Successful Treatment of High-Level Aminoglycoside-Resistant Enterococcus faecalis Bacteremia in a Preterm Infant with Ampicillin and Cefotaxime
Enterococcal bloodstream infections are usually treated with single-agent antibiotics. In persistent infections, synergistic combination therapy is often required with a beta-lactam and an aminoglycoside antibiotic. High-level aminoglycoside-resistant (HLAR) enterococci are increasingly prevalent an...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2018/7567914 |
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| author | Jennifer Tam Santina J. Lee Vibhuti Shah Shaun K. Morris |
| author_facet | Jennifer Tam Santina J. Lee Vibhuti Shah Shaun K. Morris |
| author_sort | Jennifer Tam |
| collection | DOAJ |
| description | Enterococcal bloodstream infections are usually treated with single-agent antibiotics. In persistent infections, synergistic combination therapy is often required with a beta-lactam and an aminoglycoside antibiotic. High-level aminoglycoside-resistant (HLAR) enterococci are increasingly prevalent and preclude the use of this combination. The use of ampicillin with a third-generation cephalosporin to treat endovascular HLAR Enterococcus infections is becoming more established in the adult population; however, the literature on treatment of such infections in children remains scarce. We report a preterm neonate with persistent HLAR Enterococcus faecalis bacteremia from day of life 9 to 17 despite treatment with ampicillin and vancomycin. On day of life 17, antibiotic treatment was switched to ampicillin and cefotaxime, with subsequent clearance of blood cultures on day of life 20. To our knowledge, this is the first report illustrating the use of ampicillin and cefotaxime for an HLAR E. faecalis infection in a neonate. |
| format | Article |
| id | doaj-art-6e0429e8a8c84bc88fec7f65ac761902 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-6e0429e8a8c84bc88fec7f65ac7619022025-02-03T06:42:25ZengWileyCase Reports in Infectious Diseases2090-66252090-66332018-01-01201810.1155/2018/75679147567914Successful Treatment of High-Level Aminoglycoside-Resistant Enterococcus faecalis Bacteremia in a Preterm Infant with Ampicillin and CefotaximeJennifer Tam0Santina J. Lee1Vibhuti Shah2Shaun K. Morris3Division of Infectious Diseases, The Hospital for Sick Children, 555 University Ave., Toronto, ON, CanadaDepartment of Pediatrics and Child Health, University of Manitoba, 840 Sherbrook St., Winnipeg, MB, CanadaDepartment of Paediatrics, Mount Sinai Hospital, 600 University Ave., Toronto, ON, CanadaDivision of Infectious Diseases, The Hospital for Sick Children, 555 University Ave., Toronto, ON, CanadaEnterococcal bloodstream infections are usually treated with single-agent antibiotics. In persistent infections, synergistic combination therapy is often required with a beta-lactam and an aminoglycoside antibiotic. High-level aminoglycoside-resistant (HLAR) enterococci are increasingly prevalent and preclude the use of this combination. The use of ampicillin with a third-generation cephalosporin to treat endovascular HLAR Enterococcus infections is becoming more established in the adult population; however, the literature on treatment of such infections in children remains scarce. We report a preterm neonate with persistent HLAR Enterococcus faecalis bacteremia from day of life 9 to 17 despite treatment with ampicillin and vancomycin. On day of life 17, antibiotic treatment was switched to ampicillin and cefotaxime, with subsequent clearance of blood cultures on day of life 20. To our knowledge, this is the first report illustrating the use of ampicillin and cefotaxime for an HLAR E. faecalis infection in a neonate.http://dx.doi.org/10.1155/2018/7567914 |
| spellingShingle | Jennifer Tam Santina J. Lee Vibhuti Shah Shaun K. Morris Successful Treatment of High-Level Aminoglycoside-Resistant Enterococcus faecalis Bacteremia in a Preterm Infant with Ampicillin and Cefotaxime Case Reports in Infectious Diseases |
| title | Successful Treatment of High-Level Aminoglycoside-Resistant Enterococcus faecalis Bacteremia in a Preterm Infant with Ampicillin and Cefotaxime |
| title_full | Successful Treatment of High-Level Aminoglycoside-Resistant Enterococcus faecalis Bacteremia in a Preterm Infant with Ampicillin and Cefotaxime |
| title_fullStr | Successful Treatment of High-Level Aminoglycoside-Resistant Enterococcus faecalis Bacteremia in a Preterm Infant with Ampicillin and Cefotaxime |
| title_full_unstemmed | Successful Treatment of High-Level Aminoglycoside-Resistant Enterococcus faecalis Bacteremia in a Preterm Infant with Ampicillin and Cefotaxime |
| title_short | Successful Treatment of High-Level Aminoglycoside-Resistant Enterococcus faecalis Bacteremia in a Preterm Infant with Ampicillin and Cefotaxime |
| title_sort | successful treatment of high level aminoglycoside resistant enterococcus faecalis bacteremia in a preterm infant with ampicillin and cefotaxime |
| url | http://dx.doi.org/10.1155/2018/7567914 |
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