The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia
Background: During aging, there is a progressive impairment of immune cell function that triggers the production of pro-inflammatory cytokines causing the so-called “inflammaging”. Frailty represents a condition of increased vulnerability to stresses and reduced homeostatic reserve reflecting not on...
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Elsevier
2025-03-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556525000208 |
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| author | Beatrice Arosio Paolo Dionigi Rossi Evelyn Ferri Ernesto Consorti Simona Ciccone Tiziano Angelo Lucchi Nicola Montano |
| author_facet | Beatrice Arosio Paolo Dionigi Rossi Evelyn Ferri Ernesto Consorti Simona Ciccone Tiziano Angelo Lucchi Nicola Montano |
| author_sort | Beatrice Arosio |
| collection | DOAJ |
| description | Background: During aging, there is a progressive impairment of immune cell function that triggers the production of pro-inflammatory cytokines causing the so-called “inflammaging”. Frailty represents a condition of increased vulnerability to stresses and reduced homeostatic reserve reflecting not only health status but also biological age. In older subjects without dementia, we showed that markers of inflammaging were differently associated with chronological age than with frailty. This study analysed the same markers in older people with cognitive decline and/or dementia. Methods: The cohort consisted of 776 community-dwelling older people: 235 patients with mild cognitive impairment, 63 with Alzheimer's disease (AD), 175 with mixed dementia (MD), and 303 subjects without cognitive decline. Plasma concentrations of inflammatory cytokines and peripheral markers of neuroinflammation were analysed by next-generation ELISA. Results: After adjustment for age, sex, frailty, education and Apolipoprotein E genotype, only interleukin-10, interleukin-1β, and neurofilament light chain were associated with the risk for AD and MD. Moreover, interleukin-6 showed a weak association only with AD. Conclusions: Our data showed similar associations between AD and MD, supporting the concept that late-onset dementia is a complex outcome of aging, intimately linked to the individual's health status as well as frailty. |
| format | Article |
| id | doaj-art-6de07f8e204c4fdb86b19ebecd4e714a |
| institution | Kabale University |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-6de07f8e204c4fdb86b19ebecd4e714a2025-01-31T05:10:09ZengElsevierExperimental Gerontology1873-68152025-03-01201112692The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementiaBeatrice Arosio0Paolo Dionigi Rossi1Evelyn Ferri2Ernesto Consorti3Simona Ciccone4Tiziano Angelo Lucchi5Nicola Montano6Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023–2027, University of Milan, 20122 Milan, Italy; Corresponding author.San Leopoldo Mandic Hospital, Largo Mandic 1, 23807 Merate, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, ItalyFellowship in Geriatrics and Gerontology, University of Milan, Via Festa del Perdono 7, 20122 Milan, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023–2027, University of Milan, 20122 Milan, Italy; Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, ItalyBackground: During aging, there is a progressive impairment of immune cell function that triggers the production of pro-inflammatory cytokines causing the so-called “inflammaging”. Frailty represents a condition of increased vulnerability to stresses and reduced homeostatic reserve reflecting not only health status but also biological age. In older subjects without dementia, we showed that markers of inflammaging were differently associated with chronological age than with frailty. This study analysed the same markers in older people with cognitive decline and/or dementia. Methods: The cohort consisted of 776 community-dwelling older people: 235 patients with mild cognitive impairment, 63 with Alzheimer's disease (AD), 175 with mixed dementia (MD), and 303 subjects without cognitive decline. Plasma concentrations of inflammatory cytokines and peripheral markers of neuroinflammation were analysed by next-generation ELISA. Results: After adjustment for age, sex, frailty, education and Apolipoprotein E genotype, only interleukin-10, interleukin-1β, and neurofilament light chain were associated with the risk for AD and MD. Moreover, interleukin-6 showed a weak association only with AD. Conclusions: Our data showed similar associations between AD and MD, supporting the concept that late-onset dementia is a complex outcome of aging, intimately linked to the individual's health status as well as frailty.http://www.sciencedirect.com/science/article/pii/S0531556525000208InflammagingFrailtyAlzheimer's diseaseMixed dementiaBiomarkers |
| spellingShingle | Beatrice Arosio Paolo Dionigi Rossi Evelyn Ferri Ernesto Consorti Simona Ciccone Tiziano Angelo Lucchi Nicola Montano The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia Experimental Gerontology Inflammaging Frailty Alzheimer's disease Mixed dementia Biomarkers |
| title | The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia |
| title_full | The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia |
| title_fullStr | The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia |
| title_full_unstemmed | The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia |
| title_short | The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia |
| title_sort | inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia |
| topic | Inflammaging Frailty Alzheimer's disease Mixed dementia Biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S0531556525000208 |
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