Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review
ABSTRACT: Brain energy homeostasis is a vital physiological function in maintaining a balanced internal metabolic environment. The impairment of energy homeostasis is recognized as a key pathophysiological basis for brain metabolic disorders and related neurodegenerative diseases. Dendrobium species...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000812 |
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| author | Feixuan Wang Jingqiong Wan Yangzhen Liao Shangyu Liu Yuan Wei Zhen Ouyang |
| author_facet | Feixuan Wang Jingqiong Wan Yangzhen Liao Shangyu Liu Yuan Wei Zhen Ouyang |
| author_sort | Feixuan Wang |
| collection | DOAJ |
| description | ABSTRACT: Brain energy homeostasis is a vital physiological function in maintaining a balanced internal metabolic environment. The impairment of energy homeostasis is recognized as a key pathophysiological basis for brain metabolic disorders and related neurodegenerative diseases. Dendrobium species ('Shihu' in Chinese) such as D. officinale, D. huoshanense, D. nobile, D. chrysanthum, D. loddigesii, D. moniliforme, D. gratiosissimum, D. candidum and D. caulis are widely used as traditional Chinese medicines/nutraceuticals to control and treat neurodegenerative disorders. These dietary herbs and their derived compounds possess a variety of biological properties, such as suppression of oxidative stress and neuroinflammation, regulation of energy homeostasis mainly through improving brain mitochondria function, insulin signaling and lipid metabolism. Furthermore, they reduce neurotoxicity, alleviate brain injury and neuropathy, and prevent neurodegenerative conditions including stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease in humans and/or rodents. Moreover, the nutraceuticals from Dendrobium species promote gut health and aid digestion, which appear to be associated with beneficial effects on brain energy homeostasis. Based on the above-mentioned health benefits associated with Dendrobium species, this work reviews their nutraceutical role in neurodegenerative disorders and further suggests the need to elucidate mechanisms of the underlying molecular actions. |
| format | Article |
| id | doaj-art-6d90c87950854cf4ad012d9469549edb |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-6d90c87950854cf4ad012d9469549edb2025-02-03T02:42:15ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112621512174Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a reviewFeixuan Wang0Jingqiong Wan1Yangzhen Liao2Shangyu Liu3Yuan Wei4Zhen Ouyang5School of Pharmacy, Jiangsu University, Zhenjiang 212013, China; Nanjing Institute of Product Quality Inspection, Nanjing 210019, ChinaSchool of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaSchool of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaSchool of Pharmacy, Jiangsu University, Zhenjiang 212013, China; Corresponding author at: School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.ABSTRACT: Brain energy homeostasis is a vital physiological function in maintaining a balanced internal metabolic environment. The impairment of energy homeostasis is recognized as a key pathophysiological basis for brain metabolic disorders and related neurodegenerative diseases. Dendrobium species ('Shihu' in Chinese) such as D. officinale, D. huoshanense, D. nobile, D. chrysanthum, D. loddigesii, D. moniliforme, D. gratiosissimum, D. candidum and D. caulis are widely used as traditional Chinese medicines/nutraceuticals to control and treat neurodegenerative disorders. These dietary herbs and their derived compounds possess a variety of biological properties, such as suppression of oxidative stress and neuroinflammation, regulation of energy homeostasis mainly through improving brain mitochondria function, insulin signaling and lipid metabolism. Furthermore, they reduce neurotoxicity, alleviate brain injury and neuropathy, and prevent neurodegenerative conditions including stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease in humans and/or rodents. Moreover, the nutraceuticals from Dendrobium species promote gut health and aid digestion, which appear to be associated with beneficial effects on brain energy homeostasis. Based on the above-mentioned health benefits associated with Dendrobium species, this work reviews their nutraceutical role in neurodegenerative disorders and further suggests the need to elucidate mechanisms of the underlying molecular actions.http://www.sciencedirect.com/science/article/pii/S2213453023000812Dendrobium speciesNutraceutical roleEnergy homeostasisNeurodegenerative diseases |
| spellingShingle | Feixuan Wang Jingqiong Wan Yangzhen Liao Shangyu Liu Yuan Wei Zhen Ouyang Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review Food Science and Human Wellness Dendrobium species Nutraceutical role Energy homeostasis Neurodegenerative diseases |
| title | Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review |
| title_full | Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review |
| title_fullStr | Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review |
| title_full_unstemmed | Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review |
| title_short | Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review |
| title_sort | dendrobium species regulate energy homeostasis in neurodegenerative diseases a review |
| topic | Dendrobium species Nutraceutical role Energy homeostasis Neurodegenerative diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000812 |
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