Role of macrophage in intervertebral disc degeneration
Abstract Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years, the role of macrophages in inflammat...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-024-00397-7 |
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| _version_ | 1832585993077653504 |
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| author | Yiming Dou Yiming Zhang Yang Liu Xun Sun Xinyu Liu Bin Li Qiang Yang |
| author_facet | Yiming Dou Yiming Zhang Yang Liu Xun Sun Xinyu Liu Bin Li Qiang Yang |
| author_sort | Yiming Dou |
| collection | DOAJ |
| description | Abstract Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years, the role of macrophages in inflammation-related degenerative diseases, such as intervertebral disc degeneration, has been increasingly recognized. Macrophages construct the inflammatory microenvironment of the intervertebral disc and are involved in regulating intervertebral disc cell activities, extracellular matrix metabolism, intervertebral disc vascularization, and innervation, profoundly influencing the progression of disc degeneration. To gain a deeper understanding of the inflammatory microenvironment of intervertebral disc degeneration, this review will summarize the role of macrophages in the pathological process of intervertebral disc degeneration, analyze the regulatory mechanisms involving macrophages, and review therapeutic strategies targeting macrophage modulation for the treatment of intervertebral disc degeneration. These insights will be valuable for the treatment and research directions of intervertebral disc degeneration. |
| format | Article |
| id | doaj-art-6e0141ddc648438582944a68e961da70 |
| institution | Kabale University |
| issn | 2095-6231 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj-art-6e0141ddc648438582944a68e961da702025-01-26T12:19:49ZengNature Publishing GroupBone Research2095-62312025-01-0113112010.1038/s41413-024-00397-7Role of macrophage in intervertebral disc degenerationYiming Dou0Yiming Zhang1Yang Liu2Xun Sun3Xinyu Liu4Bin Li5Qiang Yang6Department of Spine Surgery, Tianjin Hospital, Tianjin UniversityDepartment of Spine Surgery, Tianjin Hospital, Tianjin UniversityDepartment of Spine Surgery, Tianjin Hospital, Tianjin UniversityDepartment of Spine Surgery, Tianjin Hospital, Tianjin UniversityDepartment of Orthopaedics, Qilu Hospital of Shandong UniversityOrthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Biology & Basic Medical Sciences, Suzhou Medical College, Soochow UniversityDepartment of Spine Surgery, Tianjin Hospital, Tianjin UniversityAbstract Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years, the role of macrophages in inflammation-related degenerative diseases, such as intervertebral disc degeneration, has been increasingly recognized. Macrophages construct the inflammatory microenvironment of the intervertebral disc and are involved in regulating intervertebral disc cell activities, extracellular matrix metabolism, intervertebral disc vascularization, and innervation, profoundly influencing the progression of disc degeneration. To gain a deeper understanding of the inflammatory microenvironment of intervertebral disc degeneration, this review will summarize the role of macrophages in the pathological process of intervertebral disc degeneration, analyze the regulatory mechanisms involving macrophages, and review therapeutic strategies targeting macrophage modulation for the treatment of intervertebral disc degeneration. These insights will be valuable for the treatment and research directions of intervertebral disc degeneration.https://doi.org/10.1038/s41413-024-00397-7 |
| spellingShingle | Yiming Dou Yiming Zhang Yang Liu Xun Sun Xinyu Liu Bin Li Qiang Yang Role of macrophage in intervertebral disc degeneration Bone Research |
| title | Role of macrophage in intervertebral disc degeneration |
| title_full | Role of macrophage in intervertebral disc degeneration |
| title_fullStr | Role of macrophage in intervertebral disc degeneration |
| title_full_unstemmed | Role of macrophage in intervertebral disc degeneration |
| title_short | Role of macrophage in intervertebral disc degeneration |
| title_sort | role of macrophage in intervertebral disc degeneration |
| url | https://doi.org/10.1038/s41413-024-00397-7 |
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