Impact of a Plant Sterol Food Supplement on Eryptotic and Associated Cardiometabolic Parameters: A Randomized Placebo-Controlled Trial in Statin-Treated Patients
Eryptotic erythrocytes are prone to adhere to the vascular endothelium, provoking atherosclerosis. As statins do not prevent eryptosis compounds with anti-eryptotic effects could help treated hypercholesterolemic subjects in decreasing cardiovascular disease risk. Plant sterols (PSs) have shown this...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/13/24/4108 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850241960748515328 |
|---|---|
| author | Diego Miedes Raquel Ortega-Luna Sonia Broseta Sergio Martínez-Hervás Ángeles Álvarez-Ribelles Víctor Collado-Díaz Antonio Cilla Amparo Alegría |
| author_facet | Diego Miedes Raquel Ortega-Luna Sonia Broseta Sergio Martínez-Hervás Ángeles Álvarez-Ribelles Víctor Collado-Díaz Antonio Cilla Amparo Alegría |
| author_sort | Diego Miedes |
| collection | DOAJ |
| description | Eryptotic erythrocytes are prone to adhere to the vascular endothelium, provoking atherosclerosis. As statins do not prevent eryptosis compounds with anti-eryptotic effects could help treated hypercholesterolemic subjects in decreasing cardiovascular disease risk. Plant sterols (PSs) have shown this anti-eryptotic effect ex vivo, along with their cholesterol-lowering activity. A parallel double-blind placebo-controlled randomized trial was conducted using a PS-food supplement (2 g of PS/day) (case, n = 13) or a placebo supplement (control, n = 13) in statin-treated hypercholesterolemic subjects. Blood samples were extracted before (T0) and after (T1) a 6-week treatment, and erythrocytes were isolated for biochemical determination, phosphatidylserine externalization (EPHS), cell size and reduced glutathione (GSH) analyses, and endothelium adhesion evaluation. A reduction in glucose (4.3%) and LDL cholesterol (9.2%) was observed only in the control group, whereas in the case group, an increase in ApoA1 (6.4%) was observed. Neither EPHS, cell size nor GSH were modified by the treatment with any of the supplements, whilst endothelium adhesion was reduced (55.1%) only in the case group. These results suggest that the PS supplement may improve some cardiovascular health parameters in the target population even though eryptosis status is not modified by this treatment. |
| format | Article |
| id | doaj-art-6df9cfd6cd554d56beef76b6bb6ee2ce |
| institution | OA Journals |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-6df9cfd6cd554d56beef76b6bb6ee2ce2025-08-20T02:00:27ZengMDPI AGFoods2304-81582024-12-011324410810.3390/foods13244108Impact of a Plant Sterol Food Supplement on Eryptotic and Associated Cardiometabolic Parameters: A Randomized Placebo-Controlled Trial in Statin-Treated PatientsDiego Miedes0Raquel Ortega-Luna1Sonia Broseta2Sergio Martínez-Hervás3Ángeles Álvarez-Ribelles4Víctor Collado-Díaz5Antonio Cilla6Amparo Alegría7Nutrition and Food Science Area, Faculty of Pharmacy and Food Sciences, University of Valencia, 46100 Valencia, SpainDepartment of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, SpainNutrition and Food Science Area, Faculty of Pharmacy and Food Sciences, University of Valencia, 46100 Valencia, SpainEndocrinology and Nutrition Department, Hospital Clínico Universitario, 46010 Valencia, SpainDepartment of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, SpainDepartment of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, SpainNutrition and Food Science Area, Faculty of Pharmacy and Food Sciences, University of Valencia, 46100 Valencia, SpainNutrition and Food Science Area, Faculty of Pharmacy and Food Sciences, University of Valencia, 46100 Valencia, SpainEryptotic erythrocytes are prone to adhere to the vascular endothelium, provoking atherosclerosis. As statins do not prevent eryptosis compounds with anti-eryptotic effects could help treated hypercholesterolemic subjects in decreasing cardiovascular disease risk. Plant sterols (PSs) have shown this anti-eryptotic effect ex vivo, along with their