Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview
SLE is an autoimmune disease that is not uncommon in Malaysia. In contrast to Malays and Indians, the Chinese seem to be most affected. SLE is characterized by deficiency of body's immune response that leads to production of autoantibodies and failure of immune complex clearance. This minirevie...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/963730 |
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| author | Hwa Chia Chai Maude Elvira Phipps Kek Heng Chua |
| author_facet | Hwa Chia Chai Maude Elvira Phipps Kek Heng Chua |
| author_sort | Hwa Chia Chai |
| collection | DOAJ |
| description | SLE is an autoimmune disease that is not uncommon in Malaysia. In contrast to Malays and Indians, the Chinese seem to be most affected. SLE is characterized by deficiency of body's immune response that leads to production of autoantibodies and failure of immune complex clearance. This minireview attempts to summarize the association of several candidate genes with risk for SLE in the Malaysian population and discuss the genetic heterogeneity that exists locally in Asians and in comparison with SLE in Caucasians. Several groups of researchers have been actively investigating genes that are associated with SLE susceptibility in the Malaysian population by screening possible reported candidate genes across the SLE patients and healthy controls. These candidate genes include MHC genes and genes encoding complement components, TNF, FcγR, T-cell receptors, and interleukins. However, most of the polymorphisms investigated in these genes did not show significant associations with susceptibility to SLE in the Malaysian scenario, except for those occurring in MHC genes and genes coding for TNF-α, IL-1β, IL-1RN, and IL-6. |
| format | Article |
| id | doaj-art-6dee3ec581e04441b628fa7f870baa79 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-6dee3ec581e04441b628fa7f870baa792025-02-03T01:12:31ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/963730963730Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A MinireviewHwa Chia Chai0Maude Elvira Phipps1Kek Heng Chua2Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Sunway Campus, 46150 Selangor Darul Ehsan, MalaysiaJeffrey Cheah School of Medicine and Health Sciences, Monash University, Sunway Campus, 46150 Selangor Darul Ehsan, MalaysiaDepartment of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaSLE is an autoimmune disease that is not uncommon in Malaysia. In contrast to Malays and Indians, the Chinese seem to be most affected. SLE is characterized by deficiency of body's immune response that leads to production of autoantibodies and failure of immune complex clearance. This minireview attempts to summarize the association of several candidate genes with risk for SLE in the Malaysian population and discuss the genetic heterogeneity that exists locally in Asians and in comparison with SLE in Caucasians. Several groups of researchers have been actively investigating genes that are associated with SLE susceptibility in the Malaysian population by screening possible reported candidate genes across the SLE patients and healthy controls. These candidate genes include MHC genes and genes encoding complement components, TNF, FcγR, T-cell receptors, and interleukins. However, most of the polymorphisms investigated in these genes did not show significant associations with susceptibility to SLE in the Malaysian scenario, except for those occurring in MHC genes and genes coding for TNF-α, IL-1β, IL-1RN, and IL-6.http://dx.doi.org/10.1155/2012/963730 |
| spellingShingle | Hwa Chia Chai Maude Elvira Phipps Kek Heng Chua Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview Clinical and Developmental Immunology |
| title | Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview |
| title_full | Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview |
| title_fullStr | Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview |
| title_full_unstemmed | Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview |
| title_short | Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview |
| title_sort | genetic risk factors of systemic lupus erythematosus in the malaysian population a minireview |
| url | http://dx.doi.org/10.1155/2012/963730 |
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