Unveiling the therapeutic potential of octreotide in treating morphine dependence

Unveiling the therapeutic potential of octreotide in treating morphine dependence

Abstract The potential of octreotide (OCT), an octapeptide synthetic somatostatin agonist, to mitigate addiction, specifically morphine dependence, was evaluated in a comprehensive approach involving behavioral, molecular, histological, and docking studies. OCT decreased addiction-related behaviors...

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Main Authors: Mohammad Shabani, Zeynab Pirmoradi, Moazamehosadat Razavinasab, Amin Hassanshahi, Reyhaneh Naderi, Zahra Esmaili, Mohammad Navid Ebrahimi, Mehran Ilaghi, Mohammad Amin Langarizadeh, Amir Hossain Moqaddari, Leili Rouhi, Meysam Ahmadi-Zeidabadi, Maryam Amiri, Kristi A. Kohlmeier, Sajad Amiri, Hamid Forootanfar, Mohammad Banazadeh
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Octreotide
Addiction
Molecular docking
Rat
Online Access:https://doi.org/10.1038/s41598-025-12761-6
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