cholesterol-lowering activity. A parallel double-blind placebo-controlled randomized trial was conducted using a PS-food supplement (2 g of PS/day) (case, n = 13) or a placebo supplement (control, n = 13) in statin-treated hypercholesterolemic subjects. Blood samples were extracted before (T0) and after (T1) a 6-week treatment, and erythrocytes were isolated for biochemical determination, phosphatidylserine externalization (EPHS), cell size and reduced glutathione (GSH) analyses, and endothelium adhesion evaluation. A reduction in glucose (4.3%) and LDL cholesterol (9.2%) was observed only in the control group, whereas in the case group, an increase in ApoA1 (6.4%) was observed. Neither EPHS, cell size nor GSH were modified by the treatment with any of the supplements, whilst endothelium adhesion was reduced (55.1%) only in the case group. These results suggest that the PS supplement may improve some cardiovascular health parameters in the target population even though eryptosis status is not modified by this treatment.https://www.mdpi.com/2304-8158/13/24/4108hypercholesterolemiaerythrocytesendothelium adhesionatherosclerosisphytosterols |
| spellingShingle | Diego Miedes Raquel Ortega-Luna Sonia Broseta Sergio Martínez-Hervás Ángeles Álvarez-Ribelles Víctor Collado-Díaz Antonio Cilla Amparo Alegría Impact of a Plant Sterol Food Supplement on Eryptotic and Associated Cardiometabolic Parameters: A Randomized Placebo-Controlled Trial in Statin-Treated Patients Foods hypercholesterolemia erythrocytes endothelium adhesion atherosclerosis phytosterols |
| title | Impact of a Plant Sterol Food Supplement on Eryptotic and Associated Cardiometabolic Parameters: A Randomized Placebo-Controlled Trial in Statin-Treated Patients |
| title_full | Impact of a Plant Sterol Food Supplement on Eryptotic and Associated Cardiometabolic Parameters: A Randomized Placebo-Controlled Trial in Statin-Treated Patients |
| title_fullStr | Impact of a Plant Sterol Food Supplement on Eryptotic and Associated Cardiometabolic Parameters: A Randomized Placebo-Controlled Trial in Statin-Treated Patients |
| title_full_unstemmed | Impact of a Plant Sterol Food Supplement on Eryptotic and Associated Cardiometabolic Parameters: A Randomized Placebo-Controlled Trial in Statin-Treated Patients |
| title_short | Impact of a Plant Sterol Food Supplement on Eryptotic and Associated Cardiometabolic Parameters: A Randomized Placebo-Controlled Trial in Statin-Treated Patients |
| title_sort | impact of a plant sterol food supplement on eryptotic and associated cardiometabolic parameters a randomized placebo controlled trial in statin treated patients |
| topic | hypercholesterolemia erythrocytes endothelium adhesion atherosclerosis phytosterols |
| url | https://www.mdpi.com/2304-8158/13/24/4108 |
| work_keys_str_mv | AT diegomiedes impactofaplantsterolfoodsupplementoneryptoticandassociatedcardiometabolicparametersarandomizedplacebocontrolledtrialinstatintreatedpatients AT raquelortegaluna impactofaplantsterolfoodsupplementoneryptoticandassociatedcardiometabolicparametersarandomizedplacebocontrolledtrialinstatintreatedpatients AT soniabroseta impactofaplantsterolfoodsupplementoneryptoticandassociatedcardiometabolicparametersarandomizedplacebocontrolledtrialinstatintreatedpatients AT sergiomartinezhervas impactofaplantsterolfoodsupplementoneryptoticandassociatedcardiometabolicparametersarandomizedplacebocontrolledtrialinstatintreatedpatients AT angelesalvarezribelles impactofaplantsterolfoodsupplementoneryptoticandassociatedcardiometabolicparametersarandomizedplacebocontrolledtrialinstatintreatedpatients AT victorcolladodiaz impactofaplantsterolfoodsupplementoneryptoticandassociatedcardiometabolicparametersarandomizedplacebocontrolledtrialinstatintreatedpatients AT antoniocilla impactofaplantsterolfoodsupplementoneryptoticandassociatedcardiometabolicparametersarandomizedplacebocontrolledtrialinstatintreatedpatients AT amparoalegria impactofaplantsterolfoodsupplementoneryptoticandassociatedcardiometabolicparametersarandomizedplacebocontrolledtrialinstatintreatedpatients |