Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity
To assess whether PAF could be involved in the gentamicin-induced nephrotoxicity, we have studied the effect of PAF antagonist BN-52021 on renal function in rats after gentamicin (GENTA) treatment. Experiments were completed in 21 Wistar rats divided into three groups: group GENTA was injected with...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S096293519200005X |
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| _version_ | 1832563088474243072 |
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| author | A. Rodriguez-Barbero E. Bosque L. Rivas-Cabaero M. Arévalo J. M. López-Novoa |
| author_facet | A. Rodriguez-Barbero E. Bosque L. Rivas-Cabaero M. Arévalo J. M. López-Novoa |
| author_sort | A. Rodriguez-Barbero |
| collection | DOAJ |
| description | To assess whether PAF could be involved in the gentamicin-induced nephrotoxicity, we have studied the effect of PAF antagonist BN-52021 on renal function in rats after gentamicin (GENTA) treatment. Experiments were completed in 21 Wistar rats divided into three groups: group GENTA was injected with gentamicin 100 mg kg−1 body wt/day s.c. for 6 days. Group GENTA + BN received gentamicin and BN-52021 i.p. 5 mg kg−1 body wt/day. A third group served as control. Rats were placed in meta-bolic cages and plasma creatinine and creatinine clearance were measured daily. GENTA group showed a progressive increase in plasma creatinine, a drop in creatinine clearance and an increase in urinary excretion of N-acetyl-β-D-glucosaminidase and alkaline phosphatase. GENTA + BN group showed a lesser change in plasma creatinine and a creatinine clearance, but no difference with GENTA group in urinary excretion of NAG and AP were observed. Histological examination revealed a massive cortical tubular necrosis in rats treated with gentamicin, whereas in BN-52021 injected animals tubular damage was markedly attenuated. The present results suggest a role for PAF in the gentamicininduced nephro-toxicity. |
| format | Article |
| id | doaj-art-6da62b0aedac4c6d9b8d0ca5611869c7 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6da62b0aedac4c6d9b8d0ca5611869c72025-02-03T01:20:56ZengWileyMediators of Inflammation0962-93511466-18611992-01-0111232610.1155/S096293519200005XEffect of platelet activating factor antagonist treatment on gentamicin nephrotoxicityA. Rodriguez-Barbero0E. Bosque1L. Rivas-Cabaero2M. Arévalo3J. M. López-Novoa4Departmento de Fisiologia y Farmacologia, Facultad de Medicina, Universidad de Salamanca, Avda, Campo Charro s/n, salamanca 37007, SpainDepartmento de Fisiologia y Farmacologia, Facultad de Medicina, Universidad de Salamanca, Avda, Campo Charro s/n, salamanca 37007, SpainDepartmento de Fisiologia y Farmacologia, Facultad de Medicina, Universidad de Salamanca, Avda, Campo Charro s/n, salamanca 37007, SpainDepartmento de Anatomia e Histologia, Facultad de Medicina, Universidad de Salamanca, Avda, Campo Charro s/n, salamanca 37007, SpainDepartmento de Fisiologia y Farmacologia, Facultad de Medicina, Universidad de Salamanca, Avda, Campo Charro s/n, salamanca 37007, SpainTo assess whether PAF could be involved in the gentamicin-induced nephrotoxicity, we have studied the effect of PAF antagonist BN-52021 on renal function in rats after gentamicin (GENTA) treatment. Experiments were completed in 21 Wistar rats divided into three groups: group GENTA was injected with gentamicin 100 mg kg−1 body wt/day s.c. for 6 days. Group GENTA + BN received gentamicin and BN-52021 i.p. 5 mg kg−1 body wt/day. A third group served as control. Rats were placed in meta-bolic cages and plasma creatinine and creatinine clearance were measured daily. GENTA group showed a progressive increase in plasma creatinine, a drop in creatinine clearance and an increase in urinary excretion of N-acetyl-β-D-glucosaminidase and alkaline phosphatase. GENTA + BN group showed a lesser change in plasma creatinine and a creatinine clearance, but no difference with GENTA group in urinary excretion of NAG and AP were observed. Histological examination revealed a massive cortical tubular necrosis in rats treated with gentamicin, whereas in BN-52021 injected animals tubular damage was markedly attenuated. The present results suggest a role for PAF in the gentamicininduced nephro-toxicity.http://dx.doi.org/10.1155/S096293519200005X |
| spellingShingle | A. Rodriguez-Barbero E. Bosque L. Rivas-Cabaero M. Arévalo J. M. López-Novoa Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity Mediators of Inflammation |
| title | Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
| title_full | Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
| title_fullStr | Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
| title_full_unstemmed | Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
| title_short | Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
| title_sort | effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity |
| url | http://dx.doi.org/10.1155/S096293519200005X |
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