Acute Appendicitis in a Man Undergoing Therapy for Mantle Cell Lymphoma
A 71-year-old man was diagnosed with an aggressive mantle cell lymphoma and was started on six cycles of R-CHOP chemotherapy. Approximately two weeks after starting his first cycle of chemotherapy, he complained of severe right lower quadrant abdominal pain, and an abdominal CT scan demonstrated an...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/868151 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566824023097344 |
|---|---|
| author | Michael Linden Ajay Gopal Kerstin Edlefsen |
| author_facet | Michael Linden Ajay Gopal Kerstin Edlefsen |
| author_sort | Michael Linden |
| collection | DOAJ |
| description | A 71-year-old man was diagnosed with an aggressive mantle cell lymphoma and was started on six cycles of R-CHOP chemotherapy. Approximately two weeks after starting his first cycle of chemotherapy, he complained of severe right lower quadrant abdominal pain, and an abdominal CT scan demonstrated an enlarged appendix with evidence of contained perforation. The man underwent open appendectomy for acute appendicitis and recovered. The appendectomy specimen was submitted for routine pathological analysis. There was histologic evidence of perforation in association with an inflammatory infiltrate with fibrin adhered to the serosal surface; scattered small lymphoid aggregates were present on the mucosal surface. Although the lymphoid aggregates in the submucosa and lamina propria were rather unremarkable by routine histologic examination, immunohistochemistry revealed the lymphocytes to be predominantly Cyclin D1-overexpressing B cells. To our knowledge, this is the first reported case of acute appendicitis in association with appendiceal involvement by mantle cell lymphoma. |
| format | Article |
| id | doaj-art-6dfc554101ca49f49d460d492ff13504 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-6dfc554101ca49f49d460d492ff135042025-02-03T01:03:02ZengWileyCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/868151868151Acute Appendicitis in a Man Undergoing Therapy for Mantle Cell LymphomaMichael Linden0Ajay Gopal1Kerstin Edlefsen2Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 806, Minneapolis, MN 55455, USADepartment of Medicine, University of Washington, Seattle, WA 98195, USASeattle Cancer Care Alliance, Seattle, WA 98109, USAA 71-year-old man was diagnosed with an aggressive mantle cell lymphoma and was started on six cycles of R-CHOP chemotherapy. Approximately two weeks after starting his first cycle of chemotherapy, he complained of severe right lower quadrant abdominal pain, and an abdominal CT scan demonstrated an enlarged appendix with evidence of contained perforation. The man underwent open appendectomy for acute appendicitis and recovered. The appendectomy specimen was submitted for routine pathological analysis. There was histologic evidence of perforation in association with an inflammatory infiltrate with fibrin adhered to the serosal surface; scattered small lymphoid aggregates were present on the mucosal surface. Although the lymphoid aggregates in the submucosa and lamina propria were rather unremarkable by routine histologic examination, immunohistochemistry revealed the lymphocytes to be predominantly Cyclin D1-overexpressing B cells. To our knowledge, this is the first reported case of acute appendicitis in association with appendiceal involvement by mantle cell lymphoma.http://dx.doi.org/10.1155/2012/868151 |
| spellingShingle | Michael Linden Ajay Gopal Kerstin Edlefsen Acute Appendicitis in a Man Undergoing Therapy for Mantle Cell Lymphoma Case Reports in Hematology |
| title | Acute Appendicitis in a Man Undergoing Therapy for Mantle Cell Lymphoma |
| title_full | Acute Appendicitis in a Man Undergoing Therapy for Mantle Cell Lymphoma |
| title_fullStr | Acute Appendicitis in a Man Undergoing Therapy for Mantle Cell Lymphoma |
| title_full_unstemmed | Acute Appendicitis in a Man Undergoing Therapy for Mantle Cell Lymphoma |
| title_short | Acute Appendicitis in a Man Undergoing Therapy for Mantle Cell Lymphoma |
| title_sort | acute appendicitis in a man undergoing therapy for mantle cell lymphoma |
| url | http://dx.doi.org/10.1155/2012/868151 |
| work_keys_str_mv | AT michaellinden acuteappendicitisinamanundergoingtherapyformantlecelllymphoma AT ajaygopal acuteappendicitisinamanundergoingtherapyformantlecelllymphoma AT kerstinedlefsen acuteappendicitisinamanundergoingtherapyformantlecelllymphoma |