Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease
The characteristic brain pathology and motor and nonmotor symptoms of Parkinson’s disease (PD) are well established. However, the details regarding the causes of the disease and its course are much less clear. Animal models have significantly enriched our current understanding of the progression of...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2017/9349487 |
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| author | Dongping Huang Jing Xu Jinghui Wang Jiabin Tong Xiaochen Bai Heng Li Zishan Wang Yulu Huang Yufei Wu Mei Yu Fang Huang |
| author_facet | Dongping Huang Jing Xu Jinghui Wang Jiabin Tong Xiaochen Bai Heng Li Zishan Wang Yulu Huang Yufei Wu Mei Yu Fang Huang |
| author_sort | Dongping Huang |
| collection | DOAJ |
| description | The characteristic brain pathology and motor and nonmotor symptoms of Parkinson’s disease (PD) are well established. However, the details regarding the causes of the disease and its course are much less clear. Animal models have significantly enriched our current understanding of the progression of this disease. Among various neurotoxin-based models of PD, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model is the most commonly studied model. Here, we provide an overview of the dynamic changes in the nigrostriatal pathway in the MPTP mouse model of PD. Pathophysiological events, such as reductions in the striatal dopamine (DA) concentrations and levels of the tyrosine hydroxylase (TH) protein, depletion of TH-positive nerve fibers, a decrease in the number of TH-positive neurons in the substantia nigra pars compacta (SNpc), and glial activation, are addressed. This article will assist with the development of interventions or therapeutic strategies for PD. |
| format | Article |
| id | doaj-art-6d9a504b115449cca586a39ca6a0139b |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-6d9a504b115449cca586a39ca6a0139b2025-02-03T06:44:38ZengWileyParkinson's Disease2090-80832042-00802017-01-01201710.1155/2017/93494879349487Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s DiseaseDongping Huang0Jing Xu1Jinghui Wang2Jiabin Tong3Xiaochen Bai4Heng Li5Zishan Wang6Yulu Huang7Yufei Wu8Mei Yu9Fang Huang10The State Key Laboratory of Medical Neurobiology, The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, ChinaSchool of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, ChinaThe State Key Laboratory of Medical Neurobiology, The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, ChinaThe State Key Laboratory of Medical Neurobiology, The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, ChinaThe State Key Laboratory of Medical Neurobiology, The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, ChinaThe State Key Laboratory of Medical Neurobiology, The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, ChinaThe State Key Laboratory of Medical Neurobiology, The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, ChinaSchool of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Shanghai 200032, ChinaSchool of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Shanghai 200032, ChinaThe State Key Laboratory of Medical Neurobiology, The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, ChinaThe State Key Laboratory of Medical Neurobiology, The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, ChinaThe characteristic brain pathology and motor and nonmotor symptoms of Parkinson’s disease (PD) are well established. However, the details regarding the causes of the disease and its course are much less clear. Animal models have significantly enriched our current understanding of the progression of this disease. Among various neurotoxin-based models of PD, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model is the most commonly studied model. Here, we provide an overview of the dynamic changes in the nigrostriatal pathway in the MPTP mouse model of PD. Pathophysiological events, such as reductions in the striatal dopamine (DA) concentrations and levels of the tyrosine hydroxylase (TH) protein, depletion of TH-positive nerve fibers, a decrease in the number of TH-positive neurons in the substantia nigra pars compacta (SNpc), and glial activation, are addressed. This article will assist with the development of interventions or therapeutic strategies for PD.http://dx.doi.org/10.1155/2017/9349487 |
| spellingShingle | Dongping Huang Jing Xu Jinghui Wang Jiabin Tong Xiaochen Bai Heng Li Zishan Wang Yulu Huang Yufei Wu Mei Yu Fang Huang Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease Parkinson's Disease |
| title | Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease |
| title_full | Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease |
| title_fullStr | Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease |
| title_full_unstemmed | Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease |
| title_short | Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease |
| title_sort | dynamic changes in the nigrostriatal pathway in the mptp mouse model of parkinson s disease |
| url | http://dx.doi.org/10.1155/2017/9349487 |
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