The single-cell transcription reveals the aberrant differentiation trajectory of chondrocytes in the intervertebral disc for congenital scoliosis

The single-cell transcription reveals the aberrant differentiation trajectory of chondrocytes in the intervertebral disc for congenital scoliosis

Summary: Cartilage endplate (CEP) in the intervertebral disc (IVD) contributes to vertebral level asymmetrically in congenital scoliosis (CS). However, the cellular compositions of CEP and the subsequent alteration of cellular environment in its neighboring annulus fibrosus and nucleus pulposus rema...

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Bibliographic Details
Main Authors: Junfeng Wang, Haodong Li, Dong Fu, Yiming Zheng, Chuang Qian, Lin Li, Maoxiang Qian, Dahui Wang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
pathophysiology
transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225008697
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