Successfully Treated Norovirus- and Sapovirus-Associated Diarrhea in Three Renal Transplant Patients
Objectives. To examine the burden of norovirus- and sapovirus-related diarrhea in renal transplant patients and to propose the use of nitazoxanide as a therapeutic option for treatment. Methods. We reviewed three renal transplant patients with viral diarrhea requiring hospitalization due to acute re...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2018/6846873 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554290454986752 |
|---|---|
| author | Noha Ghusson Gustavo Vasquez |
| author_facet | Noha Ghusson Gustavo Vasquez |
| author_sort | Noha Ghusson |
| collection | DOAJ |
| description | Objectives. To examine the burden of norovirus- and sapovirus-related diarrhea in renal transplant patients and to propose the use of nitazoxanide as a therapeutic option for treatment. Methods. We reviewed three renal transplant patients with viral diarrhea requiring hospitalization due to acute renal failure and signs of graft rejection. All three patients were treated with nitazoxanide. We examined their clinical courses after therapy and compared time to resolution of symptoms and viral shedding. Results. In all three renal transplant patients, improvement of diarrheal illness was witnessed within one week of nitazoxanide initiation. Conclusions. Infectious diarrhea remains an underestimated yet significant cause of morbidity in solid organ transplant patients. Norovirus and sapovirus are often responsible for this presentation. Nitazoxanide was used as a treatment modality with success in reduction of symptoms, decreased duration of illness, and cessation of viral shedding. |
| format | Article |
| id | doaj-art-6da224048e27457ababd67b63f9e3962 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-6da224048e27457ababd67b63f9e39622025-02-03T05:51:55ZengWileyCase Reports in Infectious Diseases2090-66252090-66332018-01-01201810.1155/2018/68468736846873Successfully Treated Norovirus- and Sapovirus-Associated Diarrhea in Three Renal Transplant PatientsNoha Ghusson0Gustavo Vasquez1Sidney Kimmel Medical College at Thomas Jefferson University, Division of Infectious Diseases, 1015 Chestnut Street, Suite 1020, Philadelphia, PA 19107, USASidney Kimmel Medical College at Thomas Jefferson University, Division of Infectious Diseases, 1015 Chestnut Street, Suite 1020, Philadelphia, PA 19107, USAObjectives. To examine the burden of norovirus- and sapovirus-related diarrhea in renal transplant patients and to propose the use of nitazoxanide as a therapeutic option for treatment. Methods. We reviewed three renal transplant patients with viral diarrhea requiring hospitalization due to acute renal failure and signs of graft rejection. All three patients were treated with nitazoxanide. We examined their clinical courses after therapy and compared time to resolution of symptoms and viral shedding. Results. In all three renal transplant patients, improvement of diarrheal illness was witnessed within one week of nitazoxanide initiation. Conclusions. Infectious diarrhea remains an underestimated yet significant cause of morbidity in solid organ transplant patients. Norovirus and sapovirus are often responsible for this presentation. Nitazoxanide was used as a treatment modality with success in reduction of symptoms, decreased duration of illness, and cessation of viral shedding.http://dx.doi.org/10.1155/2018/6846873 |
| spellingShingle | Noha Ghusson Gustavo Vasquez Successfully Treated Norovirus- and Sapovirus-Associated Diarrhea in Three Renal Transplant Patients Case Reports in Infectious Diseases |
| title | Successfully Treated Norovirus- and Sapovirus-Associated Diarrhea in Three Renal Transplant Patients |
| title_full | Successfully Treated Norovirus- and Sapovirus-Associated Diarrhea in Three Renal Transplant Patients |
| title_fullStr | Successfully Treated Norovirus- and Sapovirus-Associated Diarrhea in Three Renal Transplant Patients |
| title_full_unstemmed | Successfully Treated Norovirus- and Sapovirus-Associated Diarrhea in Three Renal Transplant Patients |
| title_short | Successfully Treated Norovirus- and Sapovirus-Associated Diarrhea in Three Renal Transplant Patients |
| title_sort | successfully treated norovirus and sapovirus associated diarrhea in three renal transplant patients |
| url | http://dx.doi.org/10.1155/2018/6846873 |
| work_keys_str_mv | AT nohaghusson successfullytreatednorovirusandsapovirusassociateddiarrheainthreerenaltransplantpatients AT gustavovasquez successfullytreatednorovirusandsapovirusassociateddiarrheainthreerenaltransplantpatients |