Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway
As a member of the ezrin-radixin-moesin (ERM) family, radixin is overexpressed in many tumor tissues. However, little is known about its role in the progression of colon cancer. So we here aimed to determine the function of radixin in colon cancer cell invasion. Interestingly, we found that the expr...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/340271 |
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| author | Qi-Hong Jiang Ai-Xiang Wang Yan Chen |
| author_facet | Qi-Hong Jiang Ai-Xiang Wang Yan Chen |
| author_sort | Qi-Hong Jiang |
| collection | DOAJ |
| description | As a member of the ezrin-radixin-moesin (ERM) family, radixin is overexpressed in many tumor tissues. However, little is known about its role in the progression of colon cancer. So we here aimed to determine the function of radixin in colon cancer cell invasion. Interestingly, we found that the expression of radixin was significantly elevated in colon cancer cells. Knockdown of radixin suppressed the invasion and migration of colon cancer cells. Further, knockdown of radixin inhibited the activation of Rac1 and ERK1/2, and decreased the expression and secretion of MMP-7. In addition, Rac1-ERK signaling pathway was required for the radixin-promoted invasion and MMP-7 production. Together, our findings suggest that radixin enhances the invasion and migration of colon cancer cells. Activation of Rac1-ERK pathway and consequent upregulation of MMP-7 production may contribute to the function of radixin in the regulation of colon cancer cell invasion. Thus, radixin may act as a novel target for the diagnosis and treatment of colon cancer. |
| format | Article |
| id | doaj-art-6df8980033624946acf21b02b921555a |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6df8980033624946acf21b02b921555a2025-02-03T01:31:27ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/340271340271Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK PathwayQi-Hong Jiang0Ai-Xiang Wang1Yan Chen2Department of Gastroenterology, Pu’ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, 50 Gu Tian San Road, Wuhan 430034, ChinaDepartment of Gastroenterology, Pu’ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, 50 Gu Tian San Road, Wuhan 430034, ChinaDepartment of Gastroenterology, Pu’ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, 50 Gu Tian San Road, Wuhan 430034, ChinaAs a member of the ezrin-radixin-moesin (ERM) family, radixin is overexpressed in many tumor tissues. However, little is known about its role in the progression of colon cancer. So we here aimed to determine the function of radixin in colon cancer cell invasion. Interestingly, we found that the expression of radixin was significantly elevated in colon cancer cells. Knockdown of radixin suppressed the invasion and migration of colon cancer cells. Further, knockdown of radixin inhibited the activation of Rac1 and ERK1/2, and decreased the expression and secretion of MMP-7. In addition, Rac1-ERK signaling pathway was required for the radixin-promoted invasion and MMP-7 production. Together, our findings suggest that radixin enhances the invasion and migration of colon cancer cells. Activation of Rac1-ERK pathway and consequent upregulation of MMP-7 production may contribute to the function of radixin in the regulation of colon cancer cell invasion. Thus, radixin may act as a novel target for the diagnosis and treatment of colon cancer.http://dx.doi.org/10.1155/2014/340271 |
| spellingShingle | Qi-Hong Jiang Ai-Xiang Wang Yan Chen Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway The Scientific World Journal |
| title | Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway |
| title_full | Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway |
| title_fullStr | Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway |
| title_full_unstemmed | Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway |
| title_short | Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway |
| title_sort | radixin enhances colon cancer cell invasion by increasing mmp 7 production via rac1 erk pathway |
| url | http://dx.doi.org/10.1155/2014/340271 |
| work_keys_str_mv | AT qihongjiang radixinenhancescoloncancercellinvasionbyincreasingmmp7productionviarac1erkpathway AT aixiangwang radixinenhancescoloncancercellinvasionbyincreasingmmp7productionviarac1erkpathway AT yanchen radixinenhancescoloncancercellinvasionbyincreasingmmp7productionviarac1erkpathway |