Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders
BackgroundIt has been well established that psychiatric disorders are often accompanied by cognitive dysfunction. Previous studies have investigated the verbal fluency task (VFT) for detecting executive function impairment in different psychiatric disorders, but the sensitivity and specificity of th...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1542346/full |
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| author | Fanxi Ding Yiyang Ying Yuqing Jin Xuanru Guo Xuanru Guo You Xu Zhenghe Yu Haiteng Jiang Haiteng Jiang Haiteng Jiang |
| author_facet | Fanxi Ding Yiyang Ying Yuqing Jin Xuanru Guo Xuanru Guo You Xu Zhenghe Yu Haiteng Jiang Haiteng Jiang Haiteng Jiang |
| author_sort | Fanxi Ding |
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| description | BackgroundIt has been well established that psychiatric disorders are often accompanied by cognitive dysfunction. Previous studies have investigated the verbal fluency task (VFT) for detecting executive function impairment in different psychiatric disorders, but the sensitivity and specificity of this task in different psychiatric disorders have not been explored. Furthermore, clarifying the mechanisms underlying variations in executive function impairments across multiple psychiatric disorders will enhance our comprehension of brain activity alternations among these disorders. Therefore, this study combined the VFT and the functional near-infrared spectroscopy (fNIRS) to investigate the neural mechanisms underlying the impairment of executive function across psychiatric disorders including anxiety disorder (AD), sleep disorder (SD) and major depressive disorder (MDD).MethodsTwo hundred and eight participants were enrolled including 52 AD, 52 SD, 52 MDD and 52 healthy controls (HCs). All participants completed the VFT while being monitored using fNIRS to measure changes in brain oxygenated hemoglobin (Oxy-Hb).ResultsOur results demonstrated that MDD, AD and SD exhibited decreased overall connectivity strength, as well as reduced connected networks involving the frontal and temporal regions during the VFT comparing to HC. Furthermore, the MDD group showed a reduction in connected networks, specifically in the left superior temporal gyrus and precentral gyrus, compared to the AD group.ConclusionOur study offers neural evidence that the VFT combined with fNIRS could effectively detect executive function impairment in different psychiatric disorders. |
| format | Article |
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| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-6df456fc3f304a6d98b4a2a204afcbc02025-01-30T14:26:24ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011610.3389/fneur.2025.15423461542346Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disordersFanxi Ding0Yiyang Ying1Yuqing Jin2Xuanru Guo3Xuanru Guo4You Xu5Zhenghe Yu6Haiteng Jiang7Haiteng Jiang8Haiteng Jiang9Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, School of Brain Science and Brain Medicine, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, ChinaThe First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Psychology and Behavioural Sciences, Zhejiang University, Hangzhou, ChinaAffiliated Mental Health Center & Hangzhou Seventh People’s Hospital, School of Brain Science and Brain Medicine, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Psychology and Behavioural Sciences, Zhejiang University, Hangzhou, ChinaAffiliated Mental Health Center & Hangzhou Seventh People’s Hospital, School of Brain Science and Brain Medicine, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, ChinaAffiliated Mental Health Center & Hangzhou Seventh People’s Hospital, School of Brain Science and Brain Medicine, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, ChinaAffiliated Mental Health Center & Hangzhou Seventh People’s Hospital, School of Brain Science and Brain Medicine, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, ChinaMOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou, ChinaNHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, ChinaBackgroundIt has been well established that psychiatric disorders are often accompanied by cognitive dysfunction. Previous studies have investigated the verbal fluency task (VFT) for detecting executive function impairment in different psychiatric disorders, but the sensitivity and specificity of this task in different psychiatric disorders have not been explored. Furthermore, clarifying the mechanisms underlying variations in executive function impairments across multiple psychiatric disorders will enhance our comprehension of brain activity alternations among these disorders. Therefore, this study combined the VFT and the functional near-infrared spectroscopy (fNIRS) to investigate the neural mechanisms underlying the impairment of executive function across psychiatric disorders including anxiety disorder (AD), sleep disorder (SD) and major depressive disorder (MDD).MethodsTwo hundred and eight participants were enrolled including 52 AD, 52 SD, 52 MDD and 52 healthy controls (HCs). All participants completed the VFT while being monitored using fNIRS to measure changes in brain oxygenated hemoglobin (Oxy-Hb).ResultsOur results demonstrated that MDD, AD and SD exhibited decreased overall connectivity strength, as well as reduced connected networks involving the frontal and temporal regions during the VFT comparing to HC. Furthermore, the MDD group showed a reduction in connected networks, specifically in the left superior temporal gyrus and precentral gyrus, compared to the AD group.ConclusionOur study offers neural evidence that the VFT combined with fNIRS could effectively detect executive function impairment in different psychiatric disorders.https://www.frontiersin.org/articles/10.3389/fneur.2025.1542346/fullfNIRSexecutive functionverbal fluency taskfunctional connectivitynetwork-based statistic |
| spellingShingle | Fanxi Ding Yiyang Ying Yuqing Jin Xuanru Guo Xuanru Guo You Xu Zhenghe Yu Haiteng Jiang Haiteng Jiang Haiteng Jiang Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders Frontiers in Neurology fNIRS executive function verbal fluency task functional connectivity network-based statistic |
| title | Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders |
| title_full | Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders |
| title_fullStr | Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders |
| title_full_unstemmed | Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders |
| title_short | Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders |
| title_sort | reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety sleep and major depressive disorders |
| topic | fNIRS executive function verbal fluency task functional connectivity network-based statistic |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1542346/full |
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