Hepatitis B prevalence in an endemic area of hepatitis C virus: A population-based study implicated in hepatitis elimination in Thailand
Chronic hepatitis B (HBV) and C (HCV) are major health challenges in Thailand, with Phetchabun province, a known HCV-endemic area, being a key target for elimination efforts. This study aimed to assess HBV prevalence and identify associated risk factors in this province. Data was collected from thre...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Journal of Virus Eradication |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2055664024001924 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585132658130944 |
|---|---|
| author | Nawarat Posuwan Rujipat Wasitthankasem Napaporn Pimsing Wijittra Phaengkha Saranya Ngamnimit Preeyaporn Vichaiwattana Sirapa Klinfueng Maneerat Raksayod Yong Poovorawan |
| author_facet | Nawarat Posuwan Rujipat Wasitthankasem Napaporn Pimsing Wijittra Phaengkha Saranya Ngamnimit Preeyaporn Vichaiwattana Sirapa Klinfueng Maneerat Raksayod Yong Poovorawan |
| author_sort | Nawarat Posuwan |
| collection | DOAJ |
| description | Chronic hepatitis B (HBV) and C (HCV) are major health challenges in Thailand, with Phetchabun province, a known HCV-endemic area, being a key target for elimination efforts. This study aimed to assess HBV prevalence and identify associated risk factors in this province. Data was collected from three cross-sectional population studies: (1) adults in 2015 (n = 1,667, age 30–64 years), (2) young adults in 2017 (n = 1,453, age 18–30 years), both from high HCV-endemic districts, and (3) a province-wide study in 2018 (n = 4,769, age 35–64 years). Plasma samples were tested for HBsAg using the ARCHITECT assay. Results showed HBsAg seropositivity in 3.1 % of young adults in high-endemic districts, with significant associations with age, education, injecting drug use, and MSM behavior. Among adults, HBsAg prevalence was 5.9 %, linked to age and family liver disease history. Province-wide, 6.3 % of adults tested positive, with factors like gender and history of blood donation playing significant roles. Notably, age and blood donation were protective factors against HBV in adults. Analysis revealed a moderate HBV prevalence in those born before Thailand Expanded Program on Immunization (EPI) program, while those born after had rates below 1 %. The findings emphasize distinct HBV transmission patterns in different age groups, influenced by social and behavioral shifts. This knowledge is crucial for effective hepatitis elimination strategies in the Phetchabun province and nationwide. |
| format | Article |
| id | doaj-art-6de80e7675914a708587d74e256e7435 |
| institution | Kabale University |
| issn | 2055-6640 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Virus Eradication |
| spelling | doaj-art-6de80e7675914a708587d74e256e74352025-01-27T04:21:50ZengElsevierJournal of Virus Eradication2055-66402024-12-01104100577Hepatitis B prevalence in an endemic area of hepatitis C virus: A population-based study implicated in hepatitis elimination in ThailandNawarat Posuwan0Rujipat Wasitthankasem1Napaporn Pimsing2Wijittra Phaengkha3Saranya Ngamnimit4Preeyaporn Vichaiwattana5Sirapa Klinfueng6Maneerat Raksayod7Yong Poovorawan8Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Chulahorn International College of Medicine, Thammasat University, Rangsit Campus, Patum Thani, ThailandNational Biobank of Thailand, National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Patum Thani, ThailandPhetchabun Provincial Public Health Office, Phetchabun, ThailandNam Nao Hospital, Nam Nao District, Phetchabun, ThailandPhetchabun Provincial Public Health Office, Phetchabun, ThailandCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandNational Biobank of Thailand, National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Patum Thani, ThailandCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Corresponding author.Chronic hepatitis B (HBV) and C (HCV) are major health challenges in Thailand, with Phetchabun province, a known HCV-endemic area, being a key target for elimination efforts. This study aimed to assess HBV prevalence