Cytokines as Early Markers of Colorectal Anastomotic Leakage: A Systematic Review and Meta-Analysis
Purpose. Colorectal anastomotic leakage (CAL) is one of the most severe complications after colorectal surgery. This meta-analysis evaluates whether systemic or peritoneal inflammatory cytokines may contribute to early detection of CAL. Methods. Systematic literature search was performed in the ackn...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/3786418 |
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| author | Cloë L. Sparreboom Zhouqiao Wu Adem Dereci Geesien S. A. Boersema Anand G. Menon Jiafu Ji Gert-Jan Kleinrensink Johan F. Lange |
| author_facet | Cloë L. Sparreboom Zhouqiao Wu Adem Dereci Geesien S. A. Boersema Anand G. Menon Jiafu Ji Gert-Jan Kleinrensink Johan F. Lange |
| author_sort | Cloë L. Sparreboom |
| collection | DOAJ |
| description | Purpose. Colorectal anastomotic leakage (CAL) is one of the most severe complications after colorectal surgery. This meta-analysis evaluates whether systemic or peritoneal inflammatory cytokines may contribute to early detection of CAL. Methods. Systematic literature search was performed in the acknowledged medical databases according to the PRISMA guidelines to identify studies evaluating systemic and peritoneal levels of TNF, IL-1β, IL-6, and IL-10 for early detection of CAL. Means and standard deviations of systemic and peritoneal cytokine levels were extracted, respectively, for patients with and without CAL. The meta-analysis of the mean differences was carried out for each postoperative day using Review Manager. Results. Seven articles were included. The meta-analysis was performed with 5 articles evaluating peritoneal cytokine levels. Peritoneal levels of IL-6 were significantly higher in patients with CAL compared to patients without CAL on postoperative days 1, 2, and 3 (P<0.05). Similar results were found for peritoneal levels of TNF but on postoperative days 3, 4, and 5 (P<0.05). The articles regarding systemic cytokine levels did not report any significant difference accordingly. Conclusion. Increased postoperative levels of peritoneal IL-6 and TNF are significantly associated with CAL and may contribute to its early detection. |
| format | Article |
| id | doaj-art-6d85795cdd51454f82d12d03139e6a99 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-6d85795cdd51454f82d12d03139e6a992025-02-03T01:33:20ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/37864183786418Cytokines as Early Markers of Colorectal Anastomotic Leakage: A Systematic Review and Meta-AnalysisCloë L. Sparreboom0Zhouqiao Wu1Adem Dereci2Geesien S. A. Boersema3Anand G. Menon4Jiafu Ji5Gert-Jan Kleinrensink6Johan F. Lange7Department of Surgery, Erasmus University Medical Center, 3015 CN Rotterdam, NetherlandsDepartment of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, ChinaDepartment of Surgery, Erasmus University Medical Center, 3015 CN Rotterdam, NetherlandsDepartment of Surgery, Erasmus University Medical Center, 3015 CN Rotterdam, NetherlandsDepartment of Surgery, Havenziekenhuis Rotterdam, 3011 TD Rotterdam, NetherlandsDepartment of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, ChinaDepartment of Neuroscience, Erasmus University Medical Center, 3015 CN Rotterdam, NetherlandsDepartment of Surgery, Erasmus University Medical Center, 3015 CN Rotterdam, NetherlandsPurpose. Colorectal anastomotic leakage (CAL) is one of the most severe complications after colorectal surgery. This meta-analysis evaluates whether systemic or peritoneal inflammatory cytokines may contribute to early detection of CAL. Methods. Systematic literature search was performed in the acknowledged medical databases according to the PRISMA guidelines to identify studies evaluating systemic and peritoneal levels of TNF, IL-1β, IL-6, and IL-10 for early detection of CAL. Means and standard deviations of systemic and peritoneal cytokine levels were extracted, respectively, for patients with and without CAL. The meta-analysis of the mean differences was carried out for each postoperative day using Review Manager. Results. Seven articles were included. The meta-analysis was performed with 5 articles evaluating peritoneal cytokine levels. Peritoneal levels of IL-6 were significantly higher in patients with CAL compared to patients without CAL on postoperative days 1, 2, and 3 (P<0.05). Similar results were found for peritoneal levels of TNF but on postoperative days 3, 4, and 5 (P<0.05). The articles regarding systemic cytokine levels did not report any significant difference accordingly. Conclusion. Increased postoperative levels of peritoneal IL-6 and TNF are significantly associated with CAL and may contribute to its early detection.http://dx.doi.org/10.1155/2016/3786418 |
| spellingShingle | Cloë L. Sparreboom Zhouqiao Wu Adem Dereci Geesien S. A. Boersema Anand G. Menon Jiafu Ji Gert-Jan Kleinrensink Johan F. Lange Cytokines as Early Markers of Colorectal Anastomotic Leakage: A Systematic Review and Meta-Analysis Gastroenterology Research and Practice |
| title | Cytokines as Early Markers of Colorectal Anastomotic Leakage: A Systematic Review and Meta-Analysis |
| title_full | Cytokines as Early Markers of Colorectal Anastomotic Leakage: A Systematic Review and Meta-Analysis |
| title_fullStr | Cytokines as Early Markers of Colorectal Anastomotic Leakage: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Cytokines as Early Markers of Colorectal Anastomotic Leakage: A Systematic Review and Meta-Analysis |
| title_short | Cytokines as Early Markers of Colorectal Anastomotic Leakage: A Systematic Review and Meta-Analysis |
| title_sort | cytokines as early markers of colorectal anastomotic leakage a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2016/3786418 |
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