be used alone or without considering clinical data. |
| format | Article |
| id | doaj-art-6e04aea5a06e4eec8375497502fb485b |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-6e04aea5a06e4eec8375497502fb485b2025-02-03T05:52:06ZengWileyPulmonary Medicine2090-18362090-18442019-01-01201910.1155/2019/40717624071762Solid Indeterminate Nodules with a Radiological Stability Suggesting Benignity: A Texture Analysis of Computed Tomography Images Based on the Kurtosis and Skewness of the Nodule Volume Density HistogramBruno Max Borguezan0Agnaldo José Lopes1Eduardo Haruo Saito2Claudio Higa3Aristófanes Corrêa Silva4Rodolfo Acatauassú Nunes5Post-graduate Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, BrazilPost-graduate Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, BrazilPost-graduate Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, BrazilDivision of Thoracic Surgery, Pedro Ernesto University Hospital, State University of Rio de Janeiro, Rio de Janeiro, BrazilTechnology Centre, Federal University of Maranhão, São Luis, BrazilPost-graduate Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, BrazilBackground. The number of incidental findings of pulmonary nodules using imaging methods to diagnose other thoracic or extrathoracic conditions has increased, suggesting the need for in-depth radiological image analyses to identify nodule type and avoid unnecessary invasive procedures. Objectives. The present study evaluated solid indeterminate nodules with a radiological stability suggesting benignity (SINRSBs) through a texture analysis of computed tomography (CT) images. Methods. A total of 100 chest CT scans were evaluated, including 50 cases of SINRSBs and 50 cases of malignant nodules. SINRSB CT scans were performed using the same noncontrast enhanced CT protocol and equipment; the malignant nodule data were acquired from several databases. The kurtosis (KUR) and skewness (SKW) values of these tests were determined for the whole volume of each nodule, and the histograms were classified into two basic patterns: peaks or plateaus. Results. The mean (MEN) KUR values of the SINRSBs and malignant nodules were 3.37 ± 3.88 and 5.88 ± 5.11, respectively. The receiver operating characteristic (ROC) curve showed that the sensitivity and specificity for distinguishing SINRSBs from malignant nodules were 65% and 66% for KUR values >6, respectively, with an area under the curve (AUC) of 0.709 (p<0.0001). The MEN SKW values of the SINRSBs and malignant nodules were 1.73 ± 0.94 and 2.07 ± 1.01, respectively. The ROC curve showed that the sensitivity and specificity for distinguishing malignant nodules from SINRSBs were 65% and 66% for SKW values >3.1, respectively, with an AUC of 0.709 (p<0.0001). An analysis of the peak and plateau histograms revealed sensitivity, specificity, and accuracy values of 84%, 74%, and 79%, respectively. Conclusions. KUR, SKW, and histogram shape can help to noninvasively diagnose SINRSBs but should not be used alone or without considering clinical data.http://dx.doi.org/10.1155/2019/4071762 |
| spellingShingle | Bruno Max Borguezan Agnaldo José Lopes Eduardo Haruo Saito Claudio Higa Aristófanes Corrêa Silva Rodolfo Acatauassú Nunes Solid Indeterminate Nodules with a Radiological Stability Suggesting Benignity: A Texture Analysis of Computed Tomography Images Based on the Kurtosis and Skewness of the Nodule Volume Density Histogram Pulmonary Medicine |
| title | Solid Indeterminate Nodules with a Radiological Stability Suggesting Benignity: A Texture Analysis of Computed Tomography Images Based on the Kurtosis and Skewness of the Nodule Volume Density Histogram |
| title_full | Solid Indeterminate Nodules with a Radiological Stability Suggesting Benignity: A Texture Analysis of Computed Tomography Images Based on the Kurtosis and Skewness of the Nodule Volume Density Histogram |
| title_fullStr | Solid Indeterminate Nodules with a Radiological Stability Suggesting Benignity: A Texture Analysis of Computed Tomography Images Based on the Kurtosis and Skewness of the Nodule Volume Density Histogram |
| title_full_unstemmed | Solid Indeterminate Nodules with a Radiological Stability Suggesting Benignity: A Texture Analysis of Computed Tomography Images Based on the Kurtosis and Skewness of the Nodule Volume Density Histogram |
| title_short | Solid Indeterminate Nodules with a Radiological Stability Suggesting Benignity: A Texture Analysis of Computed Tomography Images Based on the Kurtosis and Skewness of the Nodule Volume Density Histogram |
| title_sort | solid indeterminate nodules with a radiological stability suggesting benignity a texture analysis of computed tomography images based on the kurtosis and skewness of the nodule volume density histogram |
| url | http://dx.doi.org/10.1155/2019/4071762 |
| work_keys_str_mv | AT brunomaxborguezan solidindeterminatenoduleswitharadiologicalstabilitysuggestingbenignityatextureanalysisofcomputedtomographyimagesbasedonthekurtosisandskewnessofthenodulevolumedensityhistogram AT agnaldojoselopes solidindeterminatenoduleswitharadiologicalstabilitysuggestingbenignityatextureanalysisofcomputedtomographyimagesbasedonthekurtosisandskewnessofthenodulevolumedensityhistogram AT eduardoharuosaito solidindeterminatenoduleswitharadiologicalstabilitysuggestingbenignityatextureanalysisofcomputedtomographyimagesbasedonthekurtosisandskewnessofthenodulevolumedensityhistogram AT claudiohiga solidindeterminatenoduleswitharadiologicalstabilitysuggestingbenignityatextureanalysisofcomputedtomographyimagesbasedonthekurtosisandskewnessofthenodulevolumedensityhistogram AT aristofanescorreasilva solidindeterminatenoduleswitharadiologicalstabilitysuggestingbenignityatextureanalysisofcomputedtomographyimagesbasedonthekurtosisandskewnessofthenodulevolumedensityhistogram AT rodolfoacatauassununes solidindeterminatenoduleswitharadiologicalstabilitysuggestingbenignityatextureanalysisofcomputedtomographyimagesbasedonthekurtosisandskewnessofthenodulevolumedensityhistogram |