and identify associated risk factors in this province. Data was collected from three cross-sectional population studies: (1) adults in 2015 (n = 1,667, age 30–64 years), (2) young adults in 2017 (n = 1,453, age 18–30 years), both from high HCV-endemic districts, and (3) a province-wide study in 2018 (n = 4,769, age 35–64 years). Plasma samples were tested for HBsAg using the ARCHITECT assay. Results showed HBsAg seropositivity in 3.1 % of young adults in high-endemic districts, with significant associations with age, education, injecting drug use, and MSM behavior. Among adults, HBsAg prevalence was 5.9 %, linked to age and family liver disease history. Province-wide, 6.3 % of adults tested positive, with factors like gender and history of blood donation playing significant roles. Notably, age and blood donation were protective factors against HBV in adults. Analysis revealed a moderate HBV prevalence in those born before Thailand Expanded Program on Immunization (EPI) program, while those born after had rates below 1 %. The findings emphasize distinct HBV transmission patterns in different age groups, influenced by social and behavioral shifts. This knowledge is crucial for effective hepatitis elimination strategies in the Phetchabun province and nationwide.http://www.sciencedirect.com/science/article/pii/S2055664024001924PrevalenceHepatitis B virus (HBV)Highest HCV-EndemicThailand |
| spellingShingle | Nawarat Posuwan Rujipat Wasitthankasem Napaporn Pimsing Wijittra Phaengkha Saranya Ngamnimit Preeyaporn Vichaiwattana Sirapa Klinfueng Maneerat Raksayod Yong Poovorawan Hepatitis B prevalence in an endemic area of hepatitis C virus: A population-based study implicated in hepatitis elimination in Thailand Journal of Virus Eradication Prevalence Hepatitis B virus (HBV) Highest HCV-Endemic Thailand |
| title | Hepatitis B prevalence in an endemic area of hepatitis C virus: A population-based study implicated in hepatitis elimination in Thailand |
| title_full | Hepatitis B prevalence in an endemic area of hepatitis C virus: A population-based study implicated in hepatitis elimination in Thailand |
| title_fullStr | Hepatitis B prevalence in an endemic area of hepatitis C virus: A population-based study implicated in hepatitis elimination in Thailand |
| title_full_unstemmed | Hepatitis B prevalence in an endemic area of hepatitis C virus: A population-based study implicated in hepatitis elimination in Thailand |
| title_short | Hepatitis B prevalence in an endemic area of hepatitis C virus: A population-based study implicated in hepatitis elimination in Thailand |
| title_sort | hepatitis b prevalence in an endemic area of hepatitis c virus a population based study implicated in hepatitis elimination in thailand |
| topic | Prevalence Hepatitis B virus (HBV) Highest HCV-Endemic Thailand |
| url | http://www.sciencedirect.com/science/article/pii/S2055664024001924 |
| work_keys_str_mv | AT nawaratposuwan hepatitisbprevalenceinanendemicareaofhepatitiscvirusapopulationbasedstudyimplicatedinhepatitiseliminationinthailand AT rujipatwasitthankasem hepatitisbprevalenceinanendemicareaofhepatitiscvirusapopulationbasedstudyimplicatedinhepatitiseliminationinthailand AT napapornpimsing hepatitisbprevalenceinanendemicareaofhepatitiscvirusapopulationbasedstudyimplicatedinhepatitiseliminationinthailand AT wijittraphaengkha hepatitisbprevalenceinanendemicareaofhepatitiscvirusapopulationbasedstudyimplicatedinhepatitiseliminationinthailand AT saranyangamnimit hepatitisbprevalenceinanendemicareaofhepatitiscvirusapopulationbasedstudyimplicatedinhepatitiseliminationinthailand AT preeyapornvichaiwattana hepatitisbprevalenceinanendemicareaofhepatitiscvirusapopulationbasedstudyimplicatedinhepatitiseliminationinthailand AT sirapaklinfueng hepatitisbprevalenceinanendemicareaofhepatitiscvirusapopulationbasedstudyimplicatedinhepatitiseliminationinthailand AT maneeratraksayod hepatitisbprevalenceinanendemicareaofhepatitiscvirusapopulationbasedstudyimplicatedinhepatitiseliminationinthailand AT yongpoovorawan hepatitisbprevalenceinanendemicareaofhepatitiscvirusapopulationbasedstudyimplicatedinhepatitiseliminationinthailand